Effects of Diet on Bile Acid Metabolism and Insulin Resistance in Type 2 Diabetic Rats after Roux-en-Y Gastric Bypass

2018 ◽  
Vol 28 (10) ◽  
pp. 3044-3053 ◽  
Author(s):  
Cheng-Xiang Shan ◽  
Nian-Cun Qiu ◽  
Miao-E Liu ◽  
Si-Luo Zha ◽  
Xin Song ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Bile Acid ◽  
Acid Metabolism ◽  
Diabetic Rats ◽  
Bile Acid Metabolism ◽  
Type 2 Diabetic

scholarly journals Influence of gastric bypass on pancreatic insulin resistance in type 2 diabetic rats

2014 ◽  
Vol 22 (10) ◽  
pp. 1431
Author(s):  
Yu-Qing Wen ◽  
Ying-Chun Tan ◽  
Dun-Tao Lv ◽  
Peng-Bo Zhang ◽  
Ze-Qiang Ren
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Diabetic Rats ◽  
Pancreatic Insulin ◽  
Type 2 Diabetic

scholarly journals Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122273 ◽  
Author(s):  
Hina Y Bhutta ◽  
Neetu Rajpal ◽  
Wendy White ◽  
Johannes M. Freudenberg ◽  
Yaping Liu ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bile Acid ◽  
Bypass Surgery ◽  
Acid Metabolism ◽  
Gastric Bypass Surgery ◽  
Diabetic Rats ◽  
Bile Acid Metabolism ◽  
Obese Diabetic Rats

scholarly journals SUN-656 Hypoglycemic Effect of Oral Administered Superoxide Dismutase

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Shutao Liu ◽  
Hangqi Liu
Keyword(s):  
Insulin Resistance ◽  
Superoxide Dismutase ◽  
Resistance Index ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Model Group ◽  
Curative Effect ◽  
Insulin Resistance Index ◽  
Type 2 Diabetic

Abstract Hypoglycemic Effect of Oral Administered Superoxide Dismutase on Type 2 Diabetes via reduction of glucogan and insulin resistance Background & Objective: Superoxide dismutase (SOD) is carefully used in food industry for the concern of its easy degradation and difficult adsorption in digestive tract, although it plays central role in antioxidant system. It is previous reported that orally administered SOD was effective in alleviating hyperglycemia, cerebral ischemia-reperfusion and chronic hepatitis. This work aimed to investigate in-depth the hypoglycaemic effect and possible mechanism of orally administered SOD in the model of type 2 diabetic rats. Methods:The model of type 2 diabetic rats were divided into 6 groups and orally administered with different Cu/Zn-SOD (abbreviated as SOD) samples and negative or positive controls. The 6 groups included SOD, SOD hydrolysate (pepsin-treated SOD), L-SOD (liposome-embedded SOD), model group and metformin positive groups, as well as normal group. Results of the body weight, serum indexes (including blood glucose, glycated albumin, insulin, glucagon, AMPK, MDA), SOD enzymatic activity in organs (liver, heart, kidney, skeletal muscle, spleen, and pancreas) as well as intestinal density and HE staining were measured to evaluate the hypoglycemic effect and possible mechanism. Results: SOD showed substantial hypoglycemic effect and improved serum indicators. Moreover, L-SOD group exhibited better effect than SOD group, though the effect of SOD hydrolysate was not obvious. Colon density and HE staining showed obvious intestinal injury in the model group, and SOD was beneficial to repair intestinal structural integrity. Furthermore, the reparative effect of SOD was much better than that of the SOD hydrolysate, but not as good as that of the L-SOD. The SOD enzymatic activity of tissues was positively correlated with the curative effect of three kinds of SOD samples. The contents of serum MDA were negatively correlated with the curative effect. Compared with the model group, the insulin resistance index of SOD group, L-SOD group and positive group were significantly reduced; and glucagon significantly decreased by 68.38, 77.50 and 65.01%, respectively. Conclusion: Oral SOD showed obvious hypoglycemic effect on type 2 diabetic rats, and liposome could improve this effect. The mechanism may be that SOD effectively reduces intestinal injury, so as to reduce glucongen and insulin resistance index.

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