Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship

James Cook; F. Christopher Zusi; Ivar M. McDonald; Dalton King; Matthew D. Hill; Christiana Iwuagwu; Robert A. Mate; Haiquan Fang; Rulin Zhao; Bei Wang; Jingfang Cutrone; Baoqing Ma; Qi Gao; Ronald J. Knox; Michele Matchett; Lizbeth Gallagher; Meredith Ferrante; Debra Post-Munson; Thaddeus Molski; Amy Easton; Regina Miller; Kelli Jones; Siva Digavalli; Francine Healy; Kimberley Lentz; Yulia Benitex; Wendy Clarke; Joanne Natale; Judith A. Siuciak; Nicholas Lodge; Robert Zaczek; Rex Denton; Daniel Morgan; Linda J. Bristow; John E. Macor; Richard E. Olson

doi:10.1021/acs.jmedchem.6b01506

Design and Synthesis of a New Series of 4-Heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure–Activity Relationship

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01506 ◽

2016 ◽

Vol 59 (24) ◽

pp. 11171-11181 ◽

Cited By ~ 12

Author(s):

James Cook ◽

F. Christopher Zusi ◽

Ivar M. McDonald ◽

Dalton King ◽

Matthew D. Hill ◽

...

Keyword(s):

Nicotinic Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Design And Synthesis ◽

Structure Activity

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FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship

Russian Journal of Bioorganic Chemistry ◽

10.1134/s1068162020060151 ◽

2020 ◽

Vol 46 (6) ◽

pp. 972-988

Author(s):

S. O. Kuranov ◽

O. A. Luzina ◽

N. F. Salakhutdinov

Keyword(s):

Structure Activity Relationship ◽

Hypoglycemic Agents ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity

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Discovery, structure–activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.07.012 ◽

2014 ◽

Vol 22 (17) ◽

pp. 4694-4703 ◽

Cited By ~ 8

Author(s):

Ming-Fu Cheng ◽

Li-Chin Ou ◽

Shu-Chun Chen ◽

Wan-Ting Chang ◽

Ping-Yee Law ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Agonists ◽

Structure Activity ◽

Opioid Receptor Agonists

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Design and Synthesis of N 4,N 9-Disubstituted Spermines for Non-viral siRNA Delivery – Structure-Activity Relationship Studies of siFection Efficiency Versus Toxicity

Pharmaceutical Research ◽

10.1007/s11095-008-9731-z ◽

2008 ◽

Vol 26 (2) ◽

pp. 286-295 ◽

Cited By ~ 14

Author(s):

Moustafa K. Soltan ◽

Hassan M. Ghonaim ◽

Mohamed El Sadek ◽

M. Abou Kull ◽

Lubna Abd El-aziz ◽

...

Keyword(s):

Sirna Delivery ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design And Synthesis ◽

Structure Activity

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Quantitative Structure-Activity Relationship Study on Some Azidopyridinyl Neonicotinoid Insecticides for Their Selective Affinity Towards the Drosophila Nicotinic Receptor Over Mammalian a4ß2 Receptor Using Electrotopological State Atom Index

Drug Design and Discovery ◽

10.3109/10559610290249557 ◽

2003 ◽

Vol 18 (2-3) ◽

pp. 81-89 ◽

Cited By ~ 1

Author(s):

Bikash Debnath ◽

Shovanlal Gayen ◽

Sudip Naskar ◽

Kunal Roy ◽

Tarun Jha

Keyword(s):

Nicotinic Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Neonicotinoid Insecticides ◽

Structure Activity ◽

Relationship Study ◽

Electrotopological State

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Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00487 ◽

2020 ◽

Author(s):

Huoming Huang ◽

Xinwei Li ◽

Wei Guo ◽

Chen Zhu ◽

Yuanyuan Qian ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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Design, synthesis, and structure–activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.061 ◽

2010 ◽

Vol 20 (24) ◽

pp. 7327-7330 ◽

Cited By ~ 16

Author(s):

Elizabeth M. Moir ◽

Kazuya Yoshiizumi ◽

Jim Cairns ◽

Phillip Cowley ◽

Morag Ferguson ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cb1 Receptor ◽

Activity Relationship ◽

Cannabinoid Cb1 Receptor ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Relationship Study

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Design and synthesis of novel antimicrobial peptides on the basis of α helical domain of Tenecin 1, an insect defensin protein, and structure–activity relationship study

Peptides ◽

10.1016/j.peptides.2005.08.016 ◽

2006 ◽

Vol 27 (4) ◽

pp. 640-648 ◽

Cited By ~ 24

Author(s):

Hye-sun Ahn ◽

Wonmi Cho ◽

Sun-Hee Kang ◽

Sung-Sin Ko ◽

Mi-Sun Park ◽

...

Keyword(s):

Antimicrobial Peptides ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design And Synthesis ◽

Helical Domain ◽

Structure Activity ◽

Insect Defensin ◽

Relationship Study

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Synthesis and Structure—Activity Relationship of Novel Benzoxazole Derivatives as Melatonin Receptor Agonists.

ChemInform ◽

10.1002/chin.200446124 ◽

2004 ◽

Vol 35 (46) ◽

Author(s):

Li-Qiang Sun ◽

et al. et al.

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Melatonin Receptor ◽

Receptor Agonists ◽

Structure Activity ◽

Melatonin Receptor Agonists ◽

Relationship Of

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Quantitative Structure-Activity Relationship Study on Some Azidopyridinyl Neonicotinoid Insecticides for Their Selective Affinity Towards the Drosophila Nicotinic Receptor Over Mammalian ?4?2 Receptor Using Electrotopological State Atom Index

Drug Design and Discovery ◽

10.1080/10559610290249557 ◽

2003 ◽

Vol 18 (2-3) ◽

pp. 81-89 ◽

Cited By ~ 1

Author(s):

BIKASH DEBNATH ◽

SHOVANLAL GAYEN ◽

SUDIP NASKAR ◽

KUNAL ROY ◽

TARUN JHA

Keyword(s):

Nicotinic Receptor ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Neonicotinoid Insecticides ◽

Structure Activity ◽

Relationship Study ◽

Electrotopological State

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Design, synthesis, and structure–activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.06.100 ◽

2005 ◽

Vol 15 (20) ◽

pp. 4574-4578 ◽

Cited By ~ 24

Author(s):

Weiguo Liu ◽

Steve Chen ◽

James Dropinski ◽

Lawrence Colwell ◽

Michael Robins ◽

...

Keyword(s):

Structure Activity Relationship ◽

Liver X Receptor ◽

Activity Relationship ◽

Potential Treatment ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Relationship Of

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