A comprehensive analysis of transcriptome and phenolic compound profiles suggests the role of flavonoids in cotyledon greening in Catharanthus roseus seedling

2021 ◽  
Author(s):  
Bofan Yu ◽  
Yajie Pan ◽  
Yang Liu ◽  
Qi Chen ◽  
Xiaorui Guo ◽  
...  
Keyword(s):  
Phenolic Compound ◽  
Catharanthus Roseus ◽  
Comprehensive Analysis ◽  
Cotyledon Greening

scholarly journals Past and future trends of Egypt’s water consumption and its sources

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Catherine A. Nikiel ◽  
Elfatih A. B. Eltahir
Keyword(s):  
Economic Growth ◽  
Virtual Water ◽  
Comprehensive Analysis ◽  
Future Trends ◽  
Nile Water ◽  
The Gift ◽  
Per Capita ◽  
The 1960S

AbstractFor millennia the Nile supplied Egypt with more water than needed. As the population grew and the economy expanded, demand on water increased accordingly. Here, we present a comprehensive analysis to reconstruct how total demand on water outstripped supply of the Nile water in the late 1970s, starting from a surplus of about 20 km3 per year in the 1960s leading to a deficit of about 40 km3 per year by the late 2010s. The gap is satisfied by import of virtual water. The role of economic growth in driving per capita demand on water is quantified based on detailed analysis of water use by agriculture and other sectors. We develop and test an empirical model of water demand in Egypt that relates demand on water to growth rates in the economy and population. Looking forward, we project that within this decade of the 2020 s, under nominal scenarios of population and economic growth, Egypt is likely to import more virtual water than the water supplied by the Nile, bringing into question the historical characterization of Egypt as “the gift of the Nile”.

scholarly journals Glioma Revisited: From Neurogenesis and Cancer Stem Cells to the Epigenetic Regulation of the Niche

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Felipe de Almeida Sassi ◽  
Algemir Lunardi Brunetto ◽  
Gilberto Schwartsmann ◽  
Rafael Roesler ◽  
Ana Lucia Abujamra
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Cellular Proliferation ◽  
Survival Rates ◽  
Comprehensive Analysis ◽  
Heterogeneous Population ◽  
Aggressive Tumor ◽  
Epigenetic Modulation ◽  
The Brain

Gliomas are the most incident brain tumor in adults. This malignancy has very low survival rates, even when combining radio- and chemotherapy. Among the gliomas, glioblastoma multiforme (GBM) is the most common and aggressive type, and patients frequently relapse or become refractory to conventional therapies. The fact that such an aggressive tumor can arise in such a carefully orchestrated organ, where cellular proliferation is barely needed to maintain its function, is a question that has intrigued scientists until very recently, when the discovery of the existence of proliferative cells in the brain overcame such challenges. Even so, the precise origin of gliomas still remains elusive. Thanks to new advents in molecular biology, researchers have been able to depict the first steps of glioma formation and to accumulate knowledge about how neural stem cells and its progenitors become gliomas. Indeed, GBM are composed of a very heterogeneous population of cells, which exhibit a plethora of tumorigenic properties, supporting the presence of cancer stem cells (CSCs) in these tumors. This paper provides a comprehensive analysis of how gliomas initiate and progress, taking into account the role of epigenetic modulation in the crosstalk of cancer cells with their environment.

scholarly journals On Stereocontrol in Organocatalytic α-Chlorinations of Aldehydes

2021 ◽  
Author(s):  
Sebastian Ponath ◽  
Chetan Joshi ◽  
Amy T. Merrill ◽  
Volker Schmidts ◽  
Kim Greis ◽  
...  
Keyword(s):  
Ion Mobility ◽  
Resting State ◽  
Comprehensive Analysis ◽  
Ion Mobility Mass Spectrometry ◽  
Concentration Profiles ◽  
Nmr Studies ◽  
Isotope Studies ◽  
Configuration And Conformation

