Autologous Neosphincters and Novel Technologies for Fecal continence

Author(s):  
Ali A. Shafik
2019 ◽  
Vol 141 (9) ◽  
Author(s):  
D. Liao ◽  
S. C. Chen ◽  
K. M. Lo ◽  
J. Zhao ◽  
K. Futaba ◽  
...  

A mechanical approach is needed for understanding anorectal function and defecation. Fecal continence is achieved by several interacting mechanisms including anatomical factors, anorectal sensation, rectal compliance, stool consistency, anal muscle strength, motility, and psychological factors. The balance is easily disturbed, resulting in symptoms such as fecal incontinence and constipation. Novel technologies have been developed in recent years for studying anorectal function. Especially, the Fecobionics device, a simulated feces, has gained attention recently. This facilitates new analysis of anorectal mechanical function. In this study, a theoretical model is developed to analyze anorectal mechanophysiological data generated by the Fecobionics device. Theoretical approaches can enhance future interdisciplinary research for unraveling defecatory function, sensory-motor disorders, and symptoms. This is a step in the direction of personalized treatment for gastrointestinal disorders based on optimized subtyping of anorectal disorders.


Author(s):  
Felicity Amaya Schaeffer

I argue that we are entering an automated era of border control that I label a border-biosecurity industrial complex. Funded in great part by the Department of Homeland Security (DHS), scientific research and automated surveillance technologies promise the state innovative and supposedly unbiased solutions to the challenge of border control and security. This article spotlights a border surveillance technology called AVATAR (Automated Virtual Agent for Truth Assessment in Real-Time). Analyzing this technology, which was funded by the DHS and developed by faculty at the University of Arizona’s National Center for Border Security and Immigration (BORDERS), allows me to assess how the emphasis on novel technologies to detect terrorists unleashes the search for ubiquitous surveillance devices programmed to detect deviant behavioral and physiological movements. I offer a wider view of this technology-in-the-making by analyzing how university research in aerial defense, the psychology of deception, the life sciences, and computer engineering influences the development of surveillance devices and techniques. I explore how, during a posthuman era, automated technologies detect and racialize “suspect life” under the guise of scientific neutrality and supposedly free from human interference. Suspect life refers to the racial bias preprogrammed into algorithms that compute danger or risk into certain human movements and regions such as border zones. As these technologies turn the body into matter, they present biological life as a more scientifically verifiable truth than human verbal testimony, moving border control from the adjudication of law through the subjective interview to the automated body that speaks a truth more powerful than a complex story can tell.


2020 ◽  
Vol 35 (2) ◽  
pp. 101-121
Author(s):  
Chava Brownfield-Stein

Examining the activities of the Israel Defense Forces along the Gaza-Israel border, this article identifies a new phase in what the author calls ‘military-police fusion’. The analysis focuses on novel technologies—remote-controlled weapon stations and unmanned ground vehicles—and on the women soldiers who operate these systems. The central claim is that the blurring of boundaries between military and policing missions, combined with high-tech weaponry, has resulted in the development and implementation of new modes of violence that are currently undergoing a process of redefinition and feminization. The article addresses three key dimensions of the processes occurring in the hybrid operational environment along the Gaza-Israel border: the legal dimension, the technological dimension, and the gender dimension.


2018 ◽  
Vol 1 (75) ◽  
pp. 47-50
Author(s):  
Mikhail Arkhipov ◽  
◽  
Nikolay Priyatkin ◽  
Ludmila Gusakova ◽  
Yuri Tyukalov ◽  
...  

