Perovskia abrotanoides Karel. Lamiaceae

2020 ◽  
pp. 1-2
Author(s):  
Hassan Sher ◽  
Rainer W. Bussmann ◽  
Narel Y. Paniagua-Zambrana ◽  
Ikram Ur Rahman
Keyword(s):  
Perovskia Abrotanoides

Green and Simple Synthesis of Silver Nanoparticles by Aqueous Extract of Perovskia abrotanoides: Characterization, Optimization and Antimicrobial Activity

2020 ◽  
Vol 21 (11) ◽  
pp. 1129-1137 ◽  
Author(s):  
Somayeh Mirsadeghi ◽  
Masoumeh F. Koudehi ◽  
Hamid R. Rajabi ◽  
Seied M. Pourmortazavi
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Minimum Inhibitory Concentration ◽  
Plant Extract ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Extraction Temperature ◽  
Silver Particles ◽  
Silver Nps ◽  
Perovskia Abrotanoides

Background: Herein, we report the biosynthesis procedure to prepare silver nanoparticles as reduction and capping agents with the aqueous plant extract of Perovskia abrotanoides. Methods: The therapeutic application of silver nanoparticles entirely depends on the size and shape of the nanoparticles therefore, their control during the synthesis procedure is so important. The effects of synthesis factors, for example, silver ion concentration, the mass of plant extract, reaction time and extraction temperature, on the size of silver particles were considered and optimized. Several analytical methods were used for the characterization of silver NPs including FT-IR and UV–Vis spectrophotometer, XRD and SEM. Results: The results showed that the mean size of the silver particles was about 51 nm. Moreover, the antibacterial properties of biosynthesized silver NPs were investigated by the minimum inhibitory concentration, minimum bactericidal concentration, and Well-diffusion tests. The minimum inhibitory concentration/ minimum bactericidal concentration values of silver NPs and aqueous plant extract versus Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and Gram-negative bacteria (E. coli) were 3.03/0.00, 1.20/0.01, 3.06/0.00, 0.98/1.04, 1.00/0.05 and 1.30/0.03 (mg/mL), respectively. Conclusion: The antimicrobial activity study displayed that the synthesized silver nanoparticles by plant extract have better antimicrobial properties compared to aqueous plant extract of Perovskia abrotanoides.

Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analogues

2006 ◽  
Vol 14 (15) ◽  
pp. 5285-5291 ◽  
Author(s):  
Yutaka Aoyagi ◽  
Yoshinao Takahashi ◽  
Yudai Satake ◽  
Koichi Takeya ◽  
Ritsuo Aiyama ◽  
...  
Keyword(s):  
Abietane Diterpenoids ◽  
Perovskia Abrotanoides

Perovskia abrotanoides Kar.

2012 ◽  
pp. 459-459
Author(s):  
Shakhnoza S. Azimova ◽  
Anna I. Glushenkova
Keyword(s):  
Perovskia Abrotanoides

scholarly journals Chemical Analysis and Calcium Channel Blocking Activity of the Essential Oil of Perovskia abrotanoides

2013 ◽  
Vol 8 (11) ◽  
pp. 1934578X1300801 ◽  
Author(s):  
Abdul Jabbar Shah ◽  
Munawwer Rasheed ◽  
Qaiser Jabeen ◽  
Amir Ahmed ◽  
Rasool Bakhsh Tareen ◽  
...  
Keyword(s):  
Essential Oil ◽  
Calcium Channel ◽  
Response Curves ◽  
Spasmolytic Activity ◽  
Medicinal Use ◽  
Voltage Dependent ◽  
Rabbit Jejunum ◽  
Voltage Dependent Calcium Channels ◽  
Pre Treatment ◽  
Perovskia Abrotanoides

