scholarly journals Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka

2011 ◽  
Vol 20 (1) ◽  
pp. 163-176 ◽  
Author(s):  
Haruo Masuyama ◽  
Masato Yamada ◽  
Yasuhiro Kamei ◽  
Tomoko Fujiwara-Ishikawa ◽  
Takeshi Todo ◽  
...  
Keyword(s):  
Sex Determination ◽  
Sex Reversal ◽  
Female Sex ◽  
Male To Female

scholarly journals Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination

PLoS Genetics ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. e1009465
Author(s):  
Sarah L. Whiteley ◽  
Clare E. Holleley ◽  
Susan Wagner ◽  
James Blackburn ◽  
Ira W. Deveson ◽  
...  
Keyword(s):  
Sex Determination ◽  
Model Organism ◽  
Sex Reversal ◽  
Female Development ◽  
Cellular Mechanisms ◽  
Regulatory Pathways ◽  
Female Sex ◽  
Thermally Driven ◽  
Pogona Vitticeps ◽  
Male To Female

How temperature determines sex remains unknown. A recent hypothesis proposes that conserved cellular mechanisms (calcium and redox; ‘CaRe’ status) sense temperature and identify genes and regulatory pathways likely to be involved in driving sexual development. We take advantage of the unique sex determining system of the model organism, Pogona vitticeps, to assess predictions of this hypothesis. P. vitticeps has ZZ male: ZW female sex chromosomes whose influence can be overridden in genetic males by high temperatures, causing male-to-female sex reversal. We compare a developmental transcriptome series of ZWf females and temperature sex reversed ZZf females. We demonstrate that early developmental cascades differ dramatically between genetically driven and thermally driven females, later converging to produce a common outcome (ovaries). We show that genes proposed as regulators of thermosensitive sex determination play a role in temperature sex reversal. Our study greatly advances the search for the mechanisms by which temperature determines sex.

scholarly journals Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determination

2021 ◽  
Author(s):  
Sarah L. Whiteley ◽  
Clare E. Holleley ◽  
Susan Wagner ◽  
James Blackburn ◽  
Ira W. Deveson ◽  
...  
Keyword(s):  
Sex Determination ◽  
Sex Chromosomes ◽  
Model Organism ◽  
Sex Reversal ◽  
Ovary Development ◽  
Cellular Mechanisms ◽  
Regulatory Pathways ◽  
Female Sex ◽  
Thermally Driven ◽  
Male To Female

AbstractHow temperature determines sex remains unknown. A recent hypothesis proposes that conserved cellular mechanisms (calcium and redox; ‘CaRe’ status) sense temperature and identify genes and regulatory pathways likely to be involved in driving sexual development. We take advantage of the unique sex determining system of the model organism, Pogona vitticeps, to assess predictions of this hypothesis. P. vitticeps has ZZ male: ZW female sex chromosomes whose influence can be overridden in genetic males by high temperatures, causing male-to-female sex reversal. We compare a developmental transcriptome series of ZWf females and temperature sex reversed ZZf females. We demonstrate that early developmental cascades differ dramatically between genetically driven and thermally driven females, later converging to produce a common outcome (ovaries). We show that genes proposed as regulators of thermosensitive sex determination play a role in temperature sex reversal. Our study greatly advances the search for the mechanisms by which temperature determines sex.Author SummaryIn many reptiles and fish, environment can determine, or influence, the sex of developing embryos. How this happens at a molecular level that has eluded resolution for half a century of intensive research. We studied the bearded dragon, a lizard that has sex chromosomes (ZZ male and ZW female), but in which that temperature can override ZZ sex chromosomes to cause male to female sex reversal. This provides an unparalleled opportunity to disentangle, in the same species, the biochemical pathways required to make a female by these two different routes. We sequenced the transcriptomes of gonads from developing ZZ reversed and normal ZW dragon embryos and discovered that different sets of genes are active in ovary development driven by genotype or temperature. Females whose sex was initiated by temperature showed a transcriptional profile consistent with the recently-proposed Calcium-Redox hypotheses of cellular temperature sensing. These findings are an important for understanding how the environment influences the development of sex, and more generally how the environment can epigenetically modify the action of genes.

