Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life

2003 ◽  
Vol 54 (4) ◽  
pp. 514-520 ◽  
Author(s):  
Martin Klein ◽  
Nadine H. J. Engelberts ◽  
Henk M. van der Ploeg ◽  
Dorotheé G. A. Kasteleijn-Nolst Trenité ◽  
Neil K. Aaronson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
The Impact

Cognitive functions and quality of life in patients with low-grade gliomas: The impact of radiotherapy

1994 ◽  
Vol 36 (1) ◽  
pp. 48-54 ◽  
Author(s):  
M. J. B. Taphoorn ◽  
A. Klein Schiphorst ◽  
F. J. Snoek ◽  
J. Lindeboom ◽  
J. G. Wolbers ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Functions ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
The Impact

scholarly journals QOL-36. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii438-iii438
Author(s):  
Kathleen Dorris ◽  
Jessica Channell ◽  
Ashley Mettetal ◽  
Molly Hemenway ◽  
Natalie Briones ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Cell Activity ◽  
Cns Tumors ◽  
Low Grade ◽  
Tumor Type ◽  
Central Nervous System Tumor ◽  
The Impact

Abstract BACKGROUND Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), are a class of compounds found in marijuana. Numerous studies in adults have examined cannabinoid use in management of cancer-related symptoms such as nausea, anorexia, and pain. Less is known about the use in the pediatric oncology population. METHODS A prospective observational study has been ongoing since 2016 at Children’s Hospital Colorado to evaluate cannabinoids’ impact using PedsQL™ modules on quality of life of pediatric patients with central nervous system (CNS) tumors who are 2–18 years old. Laboratory assessments of T-cell activity and pharmacokinetics of CBD, THC and associated metabolites are in process. Diaries with exploratory information on cannabinoid use patterns are being collected. RESULTS Thirty-three patients (14:19; male:female) have been enrolled with a median age of 6.4 years (range, 2.9–17.7 years). The most common tumor type in enrolled patients is embryonal tumors (13/33; 39%). Nine (27%) patients have low-grade glial/glioneuronal tumors, and eight (24%) had high-grade/diffuse midline gliomas. The remaining patients had ependymoma or craniopharyngioma. The median time on cannabinoids is 9 months. Most (n=20) patients have used oral products with CBD and THC. One patient continues on cannabinoid therapy in follow up. Preliminary immune function analyses identified impaired neutrophil superoxide anion production and chemotaxis in patients taking cannabinoids at early time points on therapy. CONCLUSIONS Families of children with various CNS tumors are pursuing cannabinoid therapy for both antitumor and supportive care purposes. Analysis of the impact of cannabinoids on patients’ quality of life is ongoing.

Abstract WP445: Age Differences in the Impact of Sleep Apnea on Cognition and Quality of Life

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Kristin J Addison-Brown ◽  
Abraham J Letter ◽  
Henry K Yaggi ◽  
Leslie A McClure ◽  
Frederick W Unverzagt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Apnea ◽  
Cognitive Function ◽  
High Risk ◽  
Racial Differences ◽  
Short Form ◽  
Epidemiological Studies ◽  
Obstructive Sleep ◽  
The Impact

Introduction: Using a subsample from the national REasons for Geographic And Racial Differences in Stroke (REGARDS) study, we examined the associations of obstructive sleep apnea (OSA) with cognition and quality of life and whether these associations vary with age while controlling for other demographic factors and comorbid medical conditions. Methods: Stroke-free participants with complete data on OSA risk, cognition, and quality of life as of October 2010 were included (N =2,925; ages 47-93, 43% men, 35% black, 65% white). OSA risk was defined as high or low based on responses to the Berlin Sleep Questionnaire (BSQ). Cognitive function was assessed with three validated fluency and recall measures; quality of life was assessed with the 4-item Center for Epidemiological Studies-Depression (CESD-4) scale and the Medical Outcomes Study Short Form-12 (SF-12). MANCOVA statistics were applied to the cognitive and quality of life outcomes separately while accounting for potential confounders (age, sex, race, education, diabetes and dyslipidemia). Body mass index and hypertension were taken into account as part of the BSQ definition of OSA risk. Results: In fully adjusted models, those at high risk for OSA had significantly lower cognitive scores (p < .05) and lower quality of life (depressive symptoms and SF-12) (p < .0001) than those at low risk. Some of the associations were age-dependent, such that younger participants with high OSA risk had worse cognitive and quality of life scores than both younger participants with low OSA risk and older participants with high OSA risk. Discussion: Lower cognitive function and lower quality of life in those at high risk for sleep apnea remained after accounting for potentially confounding factors in a population-based sample. These relationships were more pronounced during middle age, with attenuated effects after age 70. It may be of particular importance to detect and treat OSA in younger adults.

Low-grade gliomas in adults

2011 ◽  
pp. 1-18 ◽  
Author(s):  
Nader Sanai ◽  
Susan Chang ◽  
Mitchel S. Berger
Keyword(s):  
Quality Of Life ◽  
Molecular Markers ◽  
Diagnostic Imaging ◽  
Recent Literature ◽  
Low Grade ◽  
Operative Techniques ◽  
Comprehensive Review ◽  
Low Grade Gliomas ◽  
Adjuvant Therapies

In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

scholarly journals Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51450 ◽  
Author(s):  
Asgeir S. Jakola ◽  
Geirmund Unsgård ◽  
Kristin S. Myrmel ◽  
Roar Kloster ◽  
Sverre H. Torp ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Surgical Strategy ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals Diagnostic assertiveness of cerebellar pilocytic astrocytoma in the pediatric age

2022 ◽  
Vol 10 (19) ◽  
pp. 41-47
Author(s):  
Ana L. Pichardo-Ávalos
Keyword(s):  
Quality Of Life ◽  
Pilocytic Astrocytoma ◽  
High Morbidity ◽  
Low Grade ◽  
Pediatric Age ◽  
Delay In Diagnosis ◽  
Tumor Lesion ◽  
The Cost ◽  
The Impact

Pilocytic astrocytoma of the cerebellum in the pediatric age is the most frequent benign tumor lesion of the nervous system in children according to the WHO. International literature mentions that being low-grade tumors they have a high curative capacity. If the entire tumor is resected, when it is completely removed, survival increases with a high quality of life for children who presented this pathology and was treated on time. However, the delay in diagnosis and therefore in its treatment could generate the possibility of tumor transformation, the malignant nature of the transformed injuries has a very high morbidity and mortality, without mentioning that the degree of cognitive sequelae greatly affects the quality of life of the survivors. That is why the training of pediatric and non-pediatric first contact doctors imply a great responsibility since it gives the population and patients suffering from this nosology the possibility to improve their future life, as well as reduce the cost of the impact caused by the injuries they suffer. On the other hand, these tumors can transform generating devastating prognoses, without taking into account the economic and social repercussions of patients suffering from a low-grade tumor. When it is detected and treated assertively in a timely manner, it offers them greater opportunities than those who did not have such a timely diagnosis.

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