scholarly journals Scopolamine fatal outcome in an inmate after buscopan® smoking

2021 ◽  
Author(s):  
Sabina Strano-Rossi ◽  
Serena Mestria ◽  
Giorgio Bolino ◽  
Matteo Polacco ◽  
Simone Grassi ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Drug Abuse ◽  
Muscarinic Receptors ◽  
Histopathological Examination ◽  
Fatal Outcome ◽  
Post Mortem ◽  
Butyl Bromide ◽  
Cannabis Abuse ◽  
Toxic Concentration ◽  
History Of

AbstractScopolamine is an alkaloid which acts as competitive antagonists to acetylcholine at central and peripheral muscarinic receptors. We report the case of a 41-year-old male convict with a 27-year history of cannabis abuse who suddenly died in the bed of his cell after having smoked buscopan® tablets. Since both abuse of substances and recent physical assaults had been reported, we opted for a comprehensive approach (post-mortem computed tomography CT (PMCT), full forensic autopsy, and toxicology testing) to determine which was the cause of the death. Virtopsy found significant cerebral edema and lungs edema that were confirmed at the autopsy and at the histopathological examination. Scopolamine was detected in peripheral blood at the toxic concentration of 14 ng/mL in blood and at 263 ng/mL in urine, and scopolamine butyl bromide at 17 ng/mL in blood and 90 ng/mL in urine. Quetiapine, mirtazapine, lorazepam, diazepam, and metabolites and valproate were also detected (at therapeutic concentrations). Inmates, especially when they have a history of drug abuse, are at risk to use any substance they can find for recreational purposes. In prisons, active surveillance on the management and assumption of prescribed drugs could avoid fatal acute intoxication.

scholarly journals Severe Austrian Syndrome in an Immunocompromised Adult Patient – A Case Report

2018 ◽  
Vol 4 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Ioana Raluca Chirteș ◽  
Dragos Florea ◽  
Carmen Chiriac ◽  
Oana Maria Mărginean ◽  
Cristina Mănășturean ◽  
...  
Keyword(s):  
Case Report ◽  
Streptococcus Pneumoniae ◽  
Histopathological Examination ◽  
Fatal Outcome ◽  
Multiple Organ ◽  
Etiologic Agent ◽  
Acute Meningitis ◽  
History Of ◽  
Valvular Lesions ◽  
Formalin Fixed

AbstractBackground: Known also as Osler’s triad, Austrian syndrome is a complex pathology which consists of pneumonia, meningitis and endocarditis, all caused by the haematogenous dissemination of Streptococcus pneumoniae. The multivalvular lesions are responsible for a severe and potential lethal outcome.Case report: The case of a 51-year-old female patient, with a past medical history of splenectomy, is presented. She developed bronchopneumonia, acute meningitis and infective endocarditis as a result of Streptococcus pneumoniae infection and subsequently developed multiple organ dysfunction syndromes which led to a fatal outcome. Bacteriological tests did not reveal the etiological agent. The histopathological examination showed a severe multivalvular endocarditis, while a PCR based molecular analysis from formalin fixed valvular tissue identified Streptococcus pneumoniae as the etiologic agent.Conclusions: The presented case shows a rare syndrome with a high risk of morbidity and mortality. Following the broad-spectrum treatment and intensive therapeutic support, the patient made unfavourable progress which raised differential diagnosis problems. In this case, the post-mortem diagnosis demonstrated multiple valvular lesions occurred as a result of endocarditis.

scholarly journals Sublingual dermoid: an uncommon presentation and review of literature

2020 ◽  
Vol 7 (1) ◽  
pp. 154
Author(s):  
Hubballi Ravi Kishore ◽  
Reshma P. R.
Keyword(s):  
Computed Tomography ◽  
Dermoid Cyst ◽  
Histopathological Examination ◽  
Floor Of Mouth ◽  
Intraoral Approach ◽  
Uncommon Presentation ◽  
Ultrasound Computed Tomography ◽  
History Of ◽  
Recent Occurrence

<p>Dermoid cysts are generally seen in the areas of embryonic fusion, in the midline, either following sequestration of ectodermal tissue, or due to failure of separation of the ectoderm from the mesoderm during third to fifth weeks of gestation. Patient information: An eighteen year old female patient presented to department of otorhinolaryngology with a painless swelling in the floor of mouth on right side. Physical examination: the swelling was cystic in consistency, bluish in color, translucent, globular shaped, nontender with a right soft submental swelling. Diagnostic assessment: both ultrasound and computed tomography of the swelling was done which reported as ranula. Interventions; under aseptic precautions and general anesthesia, elective excision of the cyst was done by intraoral approach and specimen was sent for histopathological examination. Postoperative period was uneventful. Follow up and outcome: on follow up the patient was stable and the histopathological report revealed dermoid cyst. A lateral to midline presentation of sublingual dermoid cyst in the floor of mouth with recent occurrence of symptoms and no history of any trauma is rare, hence should be considered as one of the differential diagnosis for floor of the mouth cystic swellings. Ranula and dermoid cysts have similar clinical presentation with similar ultrasound, computed tomography and magnetic resonance imaging findings. The only distinguishable investigation is histopathological examination and all the specimens have to be sent for histopathological examination irrespective of the preoperative investigation reports.</p>