A comprehensive analysis of the organocatalytic α‐chlorination of aldehydes with N‐chloroimides and differ‐ ent catalysts is presented. For this reaction, alternate mechanisms were proposed that differ in the role of resting state intermediates and the rationalization of the observed enantioselectivity. This manuscript aims at resolving these funda‐ mental questions on the basis of rigorous structural characterization of intermediates (configuration and conformation), NMR studies, ion mobility‐mass spectrometry, concentration profiles, isotope studies, and DFT calculations. <br>

scholarly journals DEVELOPMENT OF PHILOSOPHICAL AND METHODOLOGICAL CULTURE OF FUTURE DOCTORS OF PHILOSOPHY

2021 ◽  
pp. 299-308
Author(s):  
Anatolіі Berzhanir
Keyword(s):  
Social Activity ◽  
Comprehensive Analysis ◽  
Specific Form ◽  
Theoretical Concepts ◽  
Philosophical Foundations ◽  
Philosophical Interpretation ◽  
Methodological Approaches ◽  
Creativity And Innovation ◽  
Methodological Component

The article shows the relevance of the development of the philosophical and methodological culture of future doctors of philosophy in the context of cardinal changes in the domestic system of higher education. It is indicated that the actualization of the acquisition of knowledge, skills and abilities of the philosophical foundations of understanding methodological approaches in scientific research provides an increase in the level of scientific and pedagogical activity of teachers. A philosophical interpretation of the essence of methodological culture has been carried out. It has been determined that the fundamental basis for the development of a philosophical and methodological culture is the applicants’ understanding of the essence of science as a social phenomenon and a specific form of social activity. The formation of the methodological culture among future doctors of philosophy presupposes their possession of the system of pedagogical scientific competencies. The main elements that make up the structure of the philosophical and methodological culture, which include professional, axiological, cognitive, communicative activities, have been substantiated. The role of the philosophical and methodological component is established, which affects the formation of the dialectical style of thinking and provides for a comprehensive analysis of the philosophical essence of the content of theoretical concepts. The role of creativity and innovation in the process of the formation of the teacher's personality has been investigated. The system of pedagogical competencies as a result of the formation of methodological culture is characterized. The criteria for the formation of the philosophical and methodological culture of future doctors of philosophy have been determined.

scholarly journals Administrative and Legal Principles of the Activities of the National Police of Ukraine in Preventing and Counteracting Bullying

2020 ◽  
Vol 79 (4) ◽  
pp. 48-53
Author(s):  
Д. А. Сорочан
Keyword(s):  
Comprehensive Analysis ◽  
Educational Institutions ◽  
Main Task ◽  
Legal Principles ◽  
Ethical Education ◽  
Preventive Activity ◽  
Close Cooperation ◽  
National Police ◽  
The Impact

The negative socio-economic situation and large gaps in the moral and ethical education of the younger generation have led to an increase in the number of cases of deliberate abuse of older and stronger to the smaller and weaker members of educational institutions. The author has studied administrative and legal principles of the activity of the National Police of Ukraine on preventing and counteracting bullying. Based on a comprehensive analysis of national legislation on preventing and combating bullying in Ukraine, the author has determined perspective areas for improving administrative and legal principles in this area. It has been emphasized that the role of the National Police in this area cannot be limited to the preventive registration of a child. It is necessary to develop a set of preventive and educational measures aimed at preventing bullying manifestations among minors. It has been found out that there are no tools to assess the effectiveness of the impact of existing strategies to combat bullying in Ukraine, which necessitates further research in this area. It has been determined that it is necessary to fight not with individual facts of bullying, but to enshrine in the legislation the system of counteraction to harassment in educational institutions, which can be preventive in nature. It has been established that the legislator has introduced a number of amendments over the last few years, which are characterized by the strengthening of the component of protection of children’s rights. A positive novelty is that the main task of the juvenile police was preventive activity instead of punitive one. In general, the regulatory basis for the activities of the National Police of Ukraine to prevent and combat bullying can be divided into two parts: general legislative acts and departmental regulatory acts. It has been noted that the prevention of bullying and the prevention and combating of domestic violence are different aspects of the same problem, which are in constant close cooperation, and then the measures to overcome them should be common.

scholarly journals “It is not a miracle, but grief...”: representations of Sergey Kozlov's on soteriological mission of the woman (based on the novella “Mother-Masha”)

2021 ◽  
pp. 46-52
Author(s):  
Alena Petrovna Kashkareva
Keyword(s):  
Comprehensive Analysis ◽  
Russian Philosophy ◽  
Russian History ◽  
Female Images ◽  
Textual Space ◽  
The World ◽  
National Salvation

