A Mini‐Review of Microstructural Control during Composite Fiber Spinning

2021 ◽  
Author(s):  
Weiheng Xu ◽  
Sayli Jambhulkar ◽  
Dharneedar Ravichandran ◽  
Yuxiang Zhu ◽  
Shantanu Lanke ◽  
...  
Keyword(s):  
Composite Fiber ◽  
Fiber Spinning ◽  
Microstructural Control

Delivery of Active FGF-2 From Mechanically-Stable Biological Nanofibers Accelerates Cell Ingress Into Multifiber Composites

2011 ◽  
Author(s):  
Jonathan A. Kluge ◽  
Rudra A. Pampati ◽  
Mara L. Schenker ◽  
Daniel J. Zhou ◽  
John E. Esterhai ◽  
...  
Keyword(s):  
Release Kinetics ◽  
Composite Fiber ◽  
Biochemical Properties ◽  
Fiber Spinning ◽  
Water Soluble ◽  
Silk Fibers ◽  
Synthetic Fibers ◽  
Nanofibrous Scaffolds ◽  
Biologic Factors

Fibrocartilaginous tissues such as the meniscus and annulus fibrosus serve critical load-bearing roles, relying on arrays of highly organized collagen fibers to resist tensile loads [1]. As these specialized structures are often injured, there exists great demand for engineered tissues for repair or replacement. Cell-laden aligned nanofibrous scaffolds formed from poly(ε-caprolactone) (PCL) have shown promise in achieving tissuelike mechanical and biochemical properties and can direct cellular and matrix organization in vitro [2]. A current limitation of nanofibrous scaffolds, however, is a slow rate of cellular infiltration, particularly in thick scaffolds. To address this, dynamic composite nanofibrous scaffolds have been fabricated via multi-fiber spinning [3], which can offer tunable modes of degradation depending on the polymer sources. For example, water-soluble polyethylene oxide (PEO) fibers can be co-spun with PCL to improve porosity and hasten cell ingress [4]. Incorporation of additional tunable and bioactive polymer sources may add greater versatility to these composite systems. For example, aqueous-based silk fibroin can be used as a slow-degrading, mechanically strong composite fiber component [5] into which active biologic factors (drugs, growth factors) can be incorporated [6]. Variably-degradable silk fibers can be formed by modulating post-spinning treatments, and protein release kinetics can likewise be manipulated by the physical crosslinking method [7]. We hypothesized that incorporation of robust and tunable silk protein-based fibers into a composite of slow-degrading synthetic fibers would provide mechanical function while delivering active biologic factors to expedite cell proliferation and encourage more rapid construct colonization. To test this hypothesis, we characterized the release kinetics of recombinant FGF-2 from silk fibers and its bioactivity in vitro and in a rat subcutaneous implant model.

Microstructural control of pitch matrix carbon-carbon composite by iodine treatment

1998 ◽  
Vol 13 (2) ◽  
pp. 302-307 ◽  
Author(s):  
H. Kajiura ◽  
Y. Tanabe ◽  
E. Yasuda ◽  
A. Kaiho ◽  
I. Shiota ◽  
...  
Keyword(s):  
Coal Tar ◽  
Carbon Composite ◽  
Coal Tar Pitch ◽  
Microstructural Development ◽  
Carbon Yield ◽  
Graphitic Structure ◽  
Matrix Microstructure ◽  
Iodine Treatment ◽  
Matrix Precursor ◽  
Microstructural Control

Matrix microstructure of a pitch-based carbon-carbon composite was controlled by an iodine treatment. Coal-tar pitch having the softening point of 101 °C was used as a matrix precursor. The iodine treatment was carried out on a pitch-impregnated specimen at 90 °C for 3–20 h. The specimen was carbonized at 800 °C and graphitized at 2000–3000 °C. The carbon yield increased from 73% to 93% by the iodine treatment. Microstructures of carbonized specimens changed from a flow type texture to a mosaic type one by the iodine treatment. The microstructural development to graphitic structure was suppressed by the iodine treatment.

scholarly journals Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 248
Author(s):  
Marta O. Teixeira ◽  
Joana C. Antunes ◽  
Helena P. Felgueiras
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Mechanical Stability ◽  
Fiber Spinning ◽  
Comprehensive Overview ◽  
Triggered Drug Release ◽  
Medicinal Properties ◽  
Hydrogel Composites ◽  
Drug Incorporation ◽  
Stimuli Sensitive

In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

Graphene/chitosan/Ag+- doped hydroxyapatite triple composite fiber coatings on new generation hybrid titanium composite by electrospinning

2021 ◽  
pp. 002199832110075
Author(s):  
Tuğba Mutuk ◽  
Mevlüt Gürbüz
Keyword(s):  
Hybrid Composites ◽  
Graphene Nanosheets ◽  
Pure Titanium ◽  
Composite Fiber ◽  
Mass Change ◽  
Coated Materials ◽  
Nano Fiber ◽  
Hybrid Nanofiber ◽  
New Generation ◽  
Fiber Coatings

In this work, The hybrid hydroxyapatite (HaP), chitosan (CH) and graphene nanosheets (GNS) mixtures were applied by electrospinning on the surface of GNS and Si3N4 (SN) binary powder reinforced hybrid titanium (Ti) metal composites surface to improve composite biosurface functionallity. The surfaces of coated materials were characterized and antibacterial tests were carried on for their suitability in the industry by performing artificial body fluid tests. The hybrid nano fiber coatings formed a homogeneous structure on the composite. According to bioactivity tests and microstructure analysis, it was seen that HaP, which has the best results in the change of pH (pH= 11.80) values. The lowest mass change (0.0005 g) was observed on the 10th day of pure titanium. The highest mass change (0.0210 g) was obtained as on the HaP coated hybrid titanium composite. According to the antibacterial test result the hybrid nanofiber containing silver (Ag+) doped HaP on Ti composites showed the best antibacterial property aganist the E.coli. The fabricated electrospin coated hybrid composites can be a potantial candidate for dental, orthopedic implant applications and tissue engineering.

Degradable ultrathin high-performance photocatalytic hydrogen generator from porous electrospun composite fiber membrane with enhanced light absorption ability

2021 ◽  
Author(s):  
Qian-Yu Wang ◽  
Zheng-Min Zhang ◽  
Lin Liu ◽  
Lu Bai ◽  
Rui-Ying Bao ◽  
...  
Keyword(s):  
Phase Separation ◽  
Light Absorption ◽  
High Performance ◽  
Composite Fiber ◽  
Channel Structure ◽  
Separation Mechanism ◽  
Hydrogen Generator ◽  
Fiber Membrane ◽  
Breath Figure ◽  
Phase Separation Mechanism

Poly(L-lactide) (PLA)/TiO2/Pt composite fiber membrane with internal porous channel structure is fabricated by skillfully tuning the breath figure mechanism and vapor induced phase separation mechanism with solute and solvent matching...

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