scholarly journals Recent advances on gradient hydrogels in biomimetic cartilage tissue engineering

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2158 ◽  
Author(s):  
Ivana Gadjanski
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Blood Vessels ◽  
Cartilage Tissue Engineering ◽  
Structure And Function ◽  
Cartilage Tissue ◽  
Cartilaginous Tissue ◽  
Zonal Structure ◽  
Promising Target ◽  
And Function

Articular cartilage (AC) is a seemingly simple tissue that has only one type of constituting cell and no blood vessels and nerves. In the early days of tissue engineering, cartilage appeared to be an easy and promising target for reconstruction and this was especially motivating because of widespread AC pathologies such as osteoarthritis and frequent sports-induced injuries. However, AC has proven to be anything but simple. Recreating the varying properties of its zonal structure is a challenge that has not yet been fully answered. This caused the shift in tissue engineering strategies toward bioinspired or biomimetic approaches that attempt to mimic and simulate as much as possible the structure and function of the native tissues. Hydrogels, particularly gradient hydrogels, have shown great potential as components of the biomimetic engineering of the cartilaginous tissue.

scholarly journals Recent advances on gradient hydrogels in biomimetic cartilage tissue engineering

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 2158 ◽  
Author(s):  
Ivana Gadjanski
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Blood Vessels ◽  
Cartilage Tissue Engineering ◽  
Structure And Function ◽  
Cartilage Tissue ◽  
Cartilaginous Tissue ◽  
Zonal Structure ◽  
Promising Target ◽  
And Function

Articular cartilage (AC) is a seemingly simple tissue that has only one type of constituting cell and no blood vessels and nerves. In the early days of tissue engineering, cartilage appeared to be an easy and promising target for reconstruction and this was especially motivating because of widespread AC pathologies such as osteoarthritis and frequent sports-induced injuries. However, AC has proven to be anything but simple. Recreating the varying properties of its zonal structure is a challenge that has not yet been fully answered. This caused the shift in tissue engineering strategies toward bioinspired or biomimetic approaches that attempt to mimic and simulate as much as possible the structure and function of the native tissues. Hydrogels, particularly gradient hydrogels, have shown great potential as components of the biomimetic engineering of the cartilaginous tissue.

scholarly journals Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Er-Yuan Chuang ◽  
Chih-Wei Chiang ◽  
Pei-Chun Wong ◽  
Chih-Hwa Chen
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Damage ◽  
Medical Science ◽  
Cartilage Tissue Engineering ◽  
Polymeric Materials ◽  
Tissue Growth ◽  
Cartilage Tissue ◽  
Cellular Interaction ◽  
Polymeric Hydrogels

The treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. The chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. This paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. These gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. This article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

scholarly journals An overview of advanced biocompatible and biomimetic materials for creation of replacement structures in the musculoskeletal systems: focusing on cartilage tissue engineering

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Azizeh Rahmani Del Bakhshayesh ◽  
Nahideh Asadi ◽  
Alireza Alihemmati ◽  
Hamid Tayefi Nasrabadi ◽  
Azadeh Montaseri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Interdisciplinary Approach ◽  
Culture Conditions ◽  
Vital Role ◽  
Cartilage Tissue ◽  
Biomimetic Materials ◽  
Musculoskeletal Tissue ◽  
And Function

Abstract Tissue engineering, as an interdisciplinary approach, is seeking to create tissues with optimal performance for clinical applications. Various factors, including cells, biomaterials, cell or tissue culture conditions and signaling molecules such as growth factors, play a vital role in the engineering of tissues. In vivo microenvironment of cells imposes complex and specific stimuli on the cells, and has a direct effect on cellular behavior, including proliferation, differentiation and extracellular matrix (ECM) assembly. Therefore, to create appropriate tissues, the conditions of the natural environment around the cells should be well imitated. Therefore, researchers are trying to develop biomimetic scaffolds that can produce appropriate cellular responses. To achieve this, we need to know enough about biomimetic materials. Scaffolds made of biomaterials in musculoskeletal tissue engineering should also be multifunctional in order to be able to function better in mechanical properties, cell signaling and cell adhesion. Multiple combinations of different biomaterials are used to improve above-mentioned properties of various biomaterials and to better imitate the natural features of musculoskeletal tissue in the culture medium. These improvements ultimately lead to the creation of replacement structures in the musculoskeletal system, which are closer to natural tissues in terms of appearance and function. The present review article is focused on biocompatible and biomimetic materials, which are used in musculoskeletal tissue engineering, in particular, cartilage tissue engineering.

Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering

2011 ◽  
Vol 7 (12) ◽  
pp. 4187-4194 ◽  
Author(s):  
Wei-Bor Tsai ◽  
Wen-Tung Chen ◽  
Hsiu-Wen Chien ◽  
Wei-Hsuan Kuo ◽  
Meng-Jiy Wang
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

Progress in Articular Cartilage Tissue Engineering: A Review on Therapeutic Cells and Macromolecular Scaffolds

2019 ◽  
Vol 20 (2) ◽  
pp. 1900278 ◽  
Author(s):  
Zhongyi Zhao ◽  
Changjiang Fan ◽  
Feng Chen ◽  
Yutai Sun ◽  
Yujun Xia ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue

TGF-β1 immobilized tri-co-polymer for articular cartilage tissue engineering

2006 ◽  
Vol 77B (2) ◽  
pp. 338-348 ◽  
Author(s):  
Cheng-Hung Chou ◽  
Winston T. K. Cheng ◽  
Chien-Cheng Lin ◽  
Chih-Hung Chang ◽  
Chien-Chen Tsai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Tgf Β1
Sign in / Sign up

Export Citation Format

Share Document