This article analyzes the views of the contemporary Ugric writer Sergey Kozlov pertaining to mission of the women in 1990s &ndash; 2000s, which was the turning period for the country. The novella &ldquo;Mother-Masha&rdquo; demonstrates that it textual space, namely the woman becomes the symbol of justice of the Christian fabric of life, and is reflected in the sincere desire of the protagonist to establish good and justice in the world. The author contemplates on S. Kozlov's ideological and artistic views upon the role of the woman at the time of major transformations in the Russian history. Reference to the writer&rsquo;s fictional prose, diaries, and interviews allows revealing the peculiarities of his axiological position in the context of the Russian philosophy of femininity. The scientific novelty of this research is substantiated by the need for articulation of the problem related to the study of specificity of female images in the creative heritage of Siberian writer Sergey Kozlov. Comprehensive analysis of the writer's novella &ldquo;Mother-Masha&rdquo; included into the book &ldquo;Duty Angel&rdquo; (2011) is carried out. The article introduces the sources, such as diary notes and interview materials, which have not been previously used in studying the works of S. Kozlov. The conclusion is made that soteriological mission was imposed on Mother Masha &ndash; the woman who proliferated the Divine Commandments to the world and is associated with the symbol of national salvation.

scholarly journals The Pre-Deal Phase of Mergers and Acquisitions: A Review and Research Agenda

2019 ◽  
Vol 46 (6) ◽  
pp. 843-878 ◽  
Author(s):  
Xena Welch ◽  
Stevo Pavićević ◽  
Thomas Keil ◽  
Tomi Laamanen
Keyword(s):  
Mergers And Acquisitions ◽  
Research Agenda ◽  
Temporal Dynamics ◽  
Target Selection ◽  
Comprehensive Analysis ◽  
Research Interest ◽  
Theoretical Base ◽  
Topic Area ◽  
High Level

Despite the long-standing research interest in the pre-deal phase of mergers and acquisitions, many important questions remain unanswered. We review and synthesize the extensive but rather fragmented research on this topic area in the fields of management, finance, accounting, and economics. We organize our review according to six themes, that is, deal initiation, target selection, bidding and negotiation, valuation and financing, announcement, and closure, which represent the main categories of activities performed during the pre-deal phase. Our review shows that most of the existing research relies on a rather high-level, simplified, and static conception of the pre-deal phase. On the basis of our review, we put forward a research agenda that calls for a more granular examination of individual activities and decisions, a more comprehensive analysis of the interplay among the different actors involved in the pre-deal phase, a better understanding of the role of the temporal dynamics, and the extension of the theoretical base from variance-based to process-based theorizing.

Role of Ca 2+ in phenolic compound metabolism of barley ( Hordeum vulgare L.) sprouts under NaCl stress

2019 ◽  
Vol 99 (11) ◽  
pp. 5176-5186 ◽  
Author(s):  
Yan Ma ◽  
Pei Wang ◽  
Ting Zhou ◽  
Zhijie Chen ◽  
Zhenxin Gu ◽  
...  
Keyword(s):  
Hordeum Vulgare ◽  
Phenolic Compound ◽  
Nacl Stress ◽  
Hordeum Vulgare L

Project MI-Net

2011 ◽  
pp. 70-87
Author(s):  
Pankaj Bagri ◽  
L. S. Murty ◽  
T. R. Madanmohan ◽  
Rajendra K. Bandi
Keyword(s):  
Consumer Goods ◽  
Fast Moving ◽  
Comprehensive Analysis ◽  
It Infrastructure ◽  
Cost Benefits ◽  
Related Data ◽  
Fast Moving Consumer Goods ◽  
Time Basis ◽  
Implementation Stage

This case gives a detailed description of the adoption of an e-business initiative by Miracle Industries Limited (MIL), a fast-moving consumer goods (FMCG) organization in India. The initiative involved linking up with key distributors so as to get important sales-related data on a real-time basis. The case describes how the decision to adopt the project was taken after a comprehensive analysis involving a detailed cost-benefits study, and an examination of the roles of various stakeholders — the distributors and the Territory Sales Officers. It also illustrates how the organization proactively managed the changes introduced by the adoption by communicating extensively about the benefits of the project to the stakeholders, and by providing training and incentives to them. The role of the existing IT infrastructure and unambiguous support from the top management in enabling a smooth rollout is also discussed. Finally, the dissatisfaction of some distributors in the post-implementation stage has been captured.

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