Role of Active Research in Recruiting and Retaining Psychologists

2006 ◽  
Author(s):  
Ann Louise Barrick
Keyword(s):  
Active Research

scholarly journals The Role of the School library and the School librarian in the context of new curricula

2019 ◽  
Author(s):  
Ivana Perić ◽  
Danijela Riger-Knez ◽  
Tanja Telesmanić ◽  
Hajdi Škarica ◽  
Mišela Nežić
Keyword(s):  
New Technologies ◽  
School Library ◽  
Literacy Education ◽  
School Librarians ◽  
Life Long Learning ◽  
Starting Point ◽  
Active Research ◽  
Educational Staff ◽  
New Curricula

Concerning the development and the opportunities provided by new technologies and changes in social reality, the task of educational staff is to raise and educate responsible participants in the learning process adaptable to new situations of learning in the digital age, the age of vast information, and therefore be prepared for life-long learning. As school librarians are recognised as educated and essential collaborators in this task, which is common to all educational staff, it is necessary to operationalise their role in the educational system in Croatia and encourage development of new curricula. This paper proposes a framework for a programme, which has a starting point in new subject curricula and extra-curricula topics. It starts from the constructivist approach of teaching where at the core are students who do not memorize facts but are capable of solving problems through active research and interaction with information and thus creating new knowledge. This approach encourages students to be critical thinkers, express themselves freely, be creative and strengthen their confidence in their quest to acquire competencies that develop the proposed framework for a library programme in information and media literacy education, and promoting reading.

scholarly journals Role of Hydrogen Sulfide in the Pathology of Inflammation

Scientifica ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Madhav Bhatia
Keyword(s):  
Hydrogen Sulfide ◽  
Joint Inflammation ◽  
Chronic Obstructive ◽  
Therapeutic Approaches ◽  
Obstructive Pulmonary Disease ◽  
The Past ◽  
Inflammatory Conditions ◽  
Incurable Disease ◽  
Active Research

Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase. In the past few years, H2S has emerged as a novel and increasingly important biological mediator. Imbalances in H2S have also been shown to be associated with various disease conditions. However, defining the precise pathophysiology of H2S is proving to be a complex challenge. Recent research in our laboratory has shown H2S as a novel mediator of inflammation and work in several groups worldwide is currently focused on determining the role of H2S in inflammation. H2S has been implicated in different inflammatory conditions, such as acute pancreatitis, sepsis, joint inflammation, and chronic obstructive pulmonary disease (COPD). Active research on the role of H2S in inflammation will unravel the pathophysiology of its actions in inflammatory conditions and may help develop novel therapeutic approaches for several, as yet incurable, disease conditions.

The Price of Experience

2015 ◽  
Vol 105 (2) ◽  
pp. 784-815 ◽  
Author(s):  
Hyeok Jeong ◽  
Yong Kim ◽  
Iourii Manovskii
Keyword(s):  
Life Cycle ◽  
Labor Economics ◽  
Age Groups ◽  
Demographic Changes ◽  
Cross Sectional ◽  
Empirical Regularities ◽  
Active Research ◽  
Education Groups ◽  
College Premium

We identify a key role of factor supply, driven by demographic changes, in shaping several empirical regularities that are a focus of active research in macro and labor economics. In particular, demographic changes alone can account for the large movements of the return to experience over the last four decades, for the differential dynamics of the age premium across education groups emphasized by Katz and Murphy (1992), for the differential dynamics of the college premium across age groups emphasized by Card and Lemieux (2001), and for the changes in cross-sectional and cohort-based life-cycle profiles emphasized by Kambourov and Manovskii (2005). (JEL D91, E24, I23, J11, J24, J31)

scholarly journals Vasoactive factors in the preeclampsia pathogenesis

2006 ◽  
Vol 12 (1) ◽  
pp. 22-31
Author(s):  
V. .. Reznic
Keyword(s):  
High Risk ◽  
Fetal Outcome ◽  
Severe Preeclampsia ◽  
Clinical Marker ◽  
Vasoactive Factors ◽  
Underlying Causes ◽  
Active Research ◽  
Prospective Longitudinal ◽  
Risk Of Preeclampsia

