The Analgesic Effect of Paeoniflorin on Neonatal Maternal Separation–Induced Visceral Hyperalgesia in Rats

2008 ◽  
Vol 9 (6) ◽  
pp. 497-505 ◽  
Author(s):  
Xiao-jun Zhang ◽  
Zhi Li ◽  
Wai-mui Leung ◽  
Liang Liu ◽  
Hong-xi Xu ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Maternal Separation ◽  
Visceral Hyperalgesia ◽  
Neonatal Maternal Separation

Neonatal maternal separation results in stress-induced visceral hyperalgesia in adult rats: A new model for IBS

2000 ◽  
Vol 118 (4) ◽  
pp. A637 ◽  
Author(s):  
Santosh V. Coutinho ◽  
Marciano R. Sablad ◽  
Jerry C. Miller ◽  
Huping Zhou ◽  
Alan Lam ◽  
...  
Keyword(s):  
Maternal Separation ◽  
Visceral Hyperalgesia ◽  
Adult Rats ◽  
New Model ◽  
Neonatal Maternal Separation ◽  
Separation Results

Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat

2002 ◽  
Vol 282 (2) ◽  
pp. G307-G316 ◽  
Author(s):  
S. V. Coutinho ◽  
P. M. Plotsky ◽  
M. Sablad ◽  
J. C. Miller ◽  
H. Zhou ◽  
...  
Keyword(s):  
Maternal Separation ◽  
Colonic Motility ◽  
Tail Flick ◽  
Visceral Hyperalgesia ◽  
Adult Rats ◽  
Tail Flick Test ◽  
Neonatal Maternal Separation ◽  
Long Evans ◽  
Irritable Bowel ◽  
Psychological Stressor

This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long-Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) on postnatal days 2–14 or 2) no handling or separation (NH). At 2 mo of age, visceromotor responses to graded intensities of phasic colorectal distension (10–80 mmHg) at baseline as well as following acute 60 min water avoidance stress (WA) were significantly higher in MS180 rats. Both groups showed similar stress-induced visceral hyperalgesia in the presence of naloxone (20 mg/kg ip). MS180 rats had smaller stress-induced cutaneous analgesia in the tail-flick test compared with NH rats, with a residual naloxone-resistant component. MS180 rats showed an enhanced fecal pellet output following WA or exposure to a novel environment. These data suggest that early life events predispose adult Long-Evans rats to develop visceral hyperalgesia, reduced somatic analgesia, and increased colonic motility in response to an acute psychological stressor, mimicking the cardinal features of irritable bowel syndrome.

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