Relationality Is the Key: The Family of Digital Competencies’ Catalogues and Their Potential Applications

Author(s):  
Małgorzata Kisilowska ◽  
Justyna Jasiewicz ◽  
Anna Mierzecka
Author(s):  
Jyothibabu Sajila Arya ◽  
Malay Krishna Mahato ◽  
Sethuraman Sankararaman ◽  
Prasad Edamana

Graphdiyne, a recent addition to the family of 2D covalent organic nanosheet structure, is known for its structural stability and potential applications in catalysis, sensors, electronics and optoelectronics. Design and...


1995 ◽  
Vol 401 ◽  
Author(s):  
M. E. Hawley ◽  
X. D. Wu ◽  
P. N. Arendt ◽  
C. D. Adams ◽  
M. F. Hundley ◽  
...  

AbstractThe properties encompassed by the family of complex metal oxides span the spectrum from superconductors to insulating ferroelectrics. Included in this family are the new colossal magnetoresistive perovskites with potential applications in advanced high density magnetic data storage devices based on single or multilayer thin films units of these materials fabricated by vapor phase deposition (PVD) methods. The realization of this potential requires solving basic thin film materials problems requiring understanding and controlling the growth of these materials. Toward this end, we have grown La0.7Ca0.3MnO3 and La0.7Sr0.3MnO3 on LaAlO3 single crystal substrates by pulsed laser and RF sputter deposition at temperatures from 500° C to 900° C and annealed at over 900° C for about 10 hours. The evolution of the microstructure of these films was studied by scanning probe microscopies and transmission electron microscopy (TEM).The results of SPM characterization showed that at the lower end of the growth temperature range, the as-grown films were polygranular with grain size increasing with temperature. The 500° C as-grown films appeared to be amorphous while the 750° C film grains were layered with terrace steps often one unit cell high. In contrast, films grown at 900° C consisted of coalesced islands with some 3-D surface crystals. After annealing, all films had coalesced into very large extended layered islands. The change in microstructure was reflected in a decreased resistivity of coalesced films over their unannealed granular precursors. Previous reported work on the growth of La0.84 Sr0.16MnO3 and La0.8Sr0 2CoO3 grown demonstrated the sensitivity of the microstructure to substrate and deposition conditions. Films grown on an “accidental” vicinal surface grew by a step flow mechanism.


1991 ◽  
Vol 56 (1) ◽  
pp. 276-294 ◽  
Author(s):  
Arnon Avron

Many-valued logics in general and 3-valued logic in particular is an old subject which had its beginning in the work of Łukasiewicz [Łuk]. Recently there is a revived interest in this topic, both for its own sake (see, for example, [Ho]), and also because of its potential applications in several areas of computer science, such as proving correctness of programs [Jo], knowledge bases [CP] and artificial intelligence [Tu]. There are, however, a huge number of 3-valued systems which logicians have studied throughout the years. The motivation behind them and their properties are not always clear, and their proof theory is frequently not well developed. This state of affairs makes both the use of 3-valued logics and doing fruitful research on them rather difficult.Our first goal in this work is, accordingly, to identify and characterize a class of 3-valued logics which might be called natural. For this we use the general framework for characterizing and investigating logics which we have developed in [Av1]. Not many 3-valued logics appear as natural within this framework, but it turns out that those that do include some of the best known ones. These include the 3-valued logics of Łukasiewicz, Kleene and Sobociński, the logic LPF used in the VDM project, the logic RM3 from the relevance family and the paraconsistent 3-valued logic of [dCA]. Our presentation provides justifications for the introduction of certain connectives in these logics which are often regarded as ad hoc. It also shows that they are all closely related to each other. It is shown, for example, that Łukasiewicz 3-valued logic and RM3 (the strongest logic in the family of relevance logics) are in a strong sense dual to each other, and that both are derivable by the same general construction from, respectively, Kleene 3-valued logic and the 3-valued paraconsistent logic.