The aim of this study was to investigate the chemical composition and provide a pharmacological base for the medicinal use of the essential oil of Perovskia abrotanoides (Pa. Oil) in gastrointestinal disorders, such as colic. The chemical investigation resulted in the identification of 26 compounds, of which tricyclene, β- trans-ocimene, terpinene-4-acetate, terpinen-4-ol, caran-3β-ol, linalyl acetate, β-caryophyllene oxide and α-elemene had not previously been reported from P. abrotanoides. Major constituents were 1,8-cineol and δ–3-carene, which constituting 50% of the oil. In the isolated rabbit jejunum preparation Pa.Oil caused inhibition of spontaneous and high K+ (80 mM)-induced contractions, with respective EC50 values of 0.13 (0.08-0.20; n=4) and 0.90 mg/mL (0.50–1.60; n=5), thus showing that spasmolytic activity is mediated possibly through calcium channel blockade (CCB). The CCB activity was confirmed when pre-treatment of the tissue with Pa. Oil (0.03-0.1 mg/mL) caused a rightward shift in the Ca++ concentration-response curves, similar to that caused by verapamil, a standard calcium channel blocker. These data indicate that the essential oil of P. abrotanoides possesses spasmolytic activity mediated possibly through inhibition of voltage-dependent calcium channels, which may explain its medicinal use in colic and possibly diarrhea.

Effects of some elicitors on tanshinone production in adventitious root cultures of Perovskia abrotanoides Karel

2015 ◽  
Vol 67 ◽  
pp. 97-102 ◽  
Author(s):  
Arehzoo Zaker ◽  
Christina Sykora ◽  
Florian Gössnitzer ◽  
Parvaneh Abrishamchi ◽  
Javad Asili ◽  
...  
Keyword(s):  
Adventitious Root ◽  
Root Cultures ◽  
Adventitious Root Cultures ◽  
Perovskia Abrotanoides

scholarly journals A Study on the Effects of Perovskia abrotanoides Karel on Experimental Skin Burn in Male Rat: in-vivo and in-vitro Findings

2019 ◽  
Vol 27 (122) ◽  
pp. 17-22
Author(s):  
Amin Derakhshanfar ◽  
Seyedeh-Sara Hashemi ◽  
Javad Moayedi ◽  
Mahjoob Vahedi ◽  
Davood Mehrabani ◽  
...  
Keyword(s):  
Male Rat ◽  
Skin Burn ◽  
Perovskia Abrotanoides

Antiprotozoal Diterpenes from Perovskia abrotanoides

Planta Medica ◽  
2018 ◽  
Vol 84 (12/13) ◽  
pp. 913-919 ◽  
Author(s):  
Marzieh Tabefam ◽  
Mahdi Farimani ◽  
Ombeline Danton ◽  
Justine Ramseyer ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
High Performance ◽  
Leishmania Donovani ◽  
Ionization Mass ◽  
Trypanosoma Brucei Rhodesiense ◽  
Selective Toxicity ◽  
L6 Cells ◽  
Aerial Parts ◽  
New Compounds ◽  
Perovskia Abrotanoides ◽  
Ethyl Acetate Extracts

AbstractAs part of a screening for new antiparasitic natural products from Iranian plants, n-hexane and ethyl acetate extracts from the aerial parts of Perovskia abrotanoides were found to exhibit strong inhibitory activity against Trypanosoma brucei rhodesiense and Leishmania donovani. The activity was tracked by high-performance liquid chromatography (HPLC)-based activity profiling. Preparative isolation by a combination of silica gel column chromatography and HPLC afforded 17 diterpenoids (1–17), including 14 abietane-, two icetexane-, and one isopimarane-type derivatives. Among these, (5R,10S)-11-hydroxy-12-methoxy-20-norabieta-8,11,13-triene (2), 12-hydroxy-norabieta-1(10),8,11,13-tetraene-1,11-furan (6), and 12-methoxybarbatusol (9) were new compounds, the structure of which was established by comprehensive spectroscopic data analysis (one- and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, electronic circular dichroism). The antiprotozoal activity of the isolated compounds was evaluated against T. b. rhodesiense, Trypanosoma cruzi, L. donovani, and Plasmodium falciparum. Selectivity indexes (SI) were calculated in comparison to cytotoxicity on rat myoblast (L6) cells. Particularly active were 7α-ethoxyrosmanol (4) with an IC50 of 0.8 µM against T. b. rhodesiense (SI 14.9) and an IC50 of 1.8 µM (SI 6.9) against L. donovani, ferruginol (8) with an IC50 of 2.9 µM (SI 19.2) against P. falciparum, and miltiodiol (10) with an IC50 of 0.5 µM (SI 10.5) against T. b. rhodesiense. None of the compounds exhibited selective toxicity against T. cruzi (SI ≤ 1.6).

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