Towards adoptive transfer of human MS into rhesus monkeys: Inhibition of the cellular immune response of rhesus monkeys to human PBMC in vitro by humanised antibodies against the IL-2 receptor α-chain

1997 ◽  
Vol 56 ◽  
pp. 313
Author(s):  
Herbert P.M. Brok ◽  
Cees W. de Groot ◽  
Bert A. 't Hart
Keyword(s):  
Immune Response ◽  
Adoptive Transfer ◽  
Cellular Immune Response ◽  
Rhesus Monkeys ◽  
Human Pbmc ◽  
Α Chain ◽  
Cellular Immune

scholarly journals In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection

10.3791/52121 ◽  
2014 ◽  
Author(s):  
Guorui Xie ◽  
Melissa C. Whiteman ◽  
Jason A. Wicker ◽  
Alan D.T. Barrett ◽  
Tian Wang
Keyword(s):  
Immune Response ◽  
West Nile Virus ◽  
Mutant Strain ◽  
Cellular Immune Response ◽  
West Nile ◽  
Virus Mutant ◽  
Cellular Immune

scholarly journals ANTIGEN RECOGNITION: IN VITRO STUDIES ON THE SPECIFICITY OF THE CELLULAR IMMUNE RESPONSE

1969 ◽  
Vol 130 (5) ◽  
pp. 1031-1045 ◽  
Author(s):  
Stuart F. Schlossman ◽  
Judith Herman ◽  
Arieh Yaron
Keyword(s):  
Immune Response ◽  
Lymph Node ◽  
Cellular Immune Response ◽  
Lymph Node Cell ◽  
Antigen Receptors ◽  
Lymph Node Cells ◽  
Cellular Immune ◽  
Conventional Antibody ◽  
Sensitive Population

Studies of the immunochemical specificity of antigen-induced thymidine-2-14C incorporation in lymph node cells obtained from animals immunized to a series of closely related α-DNP-oligolysines, ϵ-DNP-oligolysines, and oligolysines have shown that the sensitized cell exhibits an extraordinary degree of specificity for antigen. The sensitized cell is maximally stimulated by the homologous immunizing antigen and can discriminate among compounds which differ from one another only in the position of a dinitrophenyl group or D-lysine residue on an identical oligolysine backbone. These studies support the view that the immunogen is not degraded prior to the induction of the immune response, and that the majority of cells produced as a consequence of immunization have stereospecific antigen receptors for the DNP-oligolysine used to induce the response; a smaller and more variably sized population of cells is produced with receptors specific for the oligolysine portion of the immunizing antigen. When specifically sensitized lymph node cell cultures are stimulated in vitro by heterologous DNP-oligolysines, the oligolysine- and not the DNP-oligolysine-sensitive population of cells appears to play a crucial role in the specificity of such cross-reactions. It is concluded from these studies that the antigen receptor on the sensitized lymph node cell differs in both kind and degree from conventional antibody. The chemical nature of the receptor and the means by which this receptor reacts with antigen to initiate the biosynthetic or proliferative cellular immune response still remain undefined.

scholarly journals Suppression of in Vitro Cellular Immune Response by Nitrogen-Containing Terpene Alcohol Derivatives.

1996 ◽  
Vol 19 (11) ◽  
pp. 1443-1446 ◽  
Author(s):  
Yuji OKADA ◽  
Noriaki MATONO ◽  
Manzo SHIONO ◽  
Toshiyuki TAKAI ◽  
Masaki HIKIDA ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Cellular Immune

scholarly journals Cellular Immune Response of Rhesus Monkeys Infected with a Partially Attenuated nef Deletion Mutant of the Simian Immunodeficiency Virus

Virology ◽  
1995 ◽  
Vol 212 (2) ◽  
pp. 392-397 ◽  
Author(s):  
Ulf Dittmer ◽  
Thomas Nißlein ◽  
Walter Bodemer ◽  
Harald Petry ◽  
Ulrike Sauermann ◽  
...  
Keyword(s):  
Immune Response ◽  
Simian Immunodeficiency Virus ◽  
Cellular Immune Response ◽  
Rhesus Monkeys ◽  
Deletion Mutant ◽  
Immunodeficiency Virus ◽  
Cellular Immune
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