Developmental Regulation of the Insulin and Insulin-Like Growth Factor Receptors in the Central Nervous System

1993 ◽  
pp. 109-127 ◽  
Author(s):  
Haim Werner ◽  
Charles T. Roberts ◽  
Mohan K. Raizada ◽  
Carolyn A. Bondy ◽  
Martin Adamo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Developmental Regulation ◽  
Growth Factor Receptors ◽  
Insulin Like Growth Factor ◽  
The Central Nervous System

The Biological Role of Truncated Insulin-like Growth Factor-1 and the Tripeptide GPE in the Central Nervous System

1993 ◽  
Vol 692 (1 The Role of I) ◽  
pp. 183-191 ◽  
Author(s):  
VICKI R. SARA ◽  
C. CARLSSON-SKWIRUT ◽  
K. DRAKENBERG ◽  
M. B. GIACOBINI ◽  
L. HÅKANSSON ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Biological Role ◽  
Insulin Like Growth Factor ◽  
The Central Nervous System

Region-specific alterations in insulin-like growth factor-I receptor in the central nervous system of nNOS knockout mice

2004 ◽  
Vol 1021 (1) ◽  
pp. 132-139 ◽  
Author(s):  
Yoon Hee Chung ◽  
Kyeung Min Joo ◽  
Ryoung Hee Nam ◽  
Won Bok Lee ◽  
Kyung Hoon Lee ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Knockout Mice ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
The Central Nervous System ◽  
Growth Factor I

scholarly journals Identification of Gonadulin and Insulin-Like Growth Factor From Migratory Locusts and Their Importance in Reproduction in Locusta migratoria

2021 ◽  
Vol 12 ◽  
Author(s):  
Jan A. Veenstra ◽  
Jimena Leyria ◽  
Ian Orchard ◽  
Angela B. Lange
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Fat Body ◽  
Locusta Migratoria ◽  
Expression Patterns ◽  
Mrna Levels ◽  
Insulin Like Growth Factor ◽  
Oocyte Growth ◽  
The Central Nervous System

Many insect species have several genes coding for insulin-related peptides (IRPs), but so far only a single IRP gene has been identified in migratory locusts. Here, we report and characterize two other genes coding for peptides that are related to insulin, namely gonadulin and arthropod insulin-like growth factor (aIGF); peptides postulated to be orthologs of Drosophila melanogaster insulin-like peptides 8 and 6 respectively. In Locusta migratoria the aIGF transcript is expressed in multiple tissues as was previously reported for IRP in both L. migratoria and Schistocerca gregaria, but there are significant differences in expression patterns between the two species. The gonadulin transcript, however, seems specific to the ovary, whereas its putative receptor transcript is expressed most abundantly in the ovary, fat body and the central nervous system. Since the central nervous system-fat body-ovary axis is essential for successful reproduction, we studied the influence of gonadulin on vitellogenesis and oocyte growth. A reduction in the gonadulin transcript (via RNA interference) led to a significant reduction in vitellogenin mRNA levels in the fat body and a strong oocyte growth inhibition, thus suggesting an important role for gonadulin in reproduction in this species.

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