A BODIPY-modified polymeric micelle for sustaining enhanced photodynamic therapy

2021 ◽  
Author(s):  
Yun-Chang Zhang ◽  
Lan She ◽  
Zi-Yue Xu ◽  
Ze-Kun Wang ◽  
Zhiqiang Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelle

Synthesis of Hemoglobin Conjugated Polymeric Micelle: A ZnPc Carrier with Oxygen Self-Compensating Ability for Photodynamic Therapy

2015 ◽  
Vol 16 (9) ◽  
pp. 2693-2700 ◽  
Author(s):  
Shasha Wang ◽  
Fang Yuan ◽  
Kui Chen ◽  
Gaojian Chen ◽  
Kehua Tu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelle

scholarly journals Photodynamic Therapy (PDT) and Diagnosis (PDD) with a Dendrimer Photosensitizer-encapsulated Polymeric Micelle

2012 ◽  
Vol 33 (2) ◽  
pp. 104-109
Author(s):  
Hitomi Hiruma ◽  
Yuji Morimoto ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
Takahiro Nomoto ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelle

Near infrared imaging-guided photodynamic therapy under an extremely low energy of light by galactose targeted amphiphilic polypeptide micelle encapsulating BODIPY-Br2

2016 ◽  
Vol 4 (11) ◽  
pp. 1638-1645 ◽  
Author(s):  
Le Liu ◽  
Zheng Ruan ◽  
Tuanwei Li ◽  
Pan Yuan ◽  
Lifeng Yan
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Polymeric Micelle ◽  
Low Energy ◽  
Near Infrared Imaging ◽  
Nir Imaging

Galactose targeted polymeric micelle encapsulating BODIPY-Br2 has been prepared which showed NIR imaging-guided photodynamic therapy under an extremely low energy of light.

scholarly journals Folate-Targeted Curcumin-Encapsulated Micellar Nanosystem for Chemotherapy and Curcumin-Mediated Photodynamic Therapy

Polymers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2280
Author(s):  
Yun Hsuan Lin ◽  
Ching-Yi Chen
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
High Efficiency ◽  
Folate Receptor ◽  
Drug Loading ◽  
Aqueous Solubility ◽  
Polymeric Micelle ◽  
In Vitro Cytotoxicity ◽  
Efficient Delivery

Curcumin (CUR) is a natural phenolic product used as a high-efficiency and low-toxicity anticancer drug and photosensitizer. However, it has a poor aqueous solubility and a lack of target specificity, which limits its clinical applications. Hence, we developed a folate-conjugated polymeric micelle to enhance the efficient delivery of CUR for effective cancer cell targeting and anticancer efficiency. A series of biocompatible folate-conjugated poly(2-(methacryloyloxy)ethylphosphoryl- choline)-b-poly(ε-caprolactone) (FPM) was synthesized with different hydrophobic lengths and folate contents. The prepared CUR-loaded micelles (CUR-FPM) possessed several superior properties, including an excellent drug loading capacity (6.3 ± 1.2%), improved CUR aqueous stability, fast-sustained CUR release in an acidic environment, and efficient intracellular production of reactive oxygen species. The in vitro cytotoxicity demonstrated that the CUR-FPM micelles efficiently suppressed the growth of HeLa cells (folate-receptor overexpression) compared to that of HT-29 cells, and a competition study showed less cytotoxic effect when free folic acid blocked the folate receptor, indicating the folate conjugation played the role of targeting the specific cells well. Moreover, the CUR-mediated photodynamic therapy (PDT) by CUR-FPM micelles under irradiation further inhibited the proliferation of cancer cells. All these results indicate that the CUR-FPM micelles could be a promising delivery system for folate-overexpressing cancer cells, complementary chemotherapy, and CUR-mediated photodynamic therapy.

Self-guiding Polymeric Prodrug Micelles with Two AIE Photosensitizers for Enhanced Chemo-Photodynamic Therapy

2020 ◽  
Author(s):  
Xiaoqing Yi ◽  
Xiaoding Lou ◽  
Zujin Zhao ◽  
Fan Xia ◽  
Ben Zhong Tang
Keyword(s):  
Photodynamic Therapy ◽  
Cellular Uptake ◽  
Continuous Light ◽  
Polymeric Micelle ◽  
Light Irradiation ◽  
Fluorescence Signal ◽  
Aggregation State ◽  
Dual Stage

<p>Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N<sub>3</sub>) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L<sub>1</sub>, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L<sub>2</sub>, 18 min) for sufficient ROS production, but also monitor the non-fluorescent drug PTX release in turn. Both <i>in vivo</i> and <i>in vitro</i> studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited superior therapeutic effect than only 24-min continuous light irradiation.</p>

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

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