Protective effect of Lactobacillus casei HY2782 against particulate matter toxicity in human intestinal CCD-18Co cells and Caenorhabditis elegans

2020 ◽  
Vol 42 (4) ◽  
pp. 519-528
Author(s):  
Joo Yeon Kim ◽  
So Young Lee ◽  
Seung-Hee Jung ◽  
Mi Ri Kim ◽  
Il-Dong Choi ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Caenorhabditis Elegans ◽  
Protective Effect ◽  
Lactobacillus Casei

Protective effect of Annona crassiflora on oxidative stress and Alzheimer’s models in Caenorhabditis elegans

2018 ◽  
Vol 128 ◽  
pp. S125
Author(s):  
Edson Lucas dos Santos ◽  
Natasha Leite ◽  
Laura Costa Alves de Araújo ◽  
José Tarcisio Giffoni de Carvalho ◽  
Kely de Picoli Souza
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Protective Effect ◽  
Annona Crassiflora

scholarly journals Astragalus Polysaccharide Suppresses 6-Hydroxydopamine-Induced Neurotoxicity in Caenorhabditis elegans

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Haifeng Li ◽  
Ruona Shi ◽  
Fei Ding ◽  
Hongyu Wang ◽  
Wenjing Han ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Protective Effect ◽  
Therapeutic Potential ◽  
Neuroprotective Effect ◽  
Acetylcholinesterase Activity ◽  
Apoptosis Pathway ◽  
Acidic Polysaccharide ◽  
C Elegans ◽  
6 Hydroxydopamine

Astragalus membranaceus is a medicinal plant traditionally used in China for a variety of conditions, including inflammatory and neural diseases. Astragalus polysaccharides are shown to reduce the adverse effect of levodopa which is used to treat Parkinson’s disease (PD). However, the neuroprotective effect of Astragalus polysaccharides per se in PD is lacking. Using Caenorhabditis elegans models, we investigated the protective effect of astragalan, an acidic polysaccharide isolated from A. membranaceus, against the neurotoxicity of 6-hydroxydopamine (6-OHDA), a neurotoxin that can induce parkinsonism. We show that 6-OHDA is able to degenerate dopaminergic neurons and lead to the deficiency of food-sensing behavior and a shorter lifespan in C. elegans. Interestingly, these degenerative symptoms can be attenuated by astragalan treatment. Astragalan is also shown to alleviate oxidative stress through reducing reactive oxygen species level and malondialdehyde content and increasing superoxide dismutase and glutathione peroxidase activities and reduce the expression of proapoptotic gene egl-1 in 6-OHDA-intoxicated nematodes. Further studies reveal that astragalan is capable of elevating the decreased acetylcholinesterase activity induced by 6-OHDA. Together, our results demonstrate that the protective effect of astragalan against 6-OHDA neurotoxicity is likely due to the alleviation of oxidative stress and regulation of apoptosis pathway and cholinergic system and thus provide an important insight into the therapeutic potential of Astragalus polysaccharide in neurodegeneration.

Protective Effect of GHX02 Extract on Particulate Matter-Induced Lung Injury

2020 ◽  
Vol 23 (6) ◽  
pp. 611-632
Author(s):  
Won-Kyung Yang ◽  
Yee Ran Lyu ◽  
Seung-Hyung Kim ◽  
Sung-wook Chae ◽  
Ki Mo Kim ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Injury ◽  
Protective Effect

Protective effect of polysaccharides from Pholiota nameko on Lactobacillus casei ATCC 334 subjected to freeze-drying

LWT ◽  
2019 ◽  
Vol 115 ◽  
pp. 108463
Author(s):  
Li Haiping ◽  
Zhao Pei ◽  
Zhang Shuhai ◽  
Zhou Dengyun ◽  
Fu Herong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Lactobacillus Casei ◽  
Freeze Drying ◽  
Pholiota Nameko

scholarly journals Caenorhabditis elegans to Model the Capacity of Ascorbic Acid to Reduce Acute Nitrite Toxicity under Different Feed Conditions: Multivariate Analytics on Behavioral Imaging

2021 ◽  
Vol 18 (4) ◽  
pp. 2068
Author(s):  
Samuel Verdu ◽  
Alberto J. Perez ◽  
Conrado Carrascosa ◽  
José M. Barat ◽  
Pau Talens ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Caenorhabditis Elegans ◽  
Protective Effect ◽  
Animal Health ◽  
Biological Systems ◽  
Meat Products ◽  
Processed Meat ◽  
Multivariate Statistical ◽  
C Elegans ◽  
Nitrite Toxicity

Nitrocompounds are present in the environment and human diet and form part of vegetables and processed meat products as additives. These compounds are related to negative impacts on human and animal health. The protective effect of ascorbic acid has been demonstrated by some biological systems as regards several nitrocompounds. This work focused on studying the possibility of modeling this effect on nitrite toxicity with the model Caenorhabditis elegans. The three factors studied in this work were ascorbic acid concentration, nitrite exposure concentration, and presence/absence of food. The protective effect was evaluated by scoring lethality and its impact on behavior by means of multivariate statistical methods and imaging analytics. The effects of nitrite and the influence of food availability were evidenced. Apart from increasing lethality, nitrite had disruption effects on movements. All the observed symptoms reduced when ascorbic acid was administered, and it diminished lethality in all cases. Ascorbic acid maintained nematodes’ postural capacities. The results suggest that nitrites’ nonspecific toxicity in C. elegans can be mitigated by ascorbic acid, as previously evidenced in other biological systems. Thus, our results reveal the ability of C. elegans to reproduce the known protective effect of ascorbic acid against nitrite.

scholarly journals Catechin-rich Tea Extracts Improve the Lactobacillus casei Growth During Lactic

2012 ◽  
Vol 69 (2) ◽  
Author(s):  
Dan VODNAR ◽  
Floricuța RANGA ◽  
Oana POP ◽  
Carmen SOCACIU
Keyword(s):  
Lactic Acid ◽  
Growth Factors ◽  
Protective Effect ◽  
Health Effects ◽  
Green Tea ◽  
Biomass Production ◽  
Lactobacillus Casei ◽  
Black Tea ◽  
Acid Fermentation ◽  
Phenolics Compounds

Tea is rich in polyphenols and phenolics compounds that have been widely reported to have beneficial health effects. The aim of this study was to investigate the ability of catechins, major phenols in tea, to act as growth factors for Lactobacillus casei during lactic acid fermentation. Major catechins presented in tea extracts are gallocatechin, catechin, epigalocatechin, galocatechingalat, epicatechingalat, catechingalat. Different concentrations of green tea and black tea extracts have been added to MRS model media. Growth and viability of Lactobacillus casei was positively affected by the addition of green tea and black tea extracts. This indicates that green tea and black tea addition exert protective effect on Lactobacillus casei growth in MRS media, increasing the viability and biomass production, probably by acting as metabolic enhancer. This results indicated the posibility of using green tea and black tea as metabolic enhancers for the growth of Lactobacillus casei. 

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