scholarly journals Molecular screening of XY SRY-negative sex reversal cases in horses revealed anomalies in amelogenin testing

2020 ◽  
Vol 32 (6) ◽  
pp. 938-941 ◽  
Author(s):  
Maria M. Martinez ◽  
Mónica Costa ◽  
Cecilia Ratti
Keyword(s):  
Developmental Disorder ◽  
Marker Gene ◽  
Sex Reversal ◽  
Initial Result ◽  
Genetic Constitution ◽  
Female Sex ◽  
Sex Marker ◽  
Xy Sex Reversal ◽  
Dna Genotyping ◽  
Male To Female

Male-to-female sex reversal in horses is a developmental disorder in which phenotypic females have a male genetic constitution. Male-to-female sex reversal is the second most common genetic sex abnormality, after X chromosome monosomy. All male-to-female sex reversal cases studied to date have been found to be infertile. Therefore, a screening test is particularly useful in laboratories doing DNA genotyping in horses. Our laboratory has tested > 209,000 horses for parentage using a panel of microsatellite markers and the sex marker gene amelogenin ( AMEL). Suspect XY sex reversal cases are reported females with a male profile by AMEL testing. After routine genotyping, 49 cases were detected and further tested using the sex-determining region Y ( SRY) gene, confirming the XY SRY-negative genotype of suspect sex reversal cases. When some inconsistencies arose in the initial result, a molecular panel of X- and Y-linked markers was analyzed for these samples. Of the 49 cases, 33 were confirmed as XY SRY-negative. The remaining 16 cases were identified as false-positives as a result of anomalies of AMEL testing in horses.

Male-to-female sex reversal in M33 mutant mice

Nature ◽  
10.1038/31482 ◽  
1998 ◽  
Vol 393 (6686) ◽  
pp. 688-692 ◽  
Author(s):  
Yuko Katoh-Fukui ◽  
Reiko Tsuchiya ◽  
Toshihiko Shiroishi ◽  
Yoko Nakahara ◽  
Naoko Hashimoto ◽  
...  
Keyword(s):  
Sex Reversal ◽  
Mutant Mice ◽  
Female Sex ◽  
Male To Female

scholarly journals Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

Cell ◽  
2001 ◽  
Vol 104 (6) ◽  
pp. 875-889 ◽  
Author(s):  
Jennifer S. Colvin ◽  
Rebecca P. Green ◽  
Jennifer Schmahl ◽  
Blanche Capel ◽  
David M. Ornitz
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Sex Reversal ◽  
Fibroblast Growth ◽  
Female Sex ◽  
Male To Female

A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal

1994 ◽  
Vol 7 (4) ◽  
pp. 497-501 ◽  
Author(s):  
B. Bardoni ◽  
E. Zanaria ◽  
S. Guioli ◽  
G. Floridia ◽  
K. C. Worley ◽  
...  
Keyword(s):  
Sex Reversal ◽  
Female Sex ◽  
Male To Female

A threshold dosage of estrogen for male‐to‐female sex reversal in the Glandirana rugosa frog

2020 ◽  
Vol 333 (9) ◽  
pp. 652-659
Author(s):  
Akira Oike ◽  
Yoriko Nakamura ◽  
Shigeki Yasumasu ◽  
Etsuro Ito ◽  
Masahisa Nakamura
Keyword(s):  
Sex Reversal ◽  
Female Sex ◽  
Male To Female

scholarly journals Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal

2008 ◽  
Vol 17 (19) ◽  
pp. 2949-2955 ◽  
Author(s):  
Danielle M. Maatouk ◽  
Leo DiNapoli ◽  
Ashley Alvers ◽  
Keith L. Parker ◽  
Makoto M. Taketo ◽  
...  
Keyword(s):  
Sex Reversal ◽  
Female Sex ◽  
Male To Female
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