scholarly journals Solute Driven Transient Convection in Layered Porous Media

2021 ◽  
pp. 3-9
Author(s):  
Emmanuel E. Luther ◽  
Seyed M. Shariatipour ◽  
Michael C. Dallaston ◽  
Ran Holtzman
Keyword(s):  
Convective Instability ◽  
Onset Time ◽  
Fluid Phase ◽  
Deep Saline Aquifer ◽  
Research Attention ◽  
Storage Security ◽  
Permeability Distribution ◽  
Layered Porous Media ◽  
Geological Formations

AbstractCO2 geological sequestration has been proposed as a climate change mitigation strategy that can contribute towards meeting the Paris Agreement. A key process on which successful injection of CO2 into deep saline aquifer relies on is the dissolution of CO2 in brine. CO2 dissolution improves storage security and reduces risk of leakage by (i) removing the CO2 from a highly mobile fluid phase and (ii) triggering gravity-induced convective instability which accelerates the downward migration of dissolved CO2. Our understanding of CO2 density-driven convection in geologic media is limited. Studies on transient convective instability are mostly in homogeneous systems or in systems with heterogeneity in the form of random permeability distribution or dispersed impermeable barriers. However, layering which exist naturally in sedimentary geological formations has not received much research attention on transient convection. Therefore, we investigate the role of layering on the onset time of convective instability and on the flow pattern beyond the onset time during CO2 storage. We find that while layering has no significant effect on the onset time, it has an impact on the CO2 flux. Our findings suggest that detailed reservoir characterisation is required to forecast the ability of a formation to sequester CO2.

scholarly journals The role of exosomes in lung cancer metastasis and clinical applications: an updated review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lei Yin ◽  
Xiaotian Liu ◽  
Xuejun Shao ◽  
Tao Feng ◽  
Jun Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Cancer Cell ◽  
Cancer Metastasis ◽  
Value Assessment ◽  
Lung Carcinogenesis ◽  
Research Attention ◽  
Mesenchymal Transition ◽  
Lung Cancer Metastasis

AbstractLung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities. In recent years, exosomes have received increasing research attention in their role in the induction of carcinogenesis and metastasis in the lung. In this review, recent studies on the contribution of exosomes to lung cancer metastasis are discussed, particularly highlighting the role of lung tumor-derived exosomes in immune system evasion, epithelial-mesenchymal transition, and angiogenesis, and their involvement at both the pre-metastatic and metastatic phases. The clinical application of exosomes as therapeutic drug carriers, their role in antitumor drug resistance, and their utility as predictive biomarkers in diagnosis and prognosis are also presented. The metastatic activity, a complex multistep process of cancer cell invasion, survival in blood vessels, attachment and subsequent colonization of the host's organs, is integrated with exosomal effects. Exosomes act as functional mediating factors in cell–cell communication, influencing various steps of the metastatic cascade. To this end, lung cancer cell-derived exosomes enhance cell proliferation, angiogenesis, and metastasis, regulate drug resistance, and antitumor immune activities during lung carcinogenesis, and are currently being explored as an important component in liquid biopsy assessment for diagnosing lung cancer. These nano-sized extracellular vesicles are also being explored as delivery vehicles for therapeutic molecules owing to their unique properties of biocompatibility, circulatory stability, decreased toxicity, and tumor specificity. The current knowledge of the role of exosomes highlights an array of exosome-dependent pathways and cargoes that are ripe for exploiting therapeutic targets to treat lung cancer metastasis, and for predictive value assessment in diagnosis, prognosis, and anti-tumor drug resistance.

scholarly journals Pediatric Antiphospholipid Syndrome: from Pathogenesis to Clinical Management

2021 ◽  
Vol 23 (2) ◽  
Author(s):  
Silvia Rosina ◽  
Cecilia Beatrice Chighizola ◽  
Angelo Ravelli ◽  
Rolando Cimaz
Keyword(s):  
Antiphospholipid Syndrome ◽  
Fluid Phase ◽  
Multiple Organ ◽  
Clinical Settings ◽  
Glycoprotein I ◽  
Long Term Follow Up ◽  
Pediatric Populations ◽  
Cellular Components

Abstract Purpose of Review Elucidating the pathogenic mechanisms mediated by antiphospholipid antibodies (aPL) might exert important clinical implications in pediatric antiphospholipid syndrome (APS). Recent Findings aPL are traditionally regarded as the main pathogenic players in APS, inducing thrombosis via the interaction with fluid-phase and cellular components of coagulation. Recent APS research has focused on the role of β2 glycoprotein I, which bridges innate immunity and coagulation. In pediatric populations, aPL should be screened in appropriate clinical settings, such as thrombosis, multiple-organ dysfunction, or concomitant systemic autoimmune diseases. Children positive for aPL tests often present non-thrombotic non-criteria manifestations or asymptomatic aPL positivity. In utero aPL exposure has been suggested to result in developmental disabilities, warranting long-term follow-up. Summary The knowledge of the multifaceted nature of pediatric APS should be implemented to reduce the risk of underdiagnosing/undertreating this condition. Hopefully, recent pathogenic insights will open new windows of opportunity in the management of pediatric APS.