Preeclampsia-eclampsia is still one oi the leading causes of maternal and fetal morbidity and mortality. Despite active research for many years, the etiology of this disorder exclusive to human pregnancy is enigma. Recent evidence suggests there may be several underlying causes or predispositions leading to the signs of hypertension, proteinuria and edema, findings that allow us to make ithe diagnosis of the «syndrome» of preeclampsia. Despite improved prenatal care, severe preeclampsia and eclampsia still occur. Although understanding of the pal pathophysiology of there disordes has improved, treatment has not changed significantly in over 30 years. Although postponement of delivery in selected women with severe preeclampsia improves fetal outcome to a degree, this is not done without risk to the mot her. The search for the underlying cause of this disorder and for a clinical marker to predict those women who will develop preeclampsia-eclampsia is ongoing, with its prevention the ultimate goal. Moreover, prospective longitudinal studies are needed to better assess the role of circulating angiogenic factors for the identification women at high risk of preeclampsia and the early diagnosis of disease.

scholarly journals The enzyme succinate dehydrogenase (SDH) and its role in hereditary pituitary adenomas

2013 ◽  
Vol 10 (4) ◽  
pp. 10-15
Author(s):  
Iu V Pankratova ◽  
E G Przhiyalkovskaya ◽  
E A Pigarova ◽  
L K Dzeranova
Keyword(s):  
Pituitary Adenomas ◽  
Multiple Endocrine Neoplasia ◽  
Germline Mutations ◽  
Genetic Defects ◽  
Hereditary Syndromes ◽  
Pituitary Tumorigenesis ◽  
Active Research ◽  
Familial Pituitary Adenomas

Despite active research involving familial pituitary adenomas and characterization of five hereditary syndromes, the genetic defects in more than 80 - 95% of patients remain not found. Besides, there is more than 25 cases of coexistence of pheochromocytomas and pituitary adenomas described in literature that up to date is not integrated in any syndrome; genetic defects of such coexistence also aren't defined. However it is supposed that in pituitary tumorigenesis, germline mutations of SDH can take part that is obviously important aspect of further investigation. Germline mutations of SDH were found in patients with different phenotypes of pituitary adenomas. Studying of mutations in genes SDHD, SDHB, SDHC, SDHA and their prevalence in patients with familial pituitary adenomas or with phenotypes of multiple endocrine neoplasia without mutations in MEN1, CDKN1B, PRKAR1A, AIP genes can provide clarity in a role of mutations in SDH in endocrine and in particular pituitary tumorigenesis.

scholarly journals Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1395
Author(s):  
A. V. Suslov ◽  
M. A. Afanasyev ◽  
P. A. Degtyarev ◽  
P. V. Chumachenko ◽  
M. Bagheri Ekta ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Wall ◽  
Morphological Changes ◽  
Genetic Disorders ◽  
Threatening Condition ◽  
Mitochondrial Pathology ◽  
Active Research ◽  
Mitochondrial Dna Heteroplasmy

Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.

scholarly journals Mapping diversification metrics in macroecological studies: Prospects and challenges

2018 ◽  
Author(s):  
Julián A. Velasco ◽  
Jesús N. Pinto-Ledezma
Keyword(s):  
Species Richness ◽  
Phylogenetic Trees ◽  
Evolutionary Mechanisms ◽  
Geographical Patterns ◽  
Research Areas ◽  
Evolutionary Distinctiveness ◽  
Branch Lengths ◽  
Spatial Diversification ◽  
Active Research

AbstractThe intersection of macroecology and macroevolution is one of the most active research areas today. Macroecological studies are increasingly using phylogenetic diversification metrics to explore the role of evolutionary processes in shaping present-day patterns of biodiversity. Evolutionary explanations of species richness gradients are key for our understanding of how diversity accumulated in a region. For instance, the present-day diversity in a region can be a result of in situ diversification, extinction, or colonization from other regions, or a combination of all of these processes. However, it is unknown whether these metrics capture well these diversification and dispersal processes across geography. Some metrics (e.g., mean root distance -MRD-; lineage diversification-rate -DR-; evolutionary distinctiveness -ED-) seem to provide very similar geographical patterns regardless of how they were calculated (e.g., using branch lengths or not). The lack of appropriate estimates of extinction and dispersal rates in phylogenetic trees can limit our conclusions about how species richness gradients emerged. With a review of the literature and complemented by an empirical comparison, we show that phylogenetic metrics by itself are not capturing well the speciation, extinction and dispersal processes across the geographical gradients. Furthermore, we show how new biogeographic methods can improve our inference of past events and therefore our conclusions about the evolutionary mechanisms driving regional species richness. Finally, we recommend that future studies include several approaches (e.g., spatial diversification modelling, parametric biogeographic methods) to disentangle the relative the role of speciation, extinction and dispersal in the generation and maintenance of species richness gradients.

