Recent advances in the cell biology of chlorophyll catabolism

2001 ◽  
pp. 1-52 ◽  
Author(s):  
Howard Thomas ◽  
Helen Ougham ◽  
Stefan Hörtensteiner
Keyword(s):  
Cell Biology ◽  
Recent Advances

Recent Advances of Small Molecular Regulators Targeting G Protein- Coupled Receptors Family for Oncology Immunotherapy

2019 ◽  
Vol 19 (16) ◽  
pp. 1464-1483 ◽  
Author(s):  
Peng He ◽  
Wenbo Zhou ◽  
Mingyao Liu ◽  
Yihua Chen
Keyword(s):  
G Protein ◽  
Cell Biology ◽  
Immune Cell ◽  
G Protein Coupled Receptors ◽  
Treatment Modalities ◽  
Immune Checkpoints ◽  
Considerable Proportion ◽  
Prostaglandin E ◽  
Recent Advances ◽  
G Protein Coupled

The great clinical success of chimeric antigen receptor T cell (CAR-T) and PD-1/PDL-1 inhibitor therapies suggests the drawing of a cancer immunotherapy age. However, a considerable proportion of cancer patients currently receive little benefit from these treatment modalities, indicating that multiple immunosuppressive mechanisms exist in the tumor microenvironment. In this review, we mainly discuss recent advances in small molecular regulators targeting G Protein-Coupled Receptors (GPCRs) that are associated with oncology immunomodulation, including chemokine receptors, purinergic receptors, prostaglandin E receptor EP4 and opioid receptors. Moreover, we outline how they affect tumor immunity and neoplasia by regulating immune cell recruitment and modulating tumor stromal cell biology. We also summarize the data from recent clinical advances in small molecular regulators targeting these GPCRs, in combination with immune checkpoints blockers, such as PD-1/PDL-1 and CTLA4 inhibitors, for cancer treatments.

scholarly journals Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

2019 ◽  
Vol 29 (39) ◽  
pp. 1903114 ◽  
Author(s):  
Ali Doryab ◽  
Sinem Tas ◽  
Mehmet Berat Taskin ◽  
Lin Yang ◽  
Anne Hilgendorff ◽  
...  
Keyword(s):  
Cell Biology ◽  
Mechanical Forces ◽  
Recent Advances

scholarly journals Erratum: Recent Advances in Dendritic Cell Biology

2005 ◽  
Vol 25 (3) ◽  
pp. 175-188 ◽  
Author(s):  
Sylvia Adams ◽  
David W. O’Neill ◽  
Nina Bhardwaj
Keyword(s):  
Dendritic Cell ◽  
Cell Biology ◽  
Recent Advances

Recent advances in hematopoietic stem cell biology

2004 ◽  
Vol 11 (6) ◽  
pp. 392-398 ◽  
Author(s):  
Jesper Bonde ◽  
David A Hess ◽  
Jan A Nolta
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Hematopoietic Stem ◽  
Recent Advances

scholarly journals Commensal microbes and p53 in cancer progression

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Ivana Celardo ◽  
Gerry Melino ◽  
Ivano Amelio
Keyword(s):  
Host Cell ◽  
Cancer Progression ◽  
Gut Microbiome ◽  
Cell Biology ◽  
Host Cells ◽  
Intestinal Tumorigenesis ◽  
Recent Advances ◽  
Microenvironmental Factors ◽  
Physiological Pathways

AbstractAetiogenesis of cancer has not been fully determined. Recent advances have clearly defined a role for microenvironmental factors in cancer progression and initiation; in this context, microbiome has recently emerged with a number of reported correlative and causative links implicating alterations of commensal microbes in tumorigenesis. Bacteria appear to have the potential to directly alter physiological pathways of host cells and in specific circumstances, such as the mutation of the tumour suppressive factor p53, they can also directly switch the function of a gene from oncosuppressive to oncogenic. In this minireview, we report a number of examples on how commensal microbes alter the host cell biology, affecting the oncogenic process. We then discuss more in detail how interaction with the gut microbiome can affect the function of p53 mutant in the intestinal tumorigenesis.

scholarly journals Stem cell therapies for acute spinal cord injury in humans: a review

2019 ◽  
Vol 46 (3) ◽  
pp. E10 ◽  
Author(s):  
Michael C. Jin ◽  
Zachary A. Medress ◽  
Tej D. Azad ◽  
Vanessa M. Doulames ◽  
Anand Veeravagu
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Biology ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Recent Advances ◽  
Cord Injury

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translation efforts, including combinatorial strategies utilizing scaffolds, biogels, and growth factors to augment stem cell survival, function, and engraftment. Finally, the authors discuss the evolution of stem cell therapies for SCI by providing an overview of completed (n = 18) and ongoing (n = 9) clinical trials.

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