Nanoparticles with specific bioadhesive properties to circumvent the pre-systemic degradation of fluorinated pyrimidines

2004 ◽  
Vol 96 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Pau Arbós ◽  
Miguel Angel Campanero ◽  
Miguel Angel Arangoa ◽  
Juan M. Irache
Keyword(s):  
Fluorinated Pyrimidines ◽  
Systemic Degradation

UKRAINIAN POLITICAL PROJECT: FROM GOVERNMENT INSUFFICIENCY TO SOCIAL DEGRADATION

2019 ◽  
Author(s):  
А.А. CHEMSHIT ◽  
О.S. STATSENKO
Keyword(s):  
Political Culture ◽  
Educational System ◽  
Strict Sense ◽  
Political Analysis ◽  
Starting Point ◽  
Political Project ◽  
Systemic Degradation

A political analysis of the Ukrainian state project is being carried out. The idea of state insufficiency of modern Ukraine stands out as the starting point. The analysis shows that for a quarter of a century Ukraine has not been able to overcome any of the crisis stages: identity, penetration, legality, participation and distribution, and in the strict sense has not acquired the obligatory signs of statehood. The authors trace the dynamics of the socioeconomic and humanitarianpolitical problems of an irreversible character or, otherwise, systemic degradation of the society. They point out to the shadowing of the economy, deindustrialization of the country, the demographic collapse, the crisis of the educational system, total corruption, formation of a carnival political culture and moral degradation.

scholarly journals Effects of 5-Fluorodeoxyuridine and Related Halogenated Pyrimidines on the Sand-Dollar Embryo

1960 ◽  
Vol 7 (1) ◽  
pp. 61-71 ◽  
Author(s):  
David A. Karnofsky ◽  
Ross S. Basch
Keyword(s):  
Embryonic Development ◽  
Random Pattern ◽  
Protective Agent ◽  
Sand Dollar ◽  
Blastula Stage ◽  
Bacterial Dna ◽  
Fluorinated Pyrimidines ◽  
Minimal Lethal Concentration ◽  
Embryonic Death

The embryo of the sand-dollar (Echinarachnius parma) was exposed to various concentrations of fluorinated pyrimidines immediately after fertilization. FUDR (5-fluorodeoxyuridine) was most active, and a concentration of 2 to 4 mγ/10 cc. (0.8 to 1.6 x 10-6 m.eq./liter) blocked development at the early blastula stage. Larger doses interrupted development at the same stage. This effect was prevented by thymidine (TDR) and thymine (T); and these pyrimidines protected against many times the minimal lethal concentration of FUDR. TDR was active as a protective agent if added just before early blastula formation. The other fluorinated pyrimidines, 5-fluorouracil (FU), 5-fluorouridine (FUR), 5-fluorocytidine (FCR), 5-fluorodeoxycytidine (FCDR), and 5-fluoroorotic acid (FO), were also studied. These drugs produced effects on embryonic development similar to those seen with FUDR. The effective concentrations, however, varied greatly. T and TDR provided protection against these drugs, but in most cases they were not so effective as against FUDR. 5-Bromodeoxyurdine (BrUDR), beginning at the early blastula stage, caused a random pattern of embryonic death up to the pluteus stage. This drug has been shown to be incorporated into bacterial DNA. BrUDR protected embryos against the early lethal effects of FUDR presumably acting as a thymidine substitute, but the embryos died subsequently in a pattern similar to that seen with BrUDR alone. FUDR and BrUDR appear to inhibit the formation and alter the structure of DNA, respectively, distinctive effects whch may provide a means for studying the role of DNA in embryonic development.

scholarly journals PROSPEK TEKNOLOGI REMEDIASI LAHAN KRITIS DENGAN ASAM HUMAT (Humic Acid)

2016 ◽  
Vol 12 (1) ◽  
pp. 55
Author(s):  
Untung Suwahyono
Keyword(s):  
Soil Structure ◽  
Agricultural Land ◽  
Green Revolution ◽  
Impact Resistance ◽  
Systemic Impact ◽  
Contamination Levels ◽  
The 19Th Century ◽  
Met Expectations ◽  
The Impact ◽  
Systemic Degradation

The green revolution in the 19th century, has met expectations in an effort to increase the productivity of food supply, in the world at least in Indonesia. In the course of time the green revolution movement has given the systemic impact not only on the degradation of ecosystems, but also the productivity of land, especially paddy fields due to the use of agrochemicals that have been over threshold. The impact on soil in Indonesia become ill, there is a change of soil structure, become poorer and finally lost as the land carrying capacity of production. Systemic Degradation covering 18 000 ha of wetland, contamination levels of heavy metals such as Hg, Fe, Cd, Cu has been on conditions that endanger human health also pesticide has an impact resistance to pests.Recovery efforts of agricultural land, will take time, and cost is not cheap. Various studies have been done, to remediation land by using acid-humic substances, and gives results quite encouraging, because it’s quite effective, efficient and inexpensive, compared with conventional methods is to provide an organic material such as kompost.

Characterization of resistance to amethopterin, 8-azaguanine and several fluorinated pyrimidines in the murine lymphocytic neoplasm, P388

1962 ◽  
Vol 60 (2) ◽  
pp. 109-126 ◽  
Author(s):  
Robert A. Roosa ◽  
T. Ray Bradley ◽  
Lloyd W. Law ◽  
Leonard A. Herzenberg
Keyword(s):  
Fluorinated Pyrimidines
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