A novel dehydroabietic acid-based AIE-active fluorescent probe for rapid detection of Hg2+ and its environmental and biological applications

2021 ◽  
pp. 113597
Author(s):  
Qing-song Liu ◽  
Zi-hui Yang ◽  
Zhong-long Wang ◽  
Yue Sun ◽  
Lin-lin Chen ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rapid Detection ◽  
Dehydroabietic Acid ◽  
Biological Applications

The recent advance of organic fluorescent probe rapid detection for common substances in beverages

2021 ◽  
pp. 129839
Author(s):  
Ning Duan ◽  
Shaoxiang Yang ◽  
Hongyu Tian ◽  
Baoguo Sun
Keyword(s):  
Fluorescent Probe ◽  
Rapid Detection

FLGS-01. Development of novel topical fluorescent probe for intraoperative rapid detection of glioma

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi225-vi226
Author(s):  
Shota Tanaka ◽  
Yosuke Kitagawa ◽  
Mako Kamiya ◽  
Takenori Shimizu ◽  
Yasuteru Urano ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Fluorescent Probe ◽  
Rapid Detection ◽  
Aminolevulinic Acid ◽  
Characteristic Curve ◽  
Screening Method ◽  
Tumor Resection ◽  
Phase Iii ◽  
Glioma Surgery ◽  
Two Dimensional Gel Electrophoresis

Abstract PURPOSE Fluorescence imaging is an important surgical adjunct in malignant glioma surgery. 5-aminolevulinic acid (5-ALA) has been proven effective for radical tumor resection and extended progression-free survival in a phase III randomized trial and therefore integrated into surgery for malignant glioma. Importantly, however, some limitations still exist in its use, which include false positivity and false negativity as well as inability of re-administration. In this study, we aimed to develop a novel, spray-type fluorescent probe using hydroxymethyl rhodamine green (HMRG) as a fluorescent scaffold. METHODS We have previously established a fluorescent probe library comprised of more than 320 kinds of HMRG probes. They have HMRG as a fluorescent scaffold with various types of dipeptides attached to it. Primary probe screening was performed using the homogenized tumor samples from patients with glioblastoma operated at our institution. Secondary screening followed using the selected probes and fresh tumor samples obtained from patients with glioblastoma operated from 2016 until 2018. Diced electrophoresis gel (DEG) assay, two-dimensional gel electrophoresis followed by a multi-well plate-based fluorometric assay, was performed to identify responsible enzymes for the selected probe. Further experiments with inhibitors, real-time PCR, immunohistochemistry, and western blotting were performed for confirmation. RESULTS Proline-arginine-HMRG (PR-HMRG) was selected as a candidate probe based upon the above two-step screenings. It achieved 79.4% accuracy in receiver operating characteristic curve analysis. Calpain-1 was found to be responsible to cleave PR-HMRG probe by DEG-proteome analysis. Calpain-1 protein was highly expressed in tumor tissues which reacted to PR-HMRG probe. CONCLUSIONS Our innovative screening method was able to find PR-HMRG as a novel fluorescent probe effective for rapid detection of glioblastoma. A preclinical study is planned to assess the efficacy and safety of the selected probe.

A dual-emission and mitochondria-targeted fluorescent probe for rapid detection of SO2 derivatives and its imaging in living cells

Talanta ◽  
2019 ◽  
Vol 191 ◽  
pp. 428-434 ◽  
Author(s):  
Guoxing Yin ◽  
Yabing Gan ◽  
Ting Yu ◽  
Tingting Niu ◽  
Peng Yin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rapid Detection ◽  
Living Cells ◽  
Dual Emission

A fluorescent probe for rapid detection of estrogen receptors

Cancer ◽  
1980 ◽  
Vol 46 (S12) ◽  
pp. 2902-2906 ◽  
Author(s):  
B. Ramanath Rao ◽  
C. Glenn Fry ◽  
Steven Hunt ◽  
Radka Kuhnel ◽  
Walter B. Dandliker
Keyword(s):  
Estrogen Receptors ◽  
Fluorescent Probe ◽  
Rapid Detection

A multiple-detection-point fluorescent probe for the rapid detection of mercury(II), hydrazine and hydrogen sulphide

2020 ◽  
Vol 174 ◽  
pp. 108056 ◽  
Author(s):  
Xiaoming Wu ◽  
Yanan Li ◽  
Shaoxiang Yang ◽  
Hongyu Tian ◽  
Baoguo Sun
Keyword(s):  
Fluorescent Probe ◽  
Hydrogen Sulphide ◽  
Rapid Detection ◽  
Detection Point ◽  
Multiple Detection

Nopinone-based AIE-active dual-functional fluorescent chemosensor for Hg2+ and Cu2+ and its environmental and biological applications

2020 ◽  
Vol 49 (43) ◽  
pp. 15299-15309
Author(s):  
Mingxin Li ◽  
Shutang Ruan ◽  
Haiyan Yang ◽  
Yan Zhang ◽  
Yiqin Yang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Environmental Analysis ◽  
Fluorescent Chemosensor ◽  
Biological Applications ◽  
Dual Functional

A nopinone-based dual-functional fluorescent probe for Hg2+ and Cu2+ and its applications in environmental analysis and bioimaging.

scholarly journals Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

RSC Advances ◽  
2020 ◽  
Vol 10 (23) ◽  
pp. 13496-13499 ◽  
Author(s):  
Luling Wu ◽  
Xue Tian ◽  
Robin R. Groleau ◽  
Jie Wang ◽  
Hai-Hao Han ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Rapid Detection ◽  
Simultaneous Detection

A coumarin-based novel ‘AND’ logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO− and biological thiols.

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