Acquisition versus greenfield in Colombia: Reviewing the effect of cultural distance and vicarious experience

2022 ◽  
pp. 147059582110644
Author(s):  
Mario Martínez-Avella ◽  
Ángela Alarcón-León ◽  
Giovanni Hernández-Salazar
Keyword(s):  
Cultural Distance ◽  
Cultural Dimensions ◽  
Vicarious Experience ◽  
Entry Modes ◽  
Direct Experience ◽  
Research Attention ◽  
Foreign Companies ◽  
Foreign Countries ◽  
The Individual

The relation between the cultural distance and the firm’s entry modes to foreign countries has received considerable research attention, and studies have shown the role of experience in this relation. However, previous research has only studied direct experience and neglected the study of vicarious experience. Using a sample of 355 foreign companies that entered Colombia (2007–2017), this research reviews the effect of cultural distance on entry mode choice (e.g., Acquisition vs. Greenfield) and examines the moderating role of vicarious experience in this relationship. The study concludes that the cultural distance positively affects the entry probability by acquisition, and the vicarious experience negatively affects this relationship in four cultural dimensions. If firms have vicarious experience, the effect of cultural distance on the acquisition probability is less and positively influences the entry probability by Greenfield when the cultural distance is in power distance, uncertainty avoidance, individualism, and long-term orientation. Nevertheless, vicarious experience has the opposite effect when considering the masculinity dimension. Consequently, we highlight the importance of considering vicarious experience as a different variable of direct experience and the individual effects of cultural distance dimensions for cross-cultural studies in management.

Multiple jobholders and workplace learning

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Anu Järvensivu
Keyword(s):  
Workplace Learning ◽  
Core Competencies ◽  
Core Competency ◽  
Meaningful Work ◽  
University Graduates ◽  
Snowball Sampling ◽  
Research Attention ◽  
Content Type ◽  
Practical Implications

Purpose The purpose of this research is to explore the career development and workplace learning of Finnish multiple jobholders who are university graduates. Design/methodology/approach 45 in-depth interviews were conducted with graduate multiple jobholders in Finland. The transcripts were analyzed by abductive content analysis using the Chaos Theory of Careers. Research participants were recruited via social media, invitations, snowball sampling and through networks. Findings Meaningful work was the attractor, the central factor in the decision to be a multiple jobholder. Interviewees attempted to adjust to future changes through their learning and choice of jobs and reported on their role as creators of future working life. Interviewees regarded organizing of their work and timetable as a core competency with their identity closely linked to their competencies and networks. Research limitations/implications The author acknowledges that the national context of Finland is unusually favorable to those becoming multiple job holders. Practical implications The identification of meaningful work as the key attractor, the intention to adapt to future contexts and the specifying of organization of work and timetabling as core competencies in multiple jobholding have clear practical implications at the national, local, organizational and individual levels. Originality/value Little has previously been known of the role of multiple jobholding as a facilitator in skill development and limited knowledge of how the various jobs combine into one portfolio. Previous studies have focused on individuals who take a second job to earn more money. Elite multiple jobholding has attracted little research attention yet seems to have an important role in achieving changes in society.

Synaptojanin family members are implicated in endocytic membrane traffic in yeast

1998 ◽  
Vol 111 (22) ◽  
pp. 3347-3356 ◽  
Author(s):  
B. Singer-Kruger ◽  
Y. Nemoto ◽  
L. Daniell ◽  
S. Ferro-Novick ◽  
P. De Camilli
Keyword(s):  
Synaptic Vesicles ◽  
Direct Evidence ◽  
Family Members ◽  
Fluid Phase ◽  
Growth Defect ◽  
Temperature Sensitive ◽  
Close Link ◽  
Fluid Phase Endocytosis ◽  
Synaptojanin 1

The synaptojanins represent a subfamily of inositol 5′-phosphatases that contain an NH2-terminal Sac1p homology domain. A nerve terminal-enriched synaptojanin, synaptojanin 1, was previously proposed to participate in the endocytosis of synaptic vesicles and actin function. The genome of Saccharomyces cerevisiae contains three synaptojanin-like genes (SJL1, SJL2 and SJL3), none of which is essential for growth. We report here that a yeast mutant lacking SJL1 and SJL2 (Deltasjl1 Deltasjl2) exhibits a severe defect in receptor-mediated and fluid-phase endocytosis. A less severe endocytic defect is present in a Deltasjl2 Deltasjl3 mutant, while endocytosis is normal in a Deltasjl1 Deltasjl3 mutant. None of the mutants are impaired in invertase secretion. The severity of the endocytic impairment of the sjl double mutants correlates with the severity of actin and polarity defects. Furthermore, the deletion of SJL1 suppresses the temperature-sensitive growth defect of sac6, a mutant in yeast fimbrin, supporting a role for synaptojanin family members in actin function. These findings provide a first direct evidence for a role of synaptojanin family members in endocytosis and provide further evidence for a close link between endocytosis and actin function.

