High-Resolution Four-Dimensional1H−13C NOE Spectroscopy using Methyl-TROSY, Sparse Data Acquisition, and Multidimensional Decomposition

2005 ◽  
Vol 127 (8) ◽  
pp. 2767-2775 ◽  
Author(s):  
Vitali Tugarinov ◽  
Lewis E. Kay ◽  
Ilghiz Ibraghimov ◽  
Vladislav Yu. Orekhov
Keyword(s):  
High Resolution ◽  
Data Acquisition ◽  
Sparse Data ◽  
Methyl Trosy

Sparse data acquisition and its influence on imaging

2000 ◽  
Author(s):  
Jeroen Groenenboom ◽  
Evert C. Slob
Keyword(s):  
Data Acquisition ◽  
Sparse Data

scholarly journals Analogue aerial-photopraphs external orientation reconstruction based on geoportal data

2011 ◽  
Vol 30 (3) ◽  
pp. 13-18
Author(s):  
Piotr Dzieszko
Keyword(s):  
Information Systems ◽  
High Resolution ◽  
Data Acquisition ◽  
Geographical Information Systems ◽  
Fast Growth ◽  
Geographical Information ◽  
Source Data ◽  
Effective Choice ◽  
Field Works ◽  
Very High

Analogue aerial-photopraphs external orientation reconstruction based on geoportal data For acquisition of source data for geoinformation analyses is necessary to do some field works. This way of data acquisition is time-consuming. In this case, photogrammetric and remote sensed methods can be more effective choice. Especially orthophotomap extracting is more effective process in creation of geodata. It is good foundation for further analysis and nice extension of existing geographical information systems. Despite fast growth of photogrammetry there are plenty of analogue, archival airphotos which can be used for geoinformation analysis. They are quiet up to date and scanned in very high resolution which means they can be used for really reliable analysis. The problem is very important because many of analogue, archival air photos do not contain photogrammetric warp. The aim of this paper is expression of applicability of geoportal webpage, which is part of INSPIRE directive, that can be used for external orientation reconstruction when there is no other georeference data.

High resolution cross‐well imaging of a west texas carbonate reservoir: Part 1. Data acquisition and project overview

1992 ◽  
Author(s):  
J. M. Harris ◽  
Richard Nolen‐Hoeksema ◽  
J. W. Rector ◽  
M. Van Schaack ◽  
S. K. Lazaratos
Keyword(s):  
High Resolution ◽  
Data Acquisition ◽  
Carbonate Reservoir ◽  
West Texas

scholarly journals Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window Acquisition of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology

2019 ◽  
Vol 65 (7) ◽  
pp. 862-870 ◽  
Author(s):  
Jeffrey D Whitman ◽  
Kara L Lynch
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Data Acquisition ◽  
High Resolution Mass Spectrometry ◽  
Limit Of Detection ◽  
Clinical Toxicology ◽  
Urine Samples ◽  
Analytical Sensitivity ◽  
High Resolution Mass ◽  
Resolution Mass

Abstract BACKGROUND Untargeted data acquisition on high-resolution mass spectrometers (HRMSs) has been used in clinical toxicology for screening and identifying unknown compounds in patient samples. A common modality for untargeted HRMS data acquisition is information-dependent acquisition (IDA), which analyzes the most abundant small molecules within an acquisition cycle. This process can potentially lead to false negatives of clinically relevant compounds at low concentrations. Sequential window acquisition of all theoretical fragment ion spectra (SWATH) has emerged as a method of unbiased, untargeted HRMS data acquisition in which no spectral data are lost. SWATH has yet to be optimized and assessed for use in clinical toxicology. METHOD We developed a variable-window SWATH method (vSWATH) and compared it to IDA by limit of detection studies in drug-supplemented urine (81 compounds) and against a retrospective cohort of 50 clinical urine samples characterized by LC-MS/MS. RESULTS vSWATH had a lower limit of detection than IDA for 33 (41%) drugs and metabolites added into urine samples. Both IDA and vSWATH were equivalent in discovering compounds from clinical urine samples and confirmed 26 additional compounds not previously discovered by targeted LC-MS/MS. Lastly, the unbiased acquisition of spectra in vSWATH allowed for identification of 5 low-abundance compounds missed by IDA. CONCLUSIONS This vSWATH method for clinical toxicology demonstrated equivalent analytical sensitivity and specificity for untargeted drug screening and identification in urine samples. vSWATH provided the additional benefit of collecting all tandem mass spectrometry spectra in a sample, which could be useful in discovering low-abundance compounds not discovered by IDA.

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