Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds

2019 ◽  
Vol 20 (2) ◽  
pp. 1900278 ◽  
Author(s):  
Zhongyi Zhao ◽  
Changjiang Fan ◽  
Feng Chen ◽  
Yutai Sun ◽  
Yujun Xia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Er-Yuan Chuang ◽  
Chih-Wei Chiang ◽  
Pei-Chun Wong ◽  
Chih-Hwa Chen
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Damage ◽  
Medical Science ◽  
Cartilage Tissue Engineering ◽  
Polymeric Materials ◽  
Tissue Growth ◽  
Cartilage Tissue ◽  
Cellular Interaction ◽  
Polymeric Hydrogels

The treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. The chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. This paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. These gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. This article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering

2011 ◽  
Vol 7 (12) ◽  
pp. 4187-4194 ◽  
Author(s):  
Wei-Bor Tsai ◽  
Wen-Tung Chen ◽  
Hsiu-Wen Chien ◽  
Wei-Hsuan Kuo ◽  
Meng-Jiy Wang
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

scholarly journals Recent advances on gradient hydrogels in biomimetic cartilage tissue engineering

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2158 ◽  
Author(s):  
Ivana Gadjanski
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Blood Vessels ◽  
Cartilage Tissue Engineering ◽  
Structure And Function ◽  
Cartilage Tissue ◽  
Cartilaginous Tissue ◽  
Zonal Structure ◽  
Promising Target ◽  
And Function

Articular cartilage (AC) is a seemingly simple tissue that has only one type of constituting cell and no blood vessels and nerves. In the early days of tissue engineering, cartilage appeared to be an easy and promising target for reconstruction and this was especially motivating because of widespread AC pathologies such as osteoarthritis and frequent sports-induced injuries. However, AC has proven to be anything but simple. Recreating the varying properties of its zonal structure is a challenge that has not yet been fully answered. This caused the shift in tissue engineering strategies toward bioinspired or biomimetic approaches that attempt to mimic and simulate as much as possible the structure and function of the native tissues. Hydrogels, particularly gradient hydrogels, have shown great potential as components of the biomimetic engineering of the cartilaginous tissue.

TGF-β1 immobilized tri-co-polymer for articular cartilage tissue engineering

2006 ◽  
Vol 77B (2) ◽  
pp. 338-348 ◽  
Author(s):  
Cheng-Hung Chou ◽  
Winston T. K. Cheng ◽  
Chien-Cheng Lin ◽  
Chih-Hung Chang ◽  
Chien-Chen Tsai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Tgf Β1

Synergistic Action of Growth Factors and Dynamic Loading for Articular Cartilage Tissue Engineering

2003 ◽  
Vol 9 (4) ◽  
pp. 597-611 ◽  
Author(s):  
Robert L. Mauck ◽  
Steven B. Nicoll ◽  
Sara L. Seyhan ◽  
Gerard A. Ateshian ◽  
Clark T. Hung
Keyword(s):  
Tissue Engineering ◽  
Growth Factors ◽  
Articular Cartilage ◽  
Dynamic Loading ◽  
Cartilage Tissue Engineering ◽  
Synergistic Action ◽  
Cartilage Tissue

Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts

Biomaterials ◽  
2006 ◽  
Vol 27 (14) ◽  
pp. 2882-2889 ◽  
Author(s):  
Dirk Barnewitz ◽  
Michaela Endres ◽  
Ina Krüger ◽  
Anja Becker ◽  
Jürgen Zimmermann ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Articular Cartilage Defects
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