The Effect of Mitochondrial DNA Half-Life on Deletion Mutation Proliferation in Long Lived Cells

2021 ◽  
Author(s):  
Alan G. Holt ◽  
Adrian M. Davies
Keyword(s):  
Mitochondrial Dna ◽  
Half Life ◽  
Deletion Mutation

The relation between d-galactose injection and mitochondrial DNA 4834bp deletion mutation

2006 ◽  
Vol 41 (6) ◽  
pp. 628-634 ◽  
Author(s):  
Wei-jia Kong ◽  
Ying Wang ◽  
Qiong Wang ◽  
Yu-juan Hu ◽  
Yue-chen Han ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Deletion Mutation

Atrial Fibrillation Is Associated With Accumulation of Aging-Related Common Type Mitochondrial DNA Deletion Mutation in Human Atrial Tissue*

CHEST Journal ◽  
2003 ◽  
Vol 123 (2) ◽  
pp. 539-544 ◽  
Author(s):  
Ling-Ping Lai ◽  
Chien-Chen Tsai ◽  
Ming-Jai Su ◽  
Jiunn-Lee Lin ◽  
Yih-Sharng Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Mitochondrial Dna ◽  
Common Type ◽  
Deletion Mutation ◽  
Mitochondrial Dna Deletion ◽  
Dna Deletion ◽  
Atrial Tissue

scholarly journals Detection of the 4 977 bp deletion mutation of mitochondrial DNA in colorectal cancer

2010 ◽  
Vol 18 (27) ◽  
pp. 2934
Author(s):  
Hai-Hong Cui ◽  
Bin Wang ◽  
Ying Han ◽  
Ai-Min Li ◽  
Wei Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mitochondrial Dna ◽  
Deletion Mutation

Corrigendum to “The relation between d-galactose injection and mitochondrial DNA 4834 bp deletion mutation” [Exp. Gerontol. 41(2006) 628–634]

2008 ◽  
Vol 43 (3) ◽  
pp. 245
Author(s):  
Wei-jia Kong ◽  
Ying Wang ◽  
Qiong Wang ◽  
Yu-juan Hu ◽  
Yue-chen Han ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Deletion Mutation

scholarly journals Frequency of Mitochondrial DNA 4977 Deletion Mutation and Their Clinical Characteristics in Patients with Atrial Fibrillation

2011 ◽  
Vol 27 (Supplement) ◽  
pp. OP42_4
Author(s):  
Sook Kyoung Kim ◽  
Kyoung-Jin Shin ◽  
Boyoung Joung ◽  
Moon-Hyoung Lee ◽  
Hui-Nam Pak
Keyword(s):  
Atrial Fibrillation ◽  
Mitochondrial Dna ◽  
Clinical Characteristics ◽  
Deletion Mutation

scholarly journals Muscle Mitochondrial DNA Copy Number, Deletion Mutation Frequency, and Physical Performance in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 889-889
Author(s):  
Jonathan Wanagat ◽  
Allen Herbst ◽  
Steven Prior ◽  
Judd Aiken ◽  
Debbie McKenzie ◽  
...  
Keyword(s):  
Older Adults ◽  
Mitochondrial Dna ◽  
Physical Performance ◽  
Performance Measures ◽  
Copy Number ◽  
Mutation Frequency ◽  
Deletion Mutation ◽  
Mtdna Copy Number ◽  
Mtdna Deletion ◽  
Deletion Frequency

Abstract Mitochondrial DNA (mtDNA) quantity and quality influence hallmarks of aging – mitochondrial dysfunction and genomic instability. The interactions between mtDNA quantity and quality and physical performance have not been extensively examined in humans. The aim of this study was to test the interactions between skeletal muscle mtDNA copy number, mtDNA deletion mutation frequency, and physical performance measures in older adults. Total DNA was isolated from muscle biopsies and used for quantitation of mtDNA copy number and mutation frequency by digital PCR. The biopsies were obtained from a cross-sectional cohort of 53 adults aged 50 to 86 years. Before the biopsy, physical performance measures were collected. MtDNA deletions increased exponentially with advancing age. On average, mtDNA deletion frequency increased 18-fold between 50 and 80, with a trend toward lower deletion frequency in females. MtDNA deletion frequency predicted declines in VO2 max, where 4.7% of the variation in VO2 max was explained by mtDNA deletion frequency. MtDNA copy number was negatively correlated with age and mtDNA deletion frequency, but positively correlated with lean mass. There was a trend to lower mtDNA deletion frequency in females, consistent with increased longevity in females. Larger studies may better delineate sex effects. These data are consistent with a role for mitochondrial function and genome integrity in the maintenance of physical performance with age. Analyses of mtDNA quality and quantity in longitudinal studies could extend our understanding of the importance of mitochondria in human aging and longevity.

Retinal dystrophy associated with a single-base deletion mutation in mitochondrial DNA 3271 in patient with MELAS syndrome

2019 ◽  
Vol 138 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Kenji Ozawa ◽  
Kiyofumi Mochizuki ◽  
Yusuke Manabe ◽  
Nobuaki Yoshikura ◽  
Takayoshi Shimohata ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Retinal Dystrophy ◽  
Deletion Mutation ◽  
Melas Syndrome ◽  
Single Base ◽  
Single Base Deletion
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