Short and long term analysis of heart rate variations in spontaneously hypertensive rats: effects of DSP-4 administration

2005 ◽  
Vol 59 ◽  
pp. S203-S208
Author(s):  
H. Kawamura ◽  
H. Mitsubayashi ◽  
T. Miao ◽  
T. Shimizu
Keyword(s):  
Heart Rate ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Short And Long Term ◽  
Term Analysis

Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats

2001 ◽  
Vol 281 (5) ◽  
pp. R1420-R1425 ◽  
Author(s):  
Ming-Guo Feng ◽  
Stephen A. W. Dukacz ◽  
Robert L. Kline
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Arterial Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Long Term Treatment ◽  
Wide Range ◽  
Short And Long Term

The present study assessed the short- and long-term effect of tempol, a membrane-permeable mimetic of superoxide dismutase, on renal medullary hemodynamics in spontaneously hypertensive rats (SHR). Tempol was given in the drinking water (1 mM) for 4 days or 7 wk (4–11 wk of age), and medullary blood flow (MBF) was measured over a wide range of renal arterial pressure by means of laser-Doppler flowmetry in anesthetized rats. In addition, the response of the medullary circulation to angiotensin II (5–50 ng · kg−1 · min−1 iv) was determined in SHR treated for 4 days with tempol. Compared with control SHR, short- and long-term treatment with tempol decreased arterial pressure by ∼20 mmHg and increased MBF by 35–50% without altering total renal blood flow (RBF) or autoregulation of RBF. Angiotensin II decreased RBF and MBF dose dependently (∼30% at the highest dose) in control SHR. In SHR treated with tempol, angiotensin II decreased RBF (∼30% at the highest dose) but did not alter MBF significantly. These data indicate that the antihypertensive effect of short- and long-term administration of tempol in SHR is associated with a selective increase in MBF. Tempol also reduced the sensitivity of MBF to angiotensin II. Taken together, these data support the idea that tempol enhances vasodilator mechanisms of the medullary circulation, possibly by interacting with the nitric oxide system. Increased MBF and reduced sensitivity of MBF to angiotensin II may contribute to the antihypertensive action of tempol in SHR.

Long-term administration of prazosin improves bladder storage function: Results from a study in spontaneously hypertensive rats

2011 ◽  
Vol 18 (11) ◽  
pp. 785-791 ◽  
Author(s):  
Nobuhiro Haga ◽  
Ken Aikawa ◽  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Masanori Nomiya ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Storage Function ◽  
Term Administration
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