Preferential Crosslinking of Matrix-Attachment Region (MAR) Containing DNA Fragments to the Isolated Nuclear Matrix by Ionizing Radiation

Biochemistry ◽  
1995 ◽  
Vol 34 (39) ◽  
pp. 12790-12802 ◽  
Author(s):  
Usha Balasubramaniam ◽  
Nancy L. Oleinick
Keyword(s):  
Ionizing Radiation ◽  
Nuclear Matrix ◽  
Matrix Attachment Region ◽  
Dna Fragments ◽  
Attachment Region

scholarly journals Sequences Adjacent to oriP Improve the Persistence of Epstein-Barr Virus-Based Episomes in B Cells

2001 ◽  
Vol 75 (22) ◽  
pp. 11249-11252 ◽  
Author(s):  
Robert E. White ◽  
Richard Wade-Martins ◽  
Michael R. James
Keyword(s):  
B Cells ◽  
Nuclear Matrix ◽  
Epstein Barr Virus ◽  
Matrix Attachment Region ◽  
Nuclear Antigen ◽  
Adjacent Region ◽  
Barr Virus ◽  
Attachment Region ◽  
Nuclear Matrix Attachment Region ◽  
Epstein Barr

ABSTRACT Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spansoriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriPalone.

scholarly journals Scaffold/Matrix Attachment Region Elements Interact with a p300-Scaffold Attachment Factor A Complex and Are Bound by Acetylated Nucleosomes

2002 ◽  
Vol 22 (8) ◽  
pp. 2598-2606 ◽  
Author(s):  
Joost H. A. Martens ◽  
Matty Verlaan ◽  
Eric Kalkhoven ◽  
Josephine C. Dorsman ◽  
Alt Zantema
Keyword(s):  
Nuclear Matrix ◽  
Topoisomerase I ◽  
Matrix Attachment Region ◽  
Major Constituent ◽  
Regulation Of Transcription ◽  
Transcriptional Coactivator ◽  
Attachment Region ◽  
Attachment Factor ◽  
Coactivator P300 ◽  
I Gene

ABSTRACT The transcriptional coactivator p300 regulates transcription by binding to proteins involved in transcription and by acetylating histones and other proteins. These transcriptional effects are mainly at promoter and enhancer elements. Regulation of transcription also occurs through scaffold/matrix attachment regions (S/MARs), the chromatin regions that bind the nuclear matrix. Here we show that p300 binds to the S/MAR binding protein scaffold attachment factor A (SAF-A), a major constituent of the nuclear matrix. Using chromatin immunoprecipitations, we established that both p300 and SAF-A bind to S/MAR elements in the transiently silent topoisomerase I gene prior to its activation at G1 during cell cycle. This binding is accompanied by local acetylation of nucleosomes, suggesting that p300-SAF-A interactions at S/MAR elements of nontranscribed genes might poise these genes for transcription.

scholarly journals DNA polymorphism and epigenetic marks modulate the affinity of a scaffold/matrix attachment region to the nuclear matrix

2014 ◽  
Vol 22 (9) ◽  
pp. 1117-1123 ◽  
Author(s):  
Natalia P Kisseljova ◽  
Petr Dmitriev ◽  
Alexey Katargin ◽  
Elena Kim ◽  
Daria Ezerina ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Dna Polymorphism ◽  
Matrix Attachment Region ◽  
Epigenetic Marks ◽  
Attachment Region

Identification of a nuclear matrix attachment region like sequence in the last intron of PI3Kγ

2006 ◽  
Vol 341 (2) ◽  
pp. 583-590 ◽  
Author(s):  
Bingbing Dai ◽  
Lei Ying ◽  
Rong Cai ◽  
Ying Li ◽  
Xingqian Zhang ◽  
...  
Keyword(s):  
Nuclear Matrix ◽  
Matrix Attachment Region ◽  
Attachment Region ◽  
Nuclear Matrix Attachment Region
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