Body & brain: Lack of insulin damages kidnesys: High blood sugar is not only cause for concern in diabetics

Science News ◽  
2010 ◽  
Vol 178 (10) ◽  
pp. 11-11
Author(s):  
Nathan Seppa
Keyword(s):  
Blood Sugar ◽  
High Blood Sugar

scholarly journals THE HYPOPHYSIS AND SECRETION OF INSULIN

1942 ◽  
Vol 75 (5) ◽  
pp. 547-566 ◽  
Author(s):  
B. A. Houssay ◽  
V. G. Foglia ◽  
F. S. Smyth ◽  
C. T. Rietti ◽  
A. B. Houssay
Keyword(s):  
Insulin Secretion ◽  
B Cells ◽  
Blood Sugar ◽  
Anterior Pituitary ◽  
Blood Sugar Level ◽  
Pituitary Hormone ◽  
Pituitary Extract ◽  
Histological Changes ◽  
High Blood Sugar ◽  
Anterior Pituitary Hormone

The ability of the pancreas, from various types of dogs, to correct diabetic hyperglycemia has been studied (Table XI). The pancreas from one animal was united by a vascular union with the neck blood vessels of another dog which had been pancreatectomized for 20 hours. The time necessary to reduce the blood sugar level to 120 mg. per cent was determined. 1. Pancreas from 6 hypophysectomized dogs produced a normal insulin secretion, showing that an anterior pituitary hormone is not necessary for its production or maintenance. 2. In 14 of 17 normal dogs given anterior pituitary extract for 3 or more consecutive days and presenting diabetes (fasting blood sugar 150 mg. per cent or more) the pancreas showed diminished insulin production. 3. In animals which remained diabetic after discontinuing the injections of hypophyseal extract, the pancreas islands were markedly pathologic and the insulin secretion was practically nil. 4. When hyperglycemia existed on the 2nd to 5th day but fell later, the insulin secretion of 5 dogs was normal in 2, supernormal in 1, and less than normal in 2. Histologic examination showed a restoration of beta cells. 5. In 14 dogs resistant to the diabetogenic action of anterior pituitary extract, as shown by little or no change in blood sugar, the pancreatic secretion of insulin was normal in 6 cases, supernormal in 3, and subnormal in 5 cases. Clear signs of hyperfunction of B cells were observed. In 6 resistant animals a high blood sugar (150 mg. per cent) appeared shortly before transplanting, but insulin secretion was normal in 4, supernormal in 1, and subnormal in 1 case. 6. With one injection of extract and 1 day of hyperglycemia the capacity of the pancreas to secrete insulin was not altered. 7. A high blood sugar level lasting 4 days does not alter the islets. The hypophyseal extract acts, therefore, by some other mechanism. In normal dogs, the continuous intravenous infusion of glucose for 4 days maintained the blood sugar at levels as high as those after pituitary extract. In these animals the B cells were hyperplastic and insulin secretion normal. 8. Anterior hypophyseal hyperglycemia is due at first to extrapancreatic factors which are the most important, and last only during the injections of extracts. Pancreatic factors appear afterwards and are responsible for permanent diabetes. Hypophyseal extract produces histological changes in many tissues and damages the Langerhans islands. The coexistent high blood sugar probably exhausts the B cells and exaggerates their injury. 9. In all cases there is a relation between the cytology of the islet B cells and the insulin secreting capacity.

scholarly journals A MODERN OVERVIEW ON DIABETES MELLITUS: A CHRONIC ENDOCRINE DISORDER

2020 ◽  
Vol 5 (2) ◽  
pp. 1-14
Author(s):  
Y Mukhtar ◽  
A Galalain ◽  
U Yunusa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Hypoglycemic Agents ◽  
Dependent Diabetes Mellitus ◽  
High Blood Sugar ◽  
Type 2 Dm ◽  
Insulin Dependent

