Theoretical approaches to drug design and biological activity: Critical comments to the use of mathematical methods applied to univariate and multivariate quantitative structure-activity relationships (QSAR)

Peter P. Mager

doi:10.1002/med.2610020106

Theoretical approaches to drug design and biological activity: Critical comments to the use of mathematical methods applied to univariate and multivariate quantitative structure-activity relationships (QSAR)

Medicinal Research Reviews ◽

10.1002/med.2610020106 ◽

1982 ◽

Vol 2 (1) ◽

pp. 93-121 ◽

Cited By ~ 15

Author(s):

Peter P. Mager

Keyword(s):

Biological Activity ◽

Drug Design ◽

Quantitative Structure ◽

Mathematical Methods ◽

Structure Activity Relationships ◽

Theoretical Approaches ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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ChemInform Abstract: Theoretical Approaches to Drug Design and Biological Activity: Critical Comments to the Use of Mathematical Methods Applied to Univariate and Multivariate Quantitative Structure-Activity Relationships (QSAR)

Chemischer Informationsdienst ◽

10.1002/chin.198418387 ◽

1984 ◽

Vol 15 (18) ◽

Author(s):

P. P. MAGER

Keyword(s):

Biological Activity ◽

Drug Design ◽

Quantitative Structure ◽

Mathematical Methods ◽

Structure Activity Relationships ◽

Theoretical Approaches ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(96)00174-6 ◽

1996 ◽

Vol 6 (10) ◽

pp. 1077-1082 ◽

Cited By ~ 6

Author(s):

C. Marot ◽

C. Comoy ◽

M.C. Viaud ◽

M.C. Rettori ◽

B. Pfeiffer ◽

...

Keyword(s):

Biological Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00128a035 ◽

1989 ◽

Vol 32 (8) ◽

pp. 1895-1905 ◽

Cited By ~ 25

Author(s):

Cynthia Dias Selassie ◽

Zhaoxia Fang ◽

Renli Li ◽

Corwin Hansch ◽

Gargi Debnath ◽

...

Keyword(s):

Drug Design ◽

Comparative Study ◽

Dihydrofolate Reductase ◽

Quantitative Structure ◽

Molecular Graphics ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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6 Quantitative drug design: parameters and quantitative structure activity relationships

SPARK ◽

10.1515/spark.77.7 ◽

2018 ◽

Author(s):

Joaquín M. Campos Rosa ◽

M. Encarnación Camacho Quesada

Keyword(s):

Drug Design ◽

Design Parameters ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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6. Quantitative drug design: parameters and quantitative structure activity relationships

Drug Design and Action ◽

10.1515/9783110528480-007 ◽

2017 ◽

pp. 90-106

Keyword(s):

Drug Design ◽

Design Parameters ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative structure-activity relationships (QSAR) with variable contribution of substituents to the biological activity of chemical compounds

Pharmaceutical Chemistry Journal ◽

10.1007/bf00777276 ◽

1982 ◽

Vol 16 (3) ◽

pp. 225-228

Author(s):

N. S. Antonov ◽

M. I. Gevenyan ◽

L. T. Tseirova

Keyword(s):

Biological Activity ◽

Chemical Compounds ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Variable Contribution ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships in Drug-Design

Drug Receptor Interactions in Antimicrobial Chemotherapy - Topics in Infectious Diseases ◽

10.1007/978-3-7091-8405-9_4 ◽

1975 ◽

pp. 45-56

Author(s):

Albert J. Leo

Keyword(s):

Drug Design ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships (QSAR)The definition also appears in the Glossary on Computational Drug Design.

IUPAC Standards Online ◽

10.1515/iupac.70.0145 ◽

2016 ◽

Author(s):

C. G. Wermuth ◽

C. R. Ganellin ◽

P. Lindberg ◽

L. A. Mitscher

Keyword(s):

Drug Design ◽

Quantitative Structure ◽

Computational Drug Design ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Development of Quantitative Structure-Activity Relationships and Its Application in Rational Drug Design

Current Pharmaceutical Design ◽

10.2174/138161206779010431 ◽

2006 ◽

Vol 12 (35) ◽

pp. 4601-4611 ◽

Cited By ~ 66

Author(s):

Guang-Fu Yang ◽

Xiaoqin Huang

Keyword(s):

Drug Design ◽

Rational Drug Design ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Rational Drug ◽

Quantitative Structure Activity Relationships

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Development of Quantitative Structure-Activity Relationships and Computer-Aided Drug Design

YAKUGAKU ZASSHI ◽

10.1248/yakushi1947.114.3_135 ◽

1994 ◽

Vol 114 (3) ◽

pp. 135-146 ◽

Cited By ~ 3

Author(s):

Ikuo MORIGUCHI

Keyword(s):

Drug Design ◽

Quantitative Structure ◽

Computer Aided Drug Design ◽

Structure Activity Relationships ◽

Structure Activity ◽

Computer Aided ◽

Quantitative Structure Activity Relationships

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