Experience with the use of palivizumab together with infection control measures to prevent respiratory syncytial virus outbreaks in neonatal intensive care units

2008 ◽  
Vol 70 (3) ◽  
pp. 246-252 ◽  
Author(s):  
H. Kurz ◽  
K. Herbich ◽  
O. Janata ◽  
W. Sterniste ◽  
K. Bauer
Keyword(s):  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Infection Control ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Neonatal Intensive Care Units ◽  
Infection Control Measures ◽  
Syncytial Virus

scholarly journals Multiple Respiratory Syncytial Virus Introductions Into a Neonatal Intensive Care Unit

2020 ◽  
Author(s):  
Erica Billig Rose ◽  
Erica J Washington ◽  
Lijuan Wang ◽  
Isaac Benowitz ◽  
Natalie J Thornburg ◽  
...  
Keyword(s):  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Infection Control ◽  
Respiratory Symptoms ◽  
Phylogenetic Trees ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Infection Control Measures ◽  
Young Infants ◽  
Syncytial Virus

Abstract Background Outbreaks of respiratory syncytial virus (RSV) in neonatal intensive care units (NICUs) are of concern because of the risk of severe disease in young infants. We describe an outbreak of RSV in a NICU and use whole genome sequencing (WGS) to better understand the relatedness of viruses among patients. Methods An investigation was conducted to identify patients and describe their clinical course. Infection control measures were implemented to prevent further spread. Respiratory specimens from outbreak-related patients and the community were tested using WGS. Phylogenetic trees were constructed to understand relatedness of the viruses. Results Seven patients developed respiratory symptoms within an 11-day span in December 2017 and were diagnosed with RSV; 6 patients (86%) were preterm and 1 had chronic lung disease. Three patients required additional respiratory support after symptom onset, and none died. Six of 7 patients were part of the same cluster based on > 99.99% nucleotide agreement with each other and 3 unique single-nucleotide polymorphisms were identified in viruses sequenced from those patients. The seventh patient was admitted from the community with respiratory symptoms and had a genetically distinct virus that was not related to the other 6. Implementation of enhanced infection control measures likely limited the spread. Conclusions Using WGS, we found 2 distinct introductions of RSV into a NICU, highlighting the risk of healthcare-associated infections during RSV season. Early recognition and infection control measures likely limited spread, emphasizing the importance of considering RSV in the differential diagnosis of respiratory infections in healthcare settings.

scholarly journals Effect of camera monitoring and feedback along with training on hospital infection rate in a neonatal intensive care unit

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Meltem Karabay ◽  
Gulsum Kaya ◽  
Taner Hafizoglu ◽  
Oguz Karabay
Keyword(s):  
Health Care ◽  
Intensive Care ◽  
Infection Control ◽  
Health Care Workers ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Occurrence Rate ◽  
Infection Control Measures ◽  
Care Workers ◽  
Healthcare Associated

Abstract Background In terms of pediatric healthcare-associated infections (HAI), neonatal intensive care units (NICU) constitute the greatest risk. Contacting a health care personnel, either directly or indirectly, elevates NICU occurrence rate and risks other infants in the same unit. In this study, it is aimed to retrospectively analyze the effect of the training along with camera monitoring and feedback (CMAF) to control the infection following a small outbreak. Methods ESBL producing Klebsiella pneumoniae was detected on three infants in May 2014 at the isolation room of Sakarya University Hospital NICU. Precautions were taken to prevent further spread of the infection. The infected infants were isolated and the decolonization process was initiated. For this aspect, health care workers (HCWs) in NICU were trained for infection control measures. An infection control committee has monitored the HCWs. Before monitoring, an approval was obtained from the hospital management and HCWs were informed about the CMAF, who were then periodically updated. On a weekly basis, NICU workers were provided with the feedbacks. Epidemic period and post-epidemic control period (June–July–August 2014) were evaluated and p value < 0.05 was considered statistically significant. Results Healthcare-associated infection (HAI) density was 9.59% before the onset of the CMAF, whereas it was detected as 2.24% during the CMAF period (p < 0.05). Following the precautions, HAI and HAI density rates have reduced to 76.6% and 74.85%, respectively. Moreover, hand hygiene compliance of health care workers was found 49.0% before the outbreak, whereas this rate has elevated to 62.7% after CMAF. Conclusions Healthcare workers should be monitored in order to increase their compliance for infection control measures. Here, we emphasized that that CMAF of health workers may contribute reducing the HAI rate in the NICU.

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