Functional expression of an Fc receptor cloned from neonatal rat small intestine

1990 ◽  
pp. 293-297
Author(s):  
N E Simister ◽  
K E Mostov
Keyword(s):  
Small Intestine ◽  
Functional Expression ◽  
Fc Receptor ◽  
Neonatal Rat ◽  
Rat Small Intestine

scholarly journals Electron tomography of late stages of FcRn-mediated antibody transcytosis in neonatal rat small intestine

2012 ◽  
Vol 23 (13) ◽  
pp. 2537-2545 ◽  
Author(s):  
Mark S. Ladinsky ◽  
Kathryn E. Huey-Tubman ◽  
Pamela J. Bjorkman
Keyword(s):  
Small Intestine ◽  
Intercellular Space ◽  
Electron Tomography ◽  
Neonatal Rat ◽  
Passive Immunity ◽  
Multivesicular Bodies ◽  
Rat Jejunum ◽  
Rat Small Intestine ◽  
Neonatal Fc Receptor ◽  
Late Stages

The neonatal Fc receptor (FcRn) transports maternal immunoglobulin (IgG) across epithelia to confer passive immunity to mammalian young. In newborn rodents, FcRn transcytoses IgG from ingested milk across the intestinal epithelium for release into the bloodstream. We used electron tomography to examine FcRn transport of Nanogold-labeled Fc (Au-Fc) in neonatal rat jejunum, focusing on later aspects of transport by chasing Au-Fc before fixation. We observed pools of Au-Fc in dilated regions of the lateral intercellular space (LIS), likely representing exit sites where Au-Fc accumulates en route to the blood. Before weaning, the jejunum functions primarily in IgG transport and exhibits unusual properties: clathrin-rich regions near/at the basolateral LIS and multivesicular bodies (MVBs) expressing early endosomal markers. To address whether these features are related to IgG transport, we examined LIS and endocytic/transcytotic structures from neonatal and weaned animals. Weaned samples showed less LIS-associated clathrin. MVBs labeled with late endosomal/lysosomal markers were smaller than their neonatal counterparts but contained 10 times more internal compartments. These results are consistent with hypotheses that clathrin-rich basolateral regions in neonatal jejunum are involved in IgG exocytosis and that MVBs function in IgG transport while FcRn is expressed but switch to degradative functions after weaning, when the jejunum does not express FcRn or transport IgG.

Absorption of Zinc Deuteroporphyrin IX 2,4-Bis-GIycol by the Neonatal Rat Small Intestine in vivo

1991 ◽  
Vol 17 (1-2) ◽  
pp. 109-115 ◽  
Author(s):  
Heather A. Vallier ◽  
Pamela A. Rodgers ◽  
Ricardo O. Castillo ◽  
David K. Stevenson
Keyword(s):  
Small Intestine ◽  
Neonatal Rat ◽  
Rat Small Intestine

scholarly journals Cyclic AMP Stimulates Fructose Transport in Neonatal Rat Small Intestine

2004 ◽  
Vol 134 (7) ◽  
pp. 1697-1703 ◽  
Author(s):  
Xue-Lin Cui ◽  
Chris Ananian ◽  
Edwin Perez ◽  
Aidy Strenger ◽  
Annie V. Beuve ◽  
...  
Keyword(s):  
Small Intestine ◽  
Cyclic Amp ◽  
Neonatal Rat ◽  
Rat Small Intestine

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

Anti-inflammatory effect of STW 5, STW 6 and isolated extracts on the rat small intestine

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
K Nieber ◽  
S Michael ◽  
K Grötzinger ◽  
JW Rauwald ◽  
O Kelber
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Oral vanadate reduces Na(+)-dependent glucose transport in rat small intestine

Diabetes ◽  
1993 ◽  
Vol 42 (8) ◽  
pp. 1126-1132 ◽  
Author(s):  
K. L. Madsen ◽  
V. M. Porter ◽  
R. N. Fedorak
Keyword(s):  
Small Intestine ◽  
Glucose Transport ◽  
Rat Small Intestine
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