Intraoperative brain mapping of language, cognitive functions, and social cognition in awake surgery of low-grade gliomas located in the right non-dominant hemisphere

2021 ◽  
Vol 200 ◽  
pp. 106363
Author(s):  
Ricardo Prat-Acín ◽  
Inma Galeano-Senabre ◽  
Pilar López-Ruiz ◽  
Angel Ayuso-Sacido ◽  
Raul Espert-Tortajada
Keyword(s):  
Social Cognition ◽  
Brain Mapping ◽  
Cognitive Functions ◽  
Awake Surgery ◽  
Low Grade ◽  
Dominant Hemisphere ◽  
Low Grade Gliomas ◽  
The Right

Involvement of the right inferior longitudinal fascicle in visual hemiagnosia: a brain stimulation mapping study

2013 ◽  
Vol 118 (1) ◽  
pp. 202-205 ◽  
Author(s):  
Alejandro Fernández Coello ◽  
Sophie Duvaux ◽  
Alessandro De Benedictis ◽  
Ryosuke Matsuda ◽  
Hugues Duffau
Keyword(s):  
Brain Stimulation ◽  
Brain Mapping ◽  
Visual Recognition ◽  
Awake Surgery ◽  
Low Grade ◽  
Mapping Study ◽  
Visual Agnosia ◽  
The Right ◽  
Tractography Data

Neural foundations underlying visual agnosia are poorly understood. The authors present the case of a patient who underwent awake surgery for a right basal temporooccipital low-grade glioma in which direct electrostimulation was used both at the cortical and subcortical level. Brain mapping over the inferior longitudinal fascicle generated contralateral visual hemiagnosia. These original findings are in agreement with recent tractography data that have confirmed the existence of an occipitotemporal pathway connecting occipital visual input to higher-level processing in temporal lobe structures. This is the first report of a true transient visual hemiagnosia elicited through electrostimulation, supporting the crucial role of inferior longitudinal fascicle in visual recognition.

Cognitive functions in low-grade gliomas: disease and treatment effects

2006 ◽  
Vol 81 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Denise D. Correa ◽  
Lisa M. DeAngelis ◽  
Weiji Shi ◽  
Howard T. Thaler ◽  
Michael Lin ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Treatment Effects ◽  
Low Grade ◽  
Low Grade Gliomas

scholarly journals LGG-05. MOLECULAR GUIDED THERAPY FOR A PEDIATRIC LOW GRADE GLIOMA: A CASE REPORT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii367-iii367
Author(s):  
Jayne VonBergen ◽  
Beth Armstrong ◽  
Morgan Schmitt
Keyword(s):  
Targeted Therapy ◽  
Standard Treatment ◽  
Head Tilt ◽  
Study Patient ◽  
Low Grade ◽  
Temporal Region ◽  
Low Grade Gliomas ◽  
Leptomeningeal Involvement ◽  
The Right ◽  
Guided Therapy

Abstract Low grade gliomas are the most common type of central nervous system tumors among children. Despite the fact that they are not typically life threatening, low grade gliomas remain a significant clinical challenge. Case Study: Patient is a 4-year-old male who presented at 20 months of age with several weeks of ataxia, emesis, and head tilt. Imaging revealed a right temporal lobe lesion; he was subsequently taken to surgery, where a gross total resection was achieved. Imaging 9 months post resection revealed recurrent disease within the right temporal region with leptomeningeal involvement. Four months later imaging revealed progression of multifocal disease and new growth within the sella. At this time the patient started standard treatment, Carboplatin and Vincristine, per CCG 9952A. Persistent slow progression was observed despite receiving standard therapy. The patient developed a grade 3 reaction to carboplatin, worsening with each subsequent dose. At this time, he was referred to our Precision Genomics Neuro Oncology program for tumor molecular characterization. Somatic tumor testing revealed an ETV6-NTRK3 fusion, at which time standard treatment was stopped, and patient began targeted therapy, Larotrectinib. Imaging was preformed 2 months post start of targeted therapy and revealed interval decrease in size of previously enhancing nodular lesions; findings consistent with treatment response. Disease burden continues to decrease with therapy. This case illustrates a clear benefit of using molecular guided therapy in low grade gliomas.

Disrupting the right pars opercularis with electrical stimulation frees the song: case report

2015 ◽  
Vol 123 (6) ◽  
pp. 1401-1404 ◽  
Author(s):  
Guillaume Herbet ◽  
Gilles Lafargue ◽  
Fabien Almairac ◽  
Sylvie Moritz-Gasser ◽  
François Bonnetblanc ◽  
...  
Keyword(s):  
Language Production ◽  
Inferior Frontal Gyrus ◽  
Awake Surgery ◽  
Low Grade ◽  
Speech Impairment ◽  
First Case ◽  
Pars Opercularis ◽  
The Right

The authors report the first case of a strikingly unusual speech impairment evoked by intraoperative electrostimulation in a 36-year-old right-handed patient, a well-trained singer, who underwent awake surgery for a right fronto-temporo-insular low-grade glioma. Functionally disrupting the pars opercularis of the right inferior frontal gyrus led the patient to automatically switch from a speaking to a singing mode of language production. Given the central role of the right pars opercularis in the inhibitory control network, the authors propose that this finding may be interpreted as possible evidence for a competitive and independent neurocognitive subnetwork devoted to the melodically intoned articulation of words (normal language-based vs singing-based) in subjects with high expertise. From a more clinical perspective, such data may have implications for awake neurosurgery, especially to preserve the quality of life for singers.