scholarly journals Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

2018 ◽  
Vol 18 (3) ◽  
pp. 393
Author(s):  
Rashid S. Al-Umairi ◽  
Fatma Al-Lawati ◽  
Fadhila M. Al-Busaidi
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Histopathological Examination ◽  
Pulmonary Nodules ◽  
Royal Hospital ◽  
Amyloid A ◽  
History Of ◽  
Chest X Ray ◽  
Bilateral Lower Limb ◽  
Pulmonary Amyloidosis

Amyloidosis is a disorder characterised by the extracellular deposition of amyloid, a fibrillary protein, in various organs such as the lungs. Pulmonary nodular amyloidosis can mimic other lung conditions that present with pulmonary nodules, such as metastasis, sarcoidosis and hyalinising granuloma. We report a 60-year-old man who presented to the Royal Hospital, Muscat, Oman, in 2017 with a history of shortness of breath upon exertion, orthopnoea and bilateral lower limb swelling. A chest X-ray showed bilateral nodular opacities. Enhanced chest computed tomography revealed bilateral pulmonary nodules with a predominantly perilymphatic and subpleural distribution, giving the impression of a neoplastic nodule. A histopathological examination of biopsied lung tissue confirmed a diagnosis of nodular pulmonary amyloidosis.Keywords: Multiple Pulmonary Nodules; Amyloidosis; Computed Tomography; Case Report; Oman.

Aneurysms in the history of medicine

VASA ◽  
2002 ◽  
Vol 31 (4) ◽  
pp. 281-286 ◽  
Author(s):  
Bollinger ◽  
Rüttimann
Keyword(s):  
History Of Medicine ◽  
Albert Einstein ◽  
Thomas Mann ◽  
Post Mortem ◽  
John Hunter ◽  
History Of

Die Geschichte des sackförmigen oder fusiformen Aneurysmas reicht in die Zeit der alten Ägypter, Byzantiner und Griechen zurück. Vesal 1557 und Harvey 1628 führten den Begriff in die moderne Medizin ein, indem sie bei je einem Patienten einen pulsierenden Tumor intra vitam feststellten und post mortem verifizierten. Weitere Eckpfeiler bildeten die Monographien von Lancisi und Scarpa im 18. bzw. beginnenden 19. Jahrhundert. Die erste wirksame Therapie bestand in der Kompression des Aneurysmasacks von außen, die zweite in der Arterienligatur, der John Hunter 1785 zum Durchbruch verhalf. Endoaneurysmoraphie (Matas) und Umhüllung mit Folien wurden breit angewendet, bevor Ultraschalldiagnostik und Bypass-Chirurgie Routineverfahren wurden und die Prognose dramatisch verbesserten. Die diagnostischen und therapeutischen Probleme in der Mitte des 20. Jahrhunderts werden anhand von zwei prominenten Patienten dargestellt, Albert Einstein und Thomas Mann, die beide im Jahr 1955 an einer Aneurysmaruptur verstarben.

Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Gruber-Szydlo ◽  
Poreba ◽  
Belowska-Bien ◽  
Derkacz ◽  
Badowski ◽  
...  
Keyword(s):  
Case Report ◽  
Magnetic Resonance Angiography ◽  
Popliteal Artery ◽  
Doppler Ultrasonography ◽  
Histopathological Examination ◽  
Previous History ◽  
Plain Radiography ◽  
Artery Thrombosis ◽  
History Of ◽  
The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

Findings in post mortem computed tomography (PMCT) after cardiac surgery of the adult

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
B Vogel ◽  
H Gulbins ◽  
H Reichenspurner ◽  
A Heinemann ◽  
H Vogel
Keyword(s):  
Computed Tomography ◽  
Cardiac Surgery ◽  
Post Mortem

Congenital heart malformation of new born in post mortem computed tomography

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
B Vogel ◽  
H Gulbins ◽  
H Reichenspurner ◽  
A Heinemann ◽  
H Vogel
Keyword(s):  
Computed Tomography ◽  
Congenital Heart ◽  
Post Mortem ◽  
New Born ◽  
Heart Malformation

Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 76-77
Author(s):  
Mohd Athar ◽  
K S Sodhi ◽  
S Kala ◽  
R K Maurya ◽  
S Chauhan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Natural History ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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