Diabetes mellitus is one of the most common endocrine disorders that affect the body’s ability to make or use insulin. Diabetes mellitus (DM), or simply diabetes, is a group of chronic metabolic diseases in which a person experience high blood sugar, either because the pancreas does not produce enough insulin or because the body cells do not effectively use or respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Conventionally, diabetes has been divided into three types namely: Type 1 DM or insulin-dependent diabetes mellitus (IDDM) in which body fails to produce insulin, and presently requires the person to inject insulin or wear an insulin pump. This is also termed as "juvenile diabetes". Type 2 DM or non-insulin-dependent diabetes mellitus (NIDDM), results from insulin resistance, a condition in which cells fail to use insulin properly, with or without an absolute insulin deficiency. This type was previously referred to as or "adult-onset diabetes". The third main type is gestational diabetes which occurs when women without a previous history of diabetes develop a high blood glucose level during her pregnancy and may metamorphose to type 2 DM after giving birth. Currently available pharmacotherapy for the treatment of diabetes mellitus includes insulin and oral hypoglycemic agents. Thus, the present review underscores the issues surrounding the symptoms, diagnosis and treatment (especially use of anti-diabetic herbal species) of this killer disease with a view to suppressing its global spread and resurgence.

scholarly journals Fasdhu therapy to reduce excess levels of substances in the human body

2021 ◽  
Vol 6 (7) ◽  
pp. 1276-1281
Author(s):  
Darmadi Darmadi ◽  
Siti Juariah ◽  
Sukri Sukri
Keyword(s):  
Uric Acid ◽  
Health Education ◽  
Blood Sugar ◽  
Body Fat ◽  
Human Body ◽  
High Blood Sugar ◽  
The People ◽  
Sugar Levels ◽  
Provide Health Education

Tarai Bangun Hamlet IV, Tarab Mulya Village is a village located in Kampar Regency where the majority of the people come from the Minang and Javanese tribes. They like to eat fatty foods that trigger an increase in body fat levels. This service is carried out with the aim of helping people who experience high blood sugar, cholesterol and uric acid levels with the phlebotomy technique (fasdhu). The method used is to provide health education, followed by checking blood sugar, cholesterol and uric acid. High levels are then performed Fasdhu. Based on the examination of blood sugar, cholesterol and uric acid checks on 37 respondents, it was found that 10 respondents had high levels. Fasdhu treatment was carried out on respondents who had blood sugar levels of 163 mg/dl, cholesterol 240.75 mg/dl and uric acid 8.95 mg/dl. After fasdhu treatment, the levels decreased to 107 mg/dl, 200 mg/dl and 7.15 mg/dl, respectively. Based on this treatment, it was concluded that the phlebotomy technique (fasdhu) could be recommended as an effort to reduce blood sugar, cholesterol and uric acid levels.

Stressful life events, hypertensive disorders, and high blood sugar during pregnancy

2020 ◽  
Vol 36 (2) ◽  
pp. 160-165
Author(s):  
Liwei Chen ◽  
Lu Shi ◽  
Margaret Shin Chao ◽  
Xia Tong ◽  
Fan Wang
Keyword(s):  
Blood Sugar ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
High Blood Sugar ◽  
Hypertensive Disorders

High Blood Sugar Levels in Rhesus Monkeys

1967 ◽  
Vol 46 (5) ◽  
pp. 1105-1105 ◽  
Author(s):  
Harold P. Rose ◽  
James S. Glenn ◽  
Andrew Kuna
Keyword(s):  
Blood Sugar ◽  
Rhesus Monkeys ◽  
High Blood Sugar ◽  
Sugar Levels

scholarly journals A Successful Treatment for Toxic Symptoms Resulting from Ether Anæsthesia, Based on a Biochemical Investigation

1933 ◽  
Vol 26 (4) ◽  
pp. 347-355 ◽  
Author(s):  
R. J. Minnitt
Keyword(s):  
Blood Pressure ◽  
Blood Sugar ◽  
Successful Treatment ◽  
Insulin Administration ◽  
High Blood Sugar ◽  
Biochemical Investigation ◽  
Successful Method ◽  
Ether Anaesthesia ◽  
Pancreatic Hormone

(1) Blood-sugar rises and blood-pressure falls as ether anæsthesia progresses.—(2) Blood-sugar is high and blood-pressure low when symptoms of shock are present.—(3) There is some justification for thinking that the pancreatic hormone is deficient as the result of the ketosis produced in connection with ether anæsthesia.—(4) Insulin administration is a successful method of treatment for post-anæsthetic toxic symptoms, which are always associated with a high blood-sugar, and also prevents these from developing. It tends to increase a fallen blood-pressure and reduce a raised blood-sugar during ether anæsthesia.

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