Virtual Reality-assisted awake brain mapping. (Preprint)

2021 ◽  
Author(s):  
Florian Bernard ◽  
Morgane Casanova ◽  
Anne Clavreul ◽  
Ghislaine Aubin ◽  
Gwenaelle Soulard ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Social Cognition ◽  
Visual Field ◽  
Brain Mapping ◽  
Cognitive Functions ◽  
Total Duration ◽  
Spatial Neglect ◽  
Brain Surgery ◽  
Duration Of Surgery ◽  
The Mean

BACKGROUND Preserving major cognitive functions, such as visuo-spatial and social cognition in the surgical management of brain tumors could be decisive for the postoperative quality of life. Using virtual reality during awake brain surgery appears to be interesting for preserving complex cognitive functions. Developing neuropsychological tasks appropriate for use during awake brain surgery using virtual reality technology is challenging. OBJECTIVE In this paper, we describe our preliminary experience of extending progressively complex cognitive paradigms via dynamic VR environments during 68 peri-operative brain mapping. METHODS This is a single center, retrospective longitudinal study, concerning two cohorts. RESULTS A total of 65 patients (30 women, mean age 49.7, range 23-75) operated with VR-assisted Brain mapping were included. At least one VR task (VR-DO 80, VR Estermann or VR-TANGO task) during DES were done for all the patients. The mean duration of surgery was 4 h 30 min, the mean duration of the awake phase was 2 h 15 min. The mean intensity used for DES was 3 mA (Intensity from 0,5 to 8 mA). Mean total duration of VRH use per patient at 16 min (from 10 to 37 min). VR task allowed to preserve language, visual field, visuospatial and social cognition in our serie. CONCLUSIONS We show through illustrative cases how VR opens new possibilities for the mapping of complex cognitive functions within the operating theater. CLINICALTRIAL ClinicalTrials.gov NCT03010943Virtual reality; awake neurosurgery; visual field; social cognition; visuospatial cognition; unilateral spatial neglect. INTERNATIONAL REGISTERED REPORT RR2-10.2196/10332.

Hypnosis for Awake Surgery of Low-grade Gliomas

Neurosurgery ◽  
2015 ◽  
Vol 78 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Ilyess Zemmoura ◽  
Eric Fournier ◽  
Wissam El-Hage ◽  
Virginie Jolly ◽  
Christophe Destrieux ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Perceived Stress ◽  
Stress Disorder ◽  
Awake Surgery ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Stress Scale ◽  
Dissociative Experience ◽  
Experience Questionnaire

Abstract BACKGROUND: Awake craniotomy with intraoperative electric stimulation is a reliable method for extensive removal of low-grade gliomas while preserving the functional integrity of eloquent surrounding brain structures. Although fully awake procedures have been proposed, asleep-awake-asleep remains the standard technique. Anesthetic contraindications are the only limitation of this method, which is therefore not reliable for older patients with high-grade gliomas. OBJECTIVE: To describe and assess a novel method for awake craniotomy based on hypnosis. METHODS: We proposed a novel hypnosedation procedure to patients undergoing awake surgery for low-grade gliomas in our institution between May 2011 and April 2015. Surgical data were retrospectively recorded. The subjective experience of hypnosis was assessed by 3 standardized questionnaires: the Cohen Perceived Stress Scale, the Posttraumatic Stress Disorder Checklist Scale, the Peritraumatic Dissociative Experience Questionnaire, and a fourth questionnaire designed specifically for this study. RESULTS: Twenty-eight questionnaires were retrieved from 43 procedures performed on 37 patients. The Peritraumatic Dissociative Experience Questionnaire revealed a dissociation state in 17 cases. The Perceived Stress Scale was pathological in 8 patients. Two patients in this group stated that they would not accept a second hypnosedation procedure. The Posttraumatic Stress Disorder Checklist Scale revealed 1 case of posttraumatic stress disorder. Burr hole and bone flap procedures were the most frequently reported unpleasant events during opening (15 of 52 events). CONCLUSION: The main findings of our study are the effectiveness of the technique, which in all cases allowed resection of the tumor up to functional boundaries, and the positive psychological impact of the technique in most of the patients.

scholarly journals Letter: Hypnosis for Awake Surgery of Low-Grade Gliomas: Description of the Method and Psychological Assessment

Neurosurgery ◽  
2017 ◽  
Vol 80 (2) ◽  
pp. E186-E186
Author(s):  
Mohamed Srairi ◽  
Ségolène Mrozek ◽  
Franck Roux ◽  
Thomas Geeraerts
Keyword(s):  
Psychological Assessment ◽  
Awake Surgery ◽  
Low Grade ◽  
Low Grade Gliomas

Cognitive functions and quality of life in patients with low-grade gliomas: The impact of radiotherapy

1994 ◽  
Vol 36 (1) ◽  
pp. 48-54 ◽  
Author(s):  
M. J. B. Taphoorn ◽  
A. Klein Schiphorst ◽  
F. J. Snoek ◽  
J. Lindeboom ◽  
J. G. Wolbers ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Functions ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
The Impact
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