EMERGING GAMUT OF CARDIOVASCULAR NANOMEDICINE: FUTURE IS BRIGHT

The aim of cardiovascular nanomedicine- CVN is to reduce off-target toxicity issues with therapeutic selectivity to the heart .The lipophilic barrier of the cellular membranes should be circumvented to deliver cargo inside the cell. Lipidbased NPs, which show low side effects and greater ability to passively accumulate at tissues with higher vascular permeability (enhanced permeation rate), have been largely used since the earlier times of cardiovascular nanomedicine-CVN. Polymeric NPs, silica NPs, carbon nanotubes, polymeric micelles, quantum dots, nanobers and nanocrystals represent other examples of nano-formulations for controlled drug delivery. NP-loaded drugs are expected to be protected from systemic degradation, show reduced toxicity and immunogenicity, possess ameliorated pharmacokinetics and increased half-life and exhibit increased bioavailability and precise bio distribution. Nanodrug formulations are expected to enhance selective delivery to the site of interest and benet from a lower clearance from the body. Nanotechnology represents a convergent discipline in which the margins separating research areas, such as chemistry, biology, physics, mathematics and engineering become blurred with the much needed emergence of integrated science as a new discipline.

Manifestations of traditional knowledge in water systems: The cases of the Kuchaman Fort and Rathi Haveli, Rajasthan

Water scarcity in the arid region of Rajasthan incentivized a sophisticated indigenous knowledge of water systems. This traditional knowledge, which was rooted in this geographical context, supported the prosperity of this region for centuries. The systemic degradation of this knowledge has increased the demand for external resources, leading to a constant need for expanding infrastructure. It is therefore time to look back to this traditional wisdom in search of sustainable alternatives. This study focuses on traditional water conservation systems in the purview of the spatial planning and the architectural elements in the Fort and the Rathi Haveli of Kuchaman, Rajasthan. These two traditional complexes have been studied for the interest and similarities found in the way they manage their water resources. This study highlights the timeless simplicity of the identified indigenous strategies and envisions possible manifestations of this knowledge for contemporary practice.

A Struggle for Dignity: The Kalavanteens of Maharashtra

Thrice alienated, Dalit women face a triple burden of caste, class and gender. The subaltern women belonging to Dalit communities in Kolhapur, Maharashtra is the focus of my paper. I have conducted in-depth interviews of the women I have met; and carefully documented their lives over a period of years. In due course of time, I realized that there are kalavanteen women (artistes of various folk-art forms) who are struggling to leave behind a tainted life and seize the opportunity to live a life of dignity. These are women who are involved in the performing arts, including singing, dancing and acting; Lavani, Tamasha and Jalsas. Such women who performed and entertained were available for sexual pleasures, but rarely married. They were rarely considered honourable women. Now when the image is that of a performing woman, she too will be consumed with greedy/hungry eyes. Her body parts too, are exposed to male glances, she has to attract them, as such, she cannot be expected to be chaste. However, in Kolhapur today, these kalavanteen, women have challenged their Dalitness; contested their being downtrodden; and finally derived a sense of agency from their being Dalit, their being downtrodden. I felt that it is highly significant to trace the manner in which they have attacked the systemic degradation that has eroded their lives for decades and tried to bring a sense of dignity.

UKRAINIAN POLITICAL PROJECT: FROM GOVERNMENT INSUFFICIENCY TO SOCIAL DEGRADATION

A political analysis of the Ukrainian state project is being carried out. The idea of state insufficiency of modern Ukraine stands out as the starting point. The analysis shows that for a quarter of a century Ukraine has not been able to overcome any of the crisis stages: identity, penetration, legality, participation and distribution, and in the strict sense has not acquired the obligatory signs of statehood. The authors trace the dynamics of the socioeconomic and humanitarianpolitical problems of an irreversible character or, otherwise, systemic degradation of the society. They point out to the shadowing of the economy, deindustrialization of the country, the demographic collapse, the crisis of the educational system, total corruption, formation of a carnival political culture and moral degradation.

Cинтез и испытания 1 m-=SUP=-3-=/SUP=- жидкого сцинтиллятора на основе линейного алкилбензола

The stability of a liquid organic scintillator based on linear alkylbenzene in a volume of 1 m^3 was measured. The measurements were performed using an iDREAM reactor antineutrino detector at the National Research Center Kurchatov Institute. No systemic degradation of the scintillator light yield within an observation time of 225 days was observed. These long-term stability measurements of a large-volume liquid organic scintillator based on linear alkylbenzene are the first in Russia.

PROSPEK TEKNOLOGI REMEDIASI LAHAN KRITIS DENGAN ASAM HUMAT (Humic Acid)

The green revolution in the 19th century, has met expectations in an effort to increase the productivity of food supply, in the world at least in Indonesia. In the course of time the green revolution movement has given the systemic impact not only on the degradation of ecosystems, but also the productivity of land, especially paddy fields due to the use of agrochemicals that have been over threshold. The impact on soil in Indonesia become ill, there is a change of soil structure, become poorer and finally lost as the land carrying capacity of production. Systemic Degradation covering 18 000 ha of wetland, contamination levels of heavy metals such as Hg, Fe, Cd, Cu has been on conditions that endanger human health also pesticide has an impact resistance to pests.Recovery efforts of agricultural land, will take time, and cost is not cheap. Various studies have been done, to remediation land by using acid-humic substances, and gives results quite encouraging, because it’s quite effective, efficient and inexpensive, compared with conventional methods is to provide an organic material such as kompost.

DOMESTIC VIOLENCE ON WOMAN: A SOCIOLOGICAL ANALYSIS

Violence against women is one of the old paradoxes of Indian Society. Contradictory statements about glorifying and condemning women are found in abundant measure. In Indian society, we talk about equality, dignity and respect for women, and goes to the extent of saying that “Gods reside where women are worshipped” at the practical operational level the society. However, follows practices that are quite contrary to its preaching’s. In one go the society considers women, as goddesses and in another go as slaves, but never as human beings with dignity and self-respect. The rhetoric apart, dual standards for men and women have paved the way for gradual deterioration of women’s position. Systemic degradation, inferiority and sub ordination is thus, an old theme of ancient vintage (Social Welfare: 2008).