Thermal skin burn in a late gestation period in experimental animals: state of the system “mother-fetus”

Objective. To study the effect of thermal skin burns in experimental animals (rats) on the state of the system “mother-fetus” in a late gestation period.Materials and methods. An experimental study was carried out on 18 female outbred white rats weighing 300–350 g (per 9 rats in the control and experimental groups), which were exposed to third-degree thermal burns with an area of 12 cм2 in a late gestation period. The oxygen transport function and the main blood biochemical markers were studied. The effect of thermal injury on the course of pregnancy was studied.Results. The thermal skin burn in the rats in the late gestation period leads to the development of hypoxia, a decrease in the affinity of hemoglobin for oxygen and metabolic acidosis in the mother’s body. Changes in the blood biochemical markers indicate the presence of endogenous intoxication. In the experimental animal group, a decrease in fetal weight was observed, an increase in the post-implantation fetal death rate was noted.Conclusion. Impaired oxygen homeostasis and endogenous intoxication in skin burns in rats in late gestation periods lead to fetal malnutrition and a qualitative increase in the post-implantation fetal death rate.

Electrospun Fibers Loaded with Natural Bioactive Compounds as a Biomedical System for Skin Burn Treatment. A Review

Burns are a major threat to public health and the economy due to their costly and laborious treatment and high susceptibility to infection. Efforts have been made recently to investigate natural bioactive compounds with potential use in wound healing. The importance lies in the capacities that these compounds could possess both in infection control by common and resistant microorganisms, as well as in the regeneration of the affected tissues, having in both cases low adverse effects. However, some bioactive molecules are chemically unstable, poorly soluble, and susceptible to oxidative degradation or have low bioavailability. Therefore, developing new technologies for an efficient treatment of wound healing poses a real challenge. In this context, electrospun nanofibers have gained increasing research interest because bioactive molecules can be easily loaded within the nanofiber, resulting in optimal burst control and enhanced drug stability. Additionally, the nanofibers can mimic the extracellular collagen matrix, providing a suitable highly porous structural support for growing cells that facilitate and accelerate skin burns healing. This review gives an overview of the current state of electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment.

Design of chitosan-poloxamer nanogel and evaluation of its therapeutic effect on skin burn

Wound infection is the main cause of slow healing and complications of skin burns. Wound dressings can temporarily replace the skin to isolate the contamination and can be anti-infective, which is conducive to wound healing. In this study, a chitosan-Poloxamer-apigenin nanogel dressing (CTS-Plo-Api) was constructed using CTS and Plo, as carriers, and Api. In comparison with traditional treatments, the speed of wound healing is improved with the use of CTS-Plo-Api; moreover, it enhances bacteriostatic and anti-infection ability and has certain analgesic effects. Therefore, we demonstrate that CTS-Plo-Api is an exciting new clinical avenue for the treatment of burn patients.

Third-degree full-thickness burns as a complication of cervical radiofrequency ablation

A 46-year-old woman underwent a cervical radiofrequency ablation (RFA) for chronic neck pain. Following the procedure, two areas surrounding the grounding pad in the lumbar region developed full thickness third-degree burns. Burn injuries following cervical RFA are rarely reported and are most often associated with cardiac and solid tumour RFA. Only one other case has been reported in literature with a similar outcome following a thoracic facet RFA. In our case, the lesion was directly from the ground pad and not from the radiofrequency electrode, which is more often the culprit. This is the first case reported in the literature of a full-thickness skin burn from a cervical RFA. Physicians should be aware of the potential for severe burns around the RF probe and ground pad as sequelae of RFA, and we caution the use of sedation during the procedure, as patients will unlikely be able to report any unusual sensation.

Analisis Retouching Foto Close Up Karya Petra Sinuraya Menggunakan Teknik Digital

This study aims to describe the concept and process of visualization of the close-up photo retouching technique by Petra Sinuraya. This research method is descriptive analytic research on the work. The subject of this type of research is Petra Sinuraya's close up photography retouching work. Data were analyzed descriptively analytic with percentage analysis using simple statistical procedures. Data obtained by using interview and documentation methods. The instrument was designed based on interview and documentation guidelines, and was developed based on situations that occurred in the field. The research was conducted by taking and selecting documents in the form of 10 pieces of art photos. The results showed that the close-up photo retouching process used by Petra Sinuraya was a digital technique by sharpening skills through the touch of tools available in Photoshop software. The role of composition in the retouching process is very important for client needs so that the photo looks more attractive in the final result. As for what Petra Sinuraya does in Close Up photo retouching is in various ways such as the Spot Hiling Brush for Smoothing the Skin, Burn and dodge tool for eye retouching, Dodge and Burn for Lightening / Darkening Contrast, filter noise and Gaussian blur - for flawless skin. and the Patch tool to enhance photos.

SAR Performance of Rectangular Microstrip Antenna for Breast Cancer Hyperthermia Treatment with Different Period of Treatment Procedure

Cancer treatment using hyperthermia techniques recently become the interest among researchers in investigating and improving certain deficiencies of the treatment since this treatment has the potential to denaturate cancer into necrotic tissue. Hyperthermia uses high heat from 41°C to 45°C at a certain period of time. It is difficult to control the focus position distance of heat distribution on the treated tissue. Therefore, this paper presents the rectangular microstrip as hyperthermia applicator, which deliver the heat on the targeted treated breast cancer tissue with different period of time in order to obtain sufficient heat or SAR distribution. Sim4LifeLight software simulator is used to design, simulate and generate the specific absorption rate (SAR) distribution on the treated tissue. Three frequencies of 434MHz, 915MHz and 2450MHz are used to be compared. Based on the results, 2450MHz shows better performance than the other two frequencies. However, there is a certain limitation, such as skin burn and unwanted hotspots, that need to be further improved. The cancer is sufficiently heating at different operating frequencies at different periods of procedures.