Author(s):  
G. C. Ibeh ◽  
E. J. Ekpenyoung ◽  
K. Anyiam ◽  
C. John

This study introduces a new distribution in the family of generalized exponential distributions generated using the transformed-transformer method. Some properties of the distribution are presented. The new distribution has three parameters and they are estimated numerically using the BGFS iterative method implemented in R software. Two real sets of data are adopted to demonstrate the flexibility and potential applications of the new distribution.


Catalysts ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 476
Author(s):  
María Gimeno-Pérez ◽  
Zoran Merdzo ◽  
Eva Castillo-Rosa ◽  
Carlos Martín de Hijas ◽  
María Fernández-Lobato

The β-fructofuranosidase from the yeast Rhodotorula dairenensis (RdINV) produces a mixture of potential prebiotic fructooligosaccharides (FOS) of the levan-, inulin- and neo-FOS series by transfructosylation of sucrose. In this work, the gene responsible for this activity was characterized and its functionality proved in Pichia pastoris. The amino acid sequence of the new protein contained most of the characteristic elements of β-fructofuranosidases included in the family 32 of the glycosyl hydrolases (GH32). The heterologous yeast produced a protein of about 170 kDa, where N-linked and O-linked carbohydrates constituted about 15% and 38% of the total protein mass, respectively. Biochemical and kinetic properties of the heterologous protein were similar to the native enzyme, including its ability to produce prebiotic sugars. The maximum concentration of FOS obtained was 82.2 g/L, of which 6-kestose represented about 59% (w/w) of the total products synthesized. The potential of RdINV to fructosylate 19 hydroxylated compounds was also explored, of which eight sugars and four alditols were modified. The flexibility to recognize diverse fructosyl acceptors makes this protein valuable to produce novel glycosyl-compounds with potential applications in food and pharmaceutical industries.


2020 ◽  
Vol 86 (10) ◽  
Author(s):  
Madhura Shettigar ◽  
Sahil Balotra ◽  
Annette Kasprzak ◽  
Stephen L. Pearce ◽  
Michael J. Lacey ◽  
...  

ABSTRACT Burkholderia sp. strain SG-MS1 and Pseudomonas sp. strain SG-MS2 have previously been found to mineralize (+)-pinoresinol through a common catabolic pathway. Here, we used comparative genomics, proteomics, protein semipurification, and heterologous expression to identify a flavoprotein from the vanillyl alcohol oxidase/p-cresol methyl hydroxylase (VAO/PCMH) enzyme family in SG-MS2 that carries out the initial hydroxylation of (+)-pinoresinol at the benzylic carbon. The cognate gene is translationally coupled with a downstream cytochrome gene, and the cytochrome is required for activity. The flavoprotein has a unique combination of cofactor binding and cytochrome requirements for the VAO/PCMH family. The heterologously expressed enzyme has a Km of 1.17 μM for (+)-pinoresinol. The enzyme is overexpressed in strain SG-MS2 upon exposure to (+)-pinoresinol, along with 45 other proteins, 22 of which were found to be encoded by genes in an approximately 35.1-kb cluster also containing the flavoprotein and cytochrome genes. Homologs of 18 of these 22 genes, plus the flavoprotein and cytochrome genes, were also found in a 38.7-kb cluster in SG-MS1. The amino acid identities of four of the other proteins within the SG-MS2 cluster suggest they catalyze conversion of hydroxylated pinoresinol to protocatechuate and 2-methoxyhydroquinone. Nine other proteins upregulated in SG-MS2 on exposure to (+)-pinoresinol appear to be homologs of proteins known to comprise the protocatechuate and 2-methoxyhydroquinone catabolic pathways, but only three of the cognate genes lie within the cluster containing the flavoprotein and cytochrome genes. IMPORTANCE (+)-Pinoresinol is an important plant defense compound, a major food lignan for humans and some other animals, and the model compound used to study degradation of the β-β′ linkages in lignin. We report a gene cluster, in one strain each of Pseudomonas and Burkholderia, that is involved in the oxidative catabolism of (+)-pinoresinol. The flavoprotein component of the α-hydroxylase which heads the pathway belongs to the 4-phenol oxidizing (4PO) subgroup of the vanillyl alcohol oxidase/p-cresol methyl hydroxylase (VAO/PCMH) enzyme family but constitutes a novel combination of cofactor and electron acceptor properties for the family. It is translationally coupled with a cytochrome gene whose product is also required for activity. The work casts new light on the biology of (+)-pinoresinol and its transformation to other bioactive molecules. Potential applications of the findings include new options for deconstructing lignin into useful chemicals and the generation of new phytoestrogenic enterolactones from lignans.