Involvement of Subcortical Structures in the Preparation of Self-Paced Movement

2004 ◽  
Vol 18 (2/3) ◽  
pp. 130-139 ◽  
Author(s):  
Guillermo Paradiso ◽  
Danny Cunic ◽  
Robert Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Onset Time ◽  
Movement Planning ◽  
Movement Preparation ◽  
Subcortical Structures ◽  
Postoperative Mri ◽  
Deep Brain

Abstract Although it has long been suggested that the basal ganglia and thalamus are involved in movement planning and preparation, there was little direct evidence in humans to support this hypothesis. Deep brain stimulation (DBS) is a well-established treatment for movement disorders such as Parkinson's disease, tremor, and dystonia. In patients undergoing DBS surgery, we recorded simultaneously from scalp contacts and from electrodes surgically implanted in the subthalamic nucleus (STN) of 13 patients with Parkinson's disease and in the “cerebellar” thalamus of 5 patients with tremor. The aim of our studies was to assess the role of the cortico-basal ganglia-thalamocortical loop through the STN and the cerebello-thalamocortical circuit through the “cerebellar” thalamus in movement preparation. The patients were asked to perform self-paced wrist extension movements. All subjects showed a cortical readiness potential (RP) with onset ranging between 1.5 to 2s before the onset of movement. Subcortical RPs were recorded in 11 of 13 with electrodes in the STN and in 4 of 5 patients with electrodes in the thalamus. The onset time of the STN and thalamic RPs were not significantly different from the onset time of the scalp RP. The STN and thalamic RPs were present before both contralateral and ipsilateral hand movements. Postoperative MRI studies showed that contacts with maximum RP amplitude generally were inside the target nucleus. These findings indicate that both the basal ganglia and the cerebellar circuits participate in movement preparation in parallel with the cortex.

scholarly journals Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection

2018 ◽  
Vol 14 (12) ◽  
pp. e1007469 ◽  
Author(s):  
Valeria Ciancarella ◽  
Luigi Lembo-Fazio ◽  
Ida Paciello ◽  
Anna-Karin Bruno ◽  
Sébastien Jaillon ◽  
...  
Keyword(s):  
Fluid Phase ◽  
Intracellular Pathogen

Substance Use Disorders and Intentional Injury

2014 ◽  
Author(s):  
S. Janet Kuramoto-Crawford ◽  
Holly C. Wilcox
Keyword(s):  
Substance Use ◽  
Alcohol Use ◽  
Substance Use Disorders ◽  
Partner Violence ◽  
Alcohol Use Disorders ◽  
Research Attention ◽  
Intentional Injuries ◽  
Drug Use Disorders ◽  
The Relationship

Intentional injuries affect millions of lives worldwide. The authors provide an overview of the epidemiological and preventive evidence on the relationship between substance use disorders (SUD) and intentional injuries. Emphasis is placed on suicide and intimate partner violence, as each area has received substantial research attention in relation to SUD. There is robust epidemiological evidence on the relationship between SUD, notably with alcohol use disorders, and most intentional injuries. Research has focused on the identification of factors that distinguish individuals with alcohol use disorders who are at particularly high risk for intentional injuries. Characterization of those with other drug use disorders who are at risk for engaging in intentional injuries and the role of SUD in intentional injuries has been less extensively investigated. The authors conclude with a discussion of public health approaches to the prevention of intentional injuries among individuals with SUD.

scholarly journals Big-eged bugs Geocoris: Diets research and potential of use in prevention of a number of insect pests in Vietnam

2020 ◽  
Vol 9 (1) ◽  
pp. 70-77
Author(s):  
Nguyen Ngoc Bao Chau ◽  
Le Thuy To Nhu
Keyword(s):  
Sustainable Agriculture ◽  
Host Plant ◽  
Insect Pests ◽  
Short Review ◽  
Mass Rearing ◽  
Research Attention ◽  
Perennial Crops ◽  
The World ◽  
Agriculture Development

Big-eyed bugs Geocoris spp. (Lygaeidae, Hemiptera) are small insects that is found in many parts of the world. They are beneficial because they eat a multitude of insect pests in agriculture. Big-eyed bugs Geocoris spp. are insects that receive research attention in Florida and elsewhere because of the benefits that this species give to plants (Mead, 2001). Big-eyed bugs reproduce many generations in a year on weeds, perennial crops, bushes. In spring the female big-eyed bugs start laying eggs on the bud, the leaves of the host plant. Understanding the biology and the role of predator Geocoris spp. in ecosystem will provide an alternative method in sustainable agriculture development. In this short review, we discuss some convenient diets for the application of mass rearing Geocoris spp.

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