Use of palivizumab and infection control measures to control an outbreak of respiratory syncytial virus in a neonatal intensive care unit confirmed by real-time polymerase chain reaction

2011 ◽  
Vol 77 (4) ◽  
pp. 338-342 ◽  
Author(s):  
K. O’Connell ◽  
T.W. Boo ◽  
D. Keady ◽  
U. NiRiain ◽  
D. O’Donovan ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Polymerase Chain Reaction ◽  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Chain Reaction ◽  
Infection Control Measures ◽  
Polymerase Chain ◽  
Syncytial Virus

scholarly journals Multiple Respiratory Syncytial Virus Introductions Into a Neonatal Intensive Care Unit

2020 ◽  
Author(s):  
Erica Billig Rose ◽  
Erica J Washington ◽  
Lijuan Wang ◽  
Isaac Benowitz ◽  
Natalie J Thornburg ◽  
...  
Keyword(s):  
Intensive Care ◽  
Respiratory Syncytial Virus ◽  
Infection Control ◽  
Respiratory Symptoms ◽  
Phylogenetic Trees ◽  
Neonatal Intensive Care ◽  
Control Measures ◽  
Infection Control Measures ◽  
Young Infants ◽  
Syncytial Virus

Abstract Background Outbreaks of respiratory syncytial virus (RSV) in neonatal intensive care units (NICUs) are of concern because of the risk of severe disease in young infants. We describe an outbreak of RSV in a NICU and use whole genome sequencing (WGS) to better understand the relatedness of viruses among patients. Methods An investigation was conducted to identify patients and describe their clinical course. Infection control measures were implemented to prevent further spread. Respiratory specimens from outbreak-related patients and the community were tested using WGS. Phylogenetic trees were constructed to understand relatedness of the viruses. Results Seven patients developed respiratory symptoms within an 11-day span in December 2017 and were diagnosed with RSV; 6 patients (86%) were preterm and 1 had chronic lung disease. Three patients required additional respiratory support after symptom onset, and none died. Six of 7 patients were part of the same cluster based on > 99.99% nucleotide agreement with each other and 3 unique single-nucleotide polymorphisms were identified in viruses sequenced from those patients. The seventh patient was admitted from the community with respiratory symptoms and had a genetically distinct virus that was not related to the other 6. Implementation of enhanced infection control measures likely limited the spread. Conclusions Using WGS, we found 2 distinct introductions of RSV into a NICU, highlighting the risk of healthcare-associated infections during RSV season. Early recognition and infection control measures likely limited spread, emphasizing the importance of considering RSV in the differential diagnosis of respiratory infections in healthcare settings.

scholarly journals Gambaran Klinis dan Karakteristik Neonatus dari Ibu Terkonfimasi Covid-2019 di Rumah Sakit Dr. Soetomo

Sari Pediatri ◽  
2021 ◽  
Vol 22 (5) ◽  
pp. 285
Author(s):  
Risa Etika ◽  
Kartika Darma Handayani ◽  
Setya Mithra Hartiastuti ◽  
Virani Diana ◽  
Aminuddin Harahap ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Polymerase Chain Reaction ◽  
Intensive Care ◽  
Severe Acute Respiratory Syndrome ◽  
Neonatal Intensive Care Unit ◽  
Reverse Transcription ◽  
Neonatal Intensive Care ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Polymerase Chain

Latar belakang. Penyakit Coronavirus 2019 (COVID-19) merupakan penyakit yang pertama kali dilaporkan di Wuhan, China dan telah menyebar ke seluruh dunia. Data ibu hamil dan bayi baru lahir belum banyak dipublikasikan.Tujuan. Untuk mendeskripsikan gambaran dan karakteristik klinis neonatus yang lahir dari ibu dengan infeksi severe acute respiratory syndrome-coronavirus (SARS-CoV-2) perinatal.Metode. Penelitian ini merupakan penelitian retrospektif yang dilaksanakan di ruang perawatan neonatal intensive care unit (NICU) Rumah Sakit Umum Daerah Dr.Soetomo Surabaya pada tanggal April - Oktober 2020. Populasi adalah neonatus yang lahir dari ibu terkonfimasi COVID-19 di di Rumah Sakit Dr. Soetomo Surabaya. Data diperoleh dari rekam medik.Hasil. Total terdapat 109 ibu dengan hasil pemeriksaan positif reverse transcription - polymerase chain reaction (RT PCR) COVID-19, dan hanya 2 bayi dengan hasil RT-PCR COVID-19 positif. Usia rata-rata ibu hamil 28±5,9 tahun. Duapuluh sembilan bayi (26,61%) lahir kurang bulan. Cara persalinan didominasi oleh sectio caesaria sebanyak 64 ibu hamil (58,72%). Terdapat 23 bayi (21,11%) lahir dengan berat badan lahir <2500 gram dan 3 bayi dengan hasil negatif RT-PCR COVID-19 meninggal.Kesimpulan. Saat ini belum terbukti adanya penularan secara vertikal COVID 19, sementara itu transmisi horizontal diperkirakan sebagai sumber infeksi pada neonatus. Penerapan protokol kesehatan terbukti efektif mencegah infeksi terhadap neonatus. 

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