Information Retrieval Models

2017 ◽  
pp. 17-42 ◽  
Author(s):  
Saruladha Krishnamurthy ◽  
Akila V
Keyword(s):  
Information Retrieval ◽  
Research Field ◽  
Process Models ◽  
Retrieval Models ◽  
Retrieval Systems ◽  
Information Retrieval Systems ◽  
External Sources ◽  
Active Research ◽  
Cross Lingual

Information retrieval is currently an active research field with the evolution of World wide web. The objective of this chapter is to provide an insight into the information retrieval definitions, process, models. Further how traditional information retrieval has evolved and adapted for search engines is also discussed. The information retrieval models have not only been used for search purpose it also supports cross lingual translation and retrieval tasks. This chapter also outlines the CLIR process in a brief manner. The tools which are usually used for experimental and research purpose is also discussed. This chapter is organized as Introduction to the concepts of information retrieval. Description of the information retrieval process, the information retrieval models, the role of external sources like ontologies in information retrieval systems. Finally the chapter provides an overview of CLIR and the tools used in developing IR systems is mentioned. Further the latest research directions in IR is explained.

Olaratumab in the management of advanced soft tissue sarcoma

2018 ◽  
Vol 25 (2) ◽  
pp. 442-448 ◽  
Author(s):  
Chrystia M Zobniw ◽  
Van Anh Trinh ◽  
Kristi Posey ◽  
Neeta Somaiah
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Survival Data ◽  
Pediatric Population ◽  
Advanced Soft Tissue Sarcoma ◽  
Phase 3 ◽  
Management Algorithm ◽  
Active Research ◽  
Confirmatory Phase

Olaratumab, the first-in-class anti-PDGFRα monoclonal antibody, has been contingently approved in combination with doxorubicin to treat adult patients with advanced soft tissue sarcoma for improving progression-free and overall survival. Olaratumab–doxorubicin combination has tolerable safety profile, which mimics that of doxorubicin monotherapy, with the exception of infusion-related reactions. Survival data of an ongoing confirmatory phase 3 trial are forthcoming to ascertain the optimal role of this product in the management algorithm of advanced soft tissue sarcoma. Active research is ongoing to identify biomarkers predictive of clinical benefit to olaratumab, to expand its utility to the pediatric population, and to explore its safety and efficacy in combination with other active regimens.

scholarly journals Toward Understanding the Role of Aryl Hydrocarbon Receptor in the Immune System: Current Progress and Future Trends

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Hamza Hanieh
Keyword(s):  
Immune System ◽  
Aryl Hydrocarbon Receptor ◽  
Immune Cells ◽  
Immune Cell ◽  
Current Knowledge ◽  
Physiological Role ◽  
Clinical Practices ◽  
Aryl Hydrocarbon ◽  
Active Research

The immune system is regulated by distinct signaling pathways that control the development and function of the immune cells. Accumulating evidence suggest that ligation of aryl hydrocarbon receptor (Ahr), an environmentally responsive transcription factor, results in multiple cross talks that are capable of modulating these pathways and their downstream responsive genes. Most of the immune cells respond to such modulation, and many inflammatory response-related genes contain multiple xenobiotic-responsive elements (XREs) boxes upstream. Active research efforts have investigated the physiological role of Ahr in inflammation and autoimmunity using different animal models. Recently formed paradigm has shown that activation of Ahr by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3′-diindolylmethane (DIM) prompts the differentiation of CD4+Foxp3+regulatory T cells (Tregs) and inhibits T helper (Th)-17 suggesting that Ahr is an innovative therapeutic strategy for autoimmune inflammation. These promising findings generate a basis for future clinical practices in humans. This review addresses the current knowledge on the role of Ahr in different immune cell compartments, with a particular focus on inflammation and autoimmunity.

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