Liver injury assessment in special populations: challenges remain

2014 ◽  
Vol 1528 (1) ◽  
pp. 9-9
Keyword(s):  
Liver Injury ◽  
Special Populations ◽  
Injury Assessment

1090 DEVELOPMENT AND APPLICATIONS OF A LIVER INJURY ASSESSMENT MODEL BY TRACKING INTERCELLULAR GLUTATHIONE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1304-S-1305
Author(s):  
Hao Li ◽  
Chunxia Liu ◽  
Lu Zhang ◽  
Mu H. Lu ◽  
Mingming Deng ◽  
...  
Keyword(s):  
Liver Injury ◽  
Assessment Model ◽  
Injury Assessment

Influence of small doses of various drug vehicles on acetaminophen-induced liver injury

2010 ◽  
Vol 88 (10) ◽  
pp. 960-967 ◽  
Author(s):  
Tomislav Kelava ◽  
Ivan Ćavar ◽  
Filip Čulo
Keyword(s):  
Liver Injury ◽  
Propylene Glycol ◽  
Reduced Glutathione ◽  
Biological Effects ◽  
Tween 20 ◽  
Histopathological Changes ◽  
Acetaminophen Toxicity ◽  
Small Doses ◽  
Injury Assessment ◽  
Drug Vehicle

The biological effects of drug vehicles are often overlooked, often leading to artifacts in acetaminophen-induced liver injury assessment. Therefore, we decided to investigate the effect of dimethylsulfoxide, dimethylformamide, propylene glycol, ethanol, and Tween 20 on acetaminophen-induced liver injury. C57BL/6 male mice received a particular drug vehicle (0.6 or 0.2 mL/kg, i.p.) 30 min before acetaminophen administration (300 mg/kg, i.p.). Control mice received vehicle alone. Liver injury was assessed by measuring the concentration of alanine aminotransferase in plasma and observing histopathological changes. The level of reduced glutathione (GSH) was assessed by measuring total nonprotein hepatic sulfhydrils. Dimethylsulfoxide and dimethylformamide (at both doses) almost completely abolished acetaminophen toxicity. The higher dose of propylene glycol (0.6 mL/kg) was markedly protective, but the lower dose (0.2 mL/kg) was only slightly protective. These solvents also reduced acetaminophen-induced GSH depletion. Dimethylformamide was protective when given 2 h before or 1 h after acetaminophen administration, but was ineffective if given 2.5 h after acetaminophen. Ethanol at the higher dose (0.6 mL/kg) was partially protective, whereas ethanol at the lower dose (0.2 mL/kg) as well as Tween 20 at any dose had no influence. None of the vehicles (0.6 mL/kg) was hepatotoxic per se, and none of them was protective in a model of liver injury caused by d-galactosamine and lipopolysaccharide.

scholarly journals Hepatitis E Virus, A Diagnosis to Consider in Drug Induced Liver Injury Assessment

2017 ◽  
Vol 39 (8) ◽  
pp. e56-e57
Author(s):  
J. Sanabria-Cabrera ◽  
R. Sanjuan-Jiménez ◽  
C. Stephens ◽  
M. Robles-Díaz ◽  
A. Ortega-Alonso ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Assessment

Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

ACS Sensors ◽  
2021 ◽  
Author(s):  
Jiao Chen ◽  
Dongyu Huang ◽  
Mengyao She ◽  
Zesi Wang ◽  
Xi Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Recent Progress ◽  
Fluorescent Sensors ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Assessment

Effects of Steroids on Fetal Rat Liver

1969 ◽  
Vol 27 ◽  
pp. 350-351
Author(s):  
F. G. Zaki
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Fetal Liver ◽  
Dosage Level ◽  
Maternal Plasma ◽  
Methyl Prednisolone ◽  
Fetal Rat ◽  
Toxic Agents ◽  
Fetal Rat Liver ◽  
Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

Sports Concussions (TBI), Imbalance, and Dizziness

2015 ◽  
Vol 25 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Steven M. Doettl
Keyword(s):  
Assessment Tools ◽  
Vestibular Evoked Myogenic Potentials ◽  
Post Injury ◽  
Management Tools ◽  
Concussion Management ◽  
Post Concussion Syndrome ◽  
Behavioral Marker ◽  
Valid Assessment ◽  
Injury Assessment

It has been widely accepted that the assessment of balance after concussion plays a large role in determining deficit. Qualitative balance assessments have been an established piece of the post-injury assessment as a clinical behavioral marker of concussion for many years. Recently more specific guidelines outlining the role of balance evaluation in concussion identification and management have been developed as part of concussion management tools. As part of the ongoing development of concussions protocols, quantitative assessment of balance function following concussion has also been identified to have an important role. Frequently imbalance and dizziness reported following concussion is assumed to be associated with post-concussion syndrome (PCS). While imbalance and dizziness are common complaints in PCS, they can also be a sign of additional underlying pathology. In cases of specific dizziness symptoms or limited balance recovery beyond the initial post-concussive period, a quantitative vestibular assessment may also be needed. Electronystagmography and videonystagmography (ENG/VNG), rotary chair testing (RCT), and vestibular evoked myogenic potentials (VEMPs) have all been identified as valid assessment tools for vestibular dysfunction following traumatic brain injury (TBI). The assessment of balance and dizziness following sports-related concussions is an integral piece of the puzzle for removal from play, assessment of severity, and management.

Proteinase activated receptor (PAR)-2 agonistic peptide protects from Th-1 mediated liver injury in mice

2001 ◽  
Vol 120 (5) ◽  
pp. A27-A27
Author(s):  
S FLORUCCI ◽  
A MENCARELLI ◽  
B PALAZZETTI ◽  
E DISTRUTTI ◽  
G CIRINO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Th 1
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