scholarly journals Acute tryptophan depletion attenuates conscious appraisal of social emotional signals in healthy female volunteers

2010 ◽  
Vol 213 (2-3) ◽  
pp. 603-613 ◽  
Author(s):  
Felix D. C. C. Beacher ◽  
Marcus A. Gray ◽  
Ludovico Minati ◽  
Richard Whale ◽  
Neil A. Harrison ◽  
...  
Keyword(s):  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Social Emotional ◽  
Healthy Female

Biochemical and behavioural effects of acute tryptophan depletion in abstinent bulimic subjects: a pilot study

1995 ◽  
Vol 25 (5) ◽  
pp. 995-1001 ◽  
Author(s):  
A. Oldman ◽  
A. Walsh ◽  
P. Salkovskis ◽  
C. G. Fairburn ◽  
P. J. Cowen
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Free Amino ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Healthy Controls ◽  
Behavioural Effects ◽  
Amino Acid Load ◽  
Healthy Female ◽  
Acid Load

SYNOPSISWe studied the effect of acute tryptophan (TRP) depletion in a group of eight abstinent bulimic (BN) subjects and in 12 healthy female controls. Despite being free of episodes of bingeeating and vomiting for a prolonged period, the abstinent BN subjects still appeared to practice dietary restraint as judged by their food intake in a test meal. In addition, their plasma TRP concentrations were significantly lower than those of the controls. Administration of a TRP-free amino acid load (52 g) significantly lowered plasma total and free TRP. However, compared to a balanced amino acid load, this procedure did not have significant effects on mood, appetite or food intake in either the abstinent BN subjects or the healthy controls.

Acute tryptophan depletion increases experimental nausea but also induces hunger in healthy female subjects

2010 ◽  
Vol 22 (7) ◽  
pp. 752-e220 ◽  
Author(s):  
N. Rieber ◽  
D. Mischler ◽  
V. Schumacher ◽  
E. Muth ◽  
S. Bischoff ◽  
...  
Keyword(s):  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Healthy Female ◽  
Female Subjects

scholarly journals Oxytocinergic modulation of threat-specific amygdala sensitization in humans is critically mediated by serotonergic mechanisms

2020 ◽  
Author(s):  
Congcong Liu ◽  
Chunmei Lan ◽  
Keshuang Li ◽  
Feng Zhou ◽  
Shuxia Yao ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Acute Tryptophan Depletion ◽  
Placebo Control ◽  
Tryptophan Depletion ◽  
Social Emotional ◽  
Double Blind ◽  
Link Type ◽  
Parallel Group ◽  
Emotional Effects

AbstractBackgroundOverarching conceptualizations propose that the complex social-emotional effects of oxytocin (OXT) in humans are partly mediated by interactions with other neurotransmitter systems. Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking.MethodsTo determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, we conducted a parallel-group randomized placebo-controlled double-blind experiment during which n = 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD, TRYP-) or the corresponding placebo-control protocols before the administration of intranasal OXT or placebo intranasal spray, respectively. Mean and repetition-dependent changes in threat-specific amygdala reactivity towards threatening stimuli (angry faces) as assessed by fMRI served as the primary outcome.ResultsNo treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral amygdala threat sensitization to desensitization and this effect was significantly attenuated during decreased central 5-HT signaling via pretreatment with TRYP-.ConclusionsThe present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. OXT may have a therapeutic potential to facilitate amygdala desensitization and adjunct up-regulation of 5-HT neurotransmission may facilitate OXT’s anxiolytic potential.The trial was preregistered on clinicaltrials.gov (https://clinicaltrials.gov/ct2/show/NCT03426176, ID NCT03426176)

Effect of acute tryptophan depletion on mood and appetite in healthy female volunteers

1994 ◽  
Vol 8 (1) ◽  
pp. 8-13 ◽  
Author(s):  
A.D. Oldman ◽  
A.E.S. Walsh ◽  
P. Salkovskis ◽  
D.A. Laver ◽  
P.J. Cowen
Keyword(s):  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Healthy Female

scholarly journals Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [11C]raclopride study in humans

2011 ◽  
Vol 199 (5) ◽  
pp. 391-397 ◽  
Author(s):  
Sylvia M. L. Cox ◽  
Chawki Benkelfat ◽  
Alain Dagher ◽  
J. Scott Delaney ◽  
France Durand ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Comorbid Conditions ◽  
Drug Craving ◽  
Positron Emission ◽  
Wide Range

BackgroundLow serotonin transmission is thought to increase susceptibility to a wide range of substance use disorders and impulsive traits.AimsTo investigate the effects of lowered serotonin on cocaine-induced (1.0 mg/kg cocaine, self-administered intranasally) dopamine responses and drug craving.MethodIn non-dependent cocaine users, serotonin transmission was reduced using the acute tryptophan depletion method. Striatal dopamine responses were measured using positron emission tomography with [11C]raclopride.ResultsAcute tryptophan depletion increased drug craving and striatal dopamine responses to cocaine. These acute tryptophan depletion-induced increases did not occur in the absence of cocaine.ConclusionsThe results suggest that low serotonin transmission can increase dopaminergic and appetitive responses to cocaine. These findings might identify a mechanism by which individuals with low serotonin are at elevated risk for both substance use disorders and comorbid conditions.

scholarly journals Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

2009 ◽  
Vol 16 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Janet S. Carpenter ◽  
Menggang Yu ◽  
Jingwei Wu ◽  
Diane Von Ah ◽  
Jennifer Milata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hot Flashes ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion

B74 THE EFFECTS OF ACUTE TRYPTOPHAN DEPLETION ON BDNF PROTEIN LEVELS IN BRAIN AND SERUM OF MALE AND FEMALE RATS

2005 ◽  
Vol 16 (Supplement 1) ◽  
pp. S89
Author(s):  
E.L. Van Donkelaar ◽  
L.A.W. Jans ◽  
A. Blokland ◽  
N.E.P. Deutz ◽  
G. Kenis ◽  
...  
Keyword(s):  
Female Rats ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Male And Female ◽  
Protein Levels ◽  
Male And Female Rats

scholarly journals Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers

2004 ◽  
Vol 178 (1) ◽  
pp. 92-99 ◽  
Author(s):  
E. A. T. Evers ◽  
D. E. Tillie ◽  
F. M. van der Veen ◽  
C. K. Lieben ◽  
J. Jolles ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Cognitive Performance ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Plasma Tryptophan ◽  
Novel Method
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