Mathematics ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 2113
Author(s):  
Saisai Ding ◽  
Xiaoqin Li ◽  
Xiang Dong ◽  
Wenzhi Yang

In this paper, we investigate the CUSUM-type estimator of mean change-point models based on m-asymptotically almost negatively associated (m-AANA) sequences. The family of m-AANA sequences contains AANA, NA, m-NA, and independent sequences as special cases. Under some weak conditions, some convergence rates are obtained such as OP(n1/p−1), OP(n1/p−1log1/pn) and OP(nα−1), where 0≤α<1 and 1<p≤2. Our rates are better than the ones obtained by Kokoszka and Leipus (Stat. Probab. Lett., 1998, 40, 385–393). In order to illustrate our results, we do perform simulations based on m-AANA sequences. As important applications, we use the CUSUM-type estimator to do the change-point analysis based on three real data such as Quebec temperature, Nile flow, and stock returns for Tesla. Some potential applications to change-point models in finance and economics are also discussed in this paper.


Author(s):  
Carolina Sartorio

This article examines potential applications of the concept of cause to some central ethical concepts, views, and problems. In particular, it discusses the role of causation in the family of views known as consequentialism, the distinction between killing and letting die, the doctrine of double effect, and the concept of moral responsibility. The article aims to examine the extent to which an appeal to the concept of cause contributes to elucidating moral notions or to increasing the plausibility of moral views. Something that makes this task interestingly complex is the fact that the notion of causation itself is controversial and difficult to pin down. As a result, in some cases the success of its use in moral theory hinges on how certain debates about causation are resolved.


2016 ◽  
Vol 141 (10) ◽  
pp. 1428-1433 ◽  
Author(s):  
Kyra B. Berg ◽  
David F. Schaeffer

SATB2 is part of the family of matrix attachment region–binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively narrow expression profile in malignancies, including colorectal/appendiceal adenocarcinomas, tumors of osteoblastic differentiation, and renal/urothelial carcinomas. SATB2 has gained interest as a relatively specific marker of colorectal differentiation, with potential applications including determining origin of adenocarcinomas of unknown primary and distinguishing primary ovarian mucinous adenocarcinomas from colorectal metastases. Here, we briefly review the biology, expression profile, and potential histologic applications of SATB2.


2005 ◽  
Vol 872 ◽  
Author(s):  
Yue Zhang ◽  
Jian He ◽  
Yunhua Huang ◽  
Yousong Gu ◽  
Zhen Ji ◽  
...  

AbstractWe developed an efficient method in achieving a wide range of high-quality ZnO nanostructures by zinc powder evaporation at lower temperature. The synthesis under specific conditions of ZnO nanostructures, such as comb-like structures, well-aligned nanorods, nanonails and core-shell ZnO/SiOx nanowires, were introduced in detailed respectively in this letter. Meanwhile, SEM, TEM, HRTEM and EDX investigations were performed on the products and revealed the crystal structure and the growth mechanism. These high-quality nanostructures enriched the family of ZnO nanomaterials and may have potential applications in optoelectronics, sensors and nanoscale mechanics research.


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