Author(s):  
Sajad Khan ◽  
Shahid Ali ◽  
Muhammad

Background:Lung cancers or (Bronchogenic-Carcinomas) are the disease in certain parts of the lungs in which irresistible multiplication of abnormal cells leads to the inception of a tumor. Lung cancers consisting of two substantial forms based on the microscopic appearance of tumor cells are: Non-Small-Cell-Lung-Cancer (NSCLC) (80 to 85%) and Small-Cell-Lung-Cancer (SCLC) (15 to 20%).Discussion:Lung cancers are existing luxuriantly across the globe and the most prominent cause of death in advanced countries (USA & UK). There are many causes of lung cancers in which the utmost imperative aspect is the cigarette smoking. During the early stage, there is no perspicuous sign/symptoms but later many symptoms emerge in the infected individual such as insomnia, headache, pain, loss of appetite, fatigue, coughing etc. Lung cancers can be diagnosed in many ways, such as history, physical examination, chest X-rays and biopsy. However, after the diagnosis and confirmation of lung carcinoma, various treatment approaches are existing for curing of cancer in different stages such as surgery, radiation therapy, chemotherapy, and immune therapy. Currently, novel techniques merged that revealed advancements in detection and curing of lung cancer in which mainly includes: microarray analysis, gene expression profiling.Conclusion:Consequently, the purpose of the current analysis is to specify and epitomize the novel literature pertaining to the development of cancerous cells in different parts of the lung, various preeminent approaches of prevention, efficient diagnostic procedure, and treatments along with novel technologies for inhibition of cancerous cell growth in advance stages.


2020 ◽  
Vol 16 ◽  
Author(s):  
Ramazan Akçan ◽  
Halit Canberk Aydogan ◽  
Mahmut Şerif Yıldırım ◽  
Burak Taştekin ◽  
Necdet Sağlam

Background/aim: Use of nanomaterials in the healthcare applications increases in parallel to technological developments. It is frequently utilized in diagnostic procedures, medications and in therapeutic implementations. Nanomaterials take place among key components of medical implants, which might be responsible for certain toxic effects on human health at nano-level. In this review, nanotoxicological effects, toxicity determination of nanobiomaterials used in human body and their effects on human health are discussed. Material and Method: A detailed review of related literature was performed and evaluated as per nanomaterials and medical implants. Results and Conclusion: The nanotoxic effects of the materials applied to human body and the determination of its toxicity are important. Determination of toxicity for each nanomaterial requires a detailed and multifactorial assessment considering the properties of these materials. There are limited studies in the literature regarding the toxic effects of nanomaterials used in medical implants. Although these implants are potentially biocompatible and biodegradable, it is highly important to discuss nanotoxicological characteristics of medical implant.


2021 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Dimitris Koryzis ◽  
Apostolos Dalas ◽  
Dimitris Spiliotopoulos ◽  
Fotios Fitsilis

Societies are entering the age of technological disruption, which also impacts governance institutions such as parliamentary organizations. Thus, parliaments need to adjust swiftly by incorporating innovative methods into their organizational culture and novel technologies into their working procedures. Inter-Parliamentary Union World e-Parliament Reports capture digital transformation trends towards open data production, standardized and knowledge-driven business processes, and the implementation of inclusive and participatory schemes. Nevertheless, there is still a limited consensus on how these trends will materialize into specific tools, products, and services, with added value for parliamentary and societal stakeholders. This article outlines the rapid evolution of the digital parliament from the user perspective. In doing so, it describes a transformational framework based on the evaluation of empirical data by an expert survey of parliamentarians and parliamentary administrators. Basic sets of tools and technologies that are perceived as vital for future parliamentary use by intra-parliamentary stakeholders, such as systems and processes for information and knowledge sharing, are analyzed. Moreover, boundary conditions for development and implementation of parliamentary technologies are set and highlighted. Concluding recommendations regarding the expected investments, interdisciplinary research, and cross-sector collaboration within the defined framework are presented.


2021 ◽  
Vol 47 (02) ◽  
pp. 120-128
Author(s):  
Christina Caruso ◽  
Wilbur A. Lam

AbstractHemostasis is a complex wound-healing process involving numerous mechanical and biochemical mechanisms and influenced by many factors including platelets, coagulation factors, and endothelial components. Slight alterations in these mechanisms can lead to either prothrombotic or bleeding consequences, and such hemostatic imbalances can lead to significant clinical consequences with resultant morbidity and mortality. An ideal hemostasis assay would not only address all the unique processes involved in clot formation and resolution but also take place under flow conditions to account for endothelial involvement. Global assays do exist; however, these assays are not flow based. Flow-based assays have been limited secondary to their large blood volume requirements and low throughput, limiting potential clinical applications. Microfluidic-based assays address the aforementioned limitations of both global and flow-based assays by utilizing standardized devices that require low blood volumes, offer reproducible analysis, and have functionality under a range of shear stresses and flow conditions. While still largely confined to the preclinical space, here we aim to discuss these novel technologies and potential clinical implications, particularly in comparison to the current, commercially available point-of-care assays.


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