The control chart and the maintenance management need to control process quality and reduce out-of-control cost. They are two key tools in the production process; however, they have usually been analyzed separately in the literature. Moreover, the existing studies integrating these two concepts suffer from three significant drawbacks as follows: (1) using control charts with fixed parameters to monitor the process, so that the small and middle shifts are detected slowly; (2) monitoring the mean and standard deviation separately, whereas, in real condition, the mean and standard deviation should be monitored simultaneously; (3) quality loss function is not usually used to design economic model, which leads to a large social quality loss in the monitoring process of control chart. To eliminate these weaknesses, the economic design of the exponential weighted moving average (EWMA) control chart with variable sampling intervals (VSI) for monitoring the mean and standard deviation under preventive maintenance and Taguchi’s loss functions is proposed. The optimal values of the parameters are determined to minimize the loss-per-item in an average cycle process. In addition, a genetic algorithm is used in a numerical example to search for the optimal values of the parameters. According to the sensitivity analysis, the effect of the model parameters on the solution of the economic model is obtained. Finally, the comparison study shows that the VSI EWMA control charts designed by the joint economic model are expected to reduce loss.