Bioinert Ceramics: Zirconia and Alumina

2016 ◽  
pp. 59-89 ◽  
Author(s):  
Corrado Piconi ◽  
Alessandro Alan Porporati
Keyword(s):  
Bioinert Ceramics

Re-evaluation of the biocompatibility of bioinert ceramics in vivo

Biomaterials ◽  
1992 ◽  
Vol 13 (4) ◽  
pp. 195-200 ◽  
Author(s):  
K HAYASHI ◽  
N MATSUGUCHI ◽  
K UENOYAMA ◽  
Y SUGIOKA
Keyword(s):  
Bioinert Ceramics

scholarly journals Bone-implant Interface Mechanics of in vivo Bioinert Ceramics.

1994 ◽  
Vol 43 (2) ◽  
pp. 724-727
Author(s):  
Tatsuro Inadome ◽  
Kazuo Hayashi ◽  
Tatsuoki Mashima ◽  
Yoichi Sugioka
Keyword(s):  
Bone Implant ◽  
Interface Mechanics ◽  
Bioinert Ceramics

Bioinert Ceramics: State-of-the-Art

2017 ◽  
Vol 758 ◽  
pp. 3-13 ◽  
Author(s):  
Corrado Piconi
Keyword(s):  
Heart Valves ◽  
State Of The Art ◽  
High Reliability ◽  
Pyrolytic Carbon ◽  
Metal Free ◽  
Number Of Patients ◽  
Artificial Heart Valves ◽  
Ceramic Components ◽  
Cad Cam ◽  
Bioinert Ceramics

Bioinert ceramics in use today are the result of more than 60 years of continuous development. Early studies were concentrated on alumina that in the late 1960s was the most advanced ceramic, and on pyrolytic carbon. After tests in orthopedic bearings, pyrolytic carbon found clinical applications in artificial heart valves, where it is in clinical use so far. After 1970 zirconia-toughened ceramics (YTZP, ZTA, ATZ) were investigated in view of their use as biomaterials in orthopedics. Especially the introduction of YTZP in clinics in the 1990s gave a new momentum to the use of inert bioceramics. So far, zirconia-toughened ceramics are replacing alumina because of their outstanding mechanical properties leading to high reliability in ceramic components. The behavior of ZTAs and ATZs are exploited in several innovative devices. Especially metal-free devices are of interest, because of the increasing number of patients sensitized to metals. Using zirconia-toughened ceramics were achieved remarkable development in ceramic knee replacements, a field pioneered by Japanese researchers, because the behavior of these materials allow the production of devices similar in size to the metallic ones. In dentistry, a number of manufacturers are marketing metal-free dental implants, as well as machinable zirconia blanks for the production of crowns, bridges, copings by CAD/CAM. Besides oxides, that in todays’ orthopedics and dentistry are the state-of-the-art bioinert ceramics, silicon nitride has found application in spinal surgery, and investigations in view of its use in joint replacement bearings are in progress.

scholarly journals Coatings Based on Organic/Non-Organic Composites on Bioinert Ceramics by Using Biomimetic Co-Precipitation

Ceramics ◽  
2019 ◽  
Vol 2 (2) ◽  
pp. 260-270 ◽  
Author(s):  
Tomasz Engelmann ◽  
Gaëlle Desante ◽  
Norina Labude ◽  
Stephan Rütten ◽  
Rainer Telle ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Sem Images ◽  
Soaking Time ◽  
Chemical Inertness ◽  
Good Biocompatibility ◽  
Co Precipitation ◽  
Substrate Surfaces ◽  
Bioinert Ceramics ◽  
Standard Protein

Bioinert ceramics have been commonly used in the field of orthopedic and dentistry due to their excellent mechanical properties, esthetic look, good biocompatibility and chemical inertness. However, an activation of its bioinert surface could bring additional advantages for better implant-integration in vivo. Therefore, we introduce an innovative biomimetic co-precipitation technique by using modified simulated body fluid (SBF) to obtain a composite coating made of organic/non-organic components. The zirconia samples were soaked in SBF containing different concentrations of protein (0.01, 0.1, 1, 10 and 100 g/l). Bovine serum albumin (BSA) was applied as a standard protein. During the soaking time, a precipitation of calcium phosphate took place on the substrate surfaces. The proteins were incorporated into the coating during precipitation. Morphology changes of precipitated hydroxyapatite (HAp) due to the presence of proteins were observed on SEM-images. The presence of proteins within the coating was proven by using SEM/energy dispersive X-ray spectroscopy (EDX) and immunohistochemical analysis. We conclude that it is possible to co-precipitate the organic/non-organic composite on inert ceramic by using the wet-chemistry method. In future studies, BSA could be replaced by targeted proteins appropriate to the application area. This method could create new biomaterials, the surfaces of which could be tailored according to the desires and requirements of their use.

Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase

2016 ◽  
Vol 69 ◽  
pp. 184-194 ◽  
Author(s):  
Alieh Aminian ◽  
Bahareh Shirzadi ◽  
Zahra Azizi ◽  
Kathrin Maedler ◽  
Eike Volkmann ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Cell Adhesion ◽  
Cell Membrane ◽  
Osteogenic Cell ◽  
Membrane Enzyme ◽  
Bioinert Ceramics ◽  
Enzyme Alkaline Phosphatase

Osteoconduction of bioceramics in normal and osteopenic rats: Comparison between bioactive and bioinert ceramics

1992 ◽  
Vol 3 (4) ◽  
pp. 259-268 ◽  
Author(s):  
Yasushi Iwashita ◽  
Takao Yamamuro ◽  
Ryuichi Kasai ◽  
Toshiaki Kitsugi ◽  
Takashi Nakamura ◽  
...  
Keyword(s):  
Bioinert Ceramics

Bioinert Ceramics: Zirconia and Alumina

2015 ◽  
pp. 1-25 ◽  
Author(s):  
Corrado Piconi ◽  
Alessandro Alan Porporati
Keyword(s):  
Bioinert Ceramics

scholarly journals Bioactive Ceramics Based on Nb2O5 and Ta2O5

2008 ◽  
Vol 396-398 ◽  
pp. 641-644 ◽  
Author(s):  
C. Marques ◽  
Luis Henrique Leme Louro ◽  
Marcelo Henrique Prado da Silva
Keyword(s):  
Electron Microscopy ◽  
Tissue Engineering ◽  
Scanning Electron Microscopy ◽  
Body Fluid ◽  
X Ray Diffraction ◽  
X Ray ◽  
Bioactive Ceramics ◽  
Metallic Implants ◽  
Bioinert Ceramics ◽  
Scanning Electron

Bioactive ceramics have the ability to chemically bond to bone. This class of biomaterials can be used as coatings on metallic implants, alloplastic bone defect fillers and as scaffold for tissue engineering. The most widely used bioactive ceramics are hydroxyapatite, Ca10(PO4)6(OH)2 and tricalcium phosphate, Ca3(PO4)2. This study presents new bioactive ceramics based on Nb2O5 and Ta2O5. These materials were produced from bioinert ceramics chemically activated by an alkali hydrothermal treatment. Scanning electron microscopy, energy dispersion X-ray spectroscopy and X-ray diffraction analyses on samples incubated in simulated body fluid showed the presence of bone-like apatite, confirming that the modified ceramics surface became bioactive.

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