scholarly journals Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Jin Sun ◽  
Hui-Min Wei ◽  
Jiang Xu ◽  
Jian-Feng Chang ◽  
Zhihao Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Epigenetic Regulation ◽  
Histone H1 ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
H4k16 Acetylation

scholarly journals Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal

2012 ◽  
Vol 2 (3) ◽  
pp. 343-351 ◽  
Author(s):  
Yalan Xing ◽  
Irina Kurtz ◽  
Manisha Thuparani ◽  
Jillian Legard ◽  
Hannele Ruohola-Baker
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Loss Of Function ◽  
Self Renewal

scholarly journals The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation

Blood ◽  
2013 ◽  
Vol 122 (16) ◽  
pp. 2812-2822 ◽  
Author(s):  
Tao Wang ◽  
Vijayalakshmi Nandakumar ◽  
Xiao-Xia Jiang ◽  
Lindsey Jones ◽  
An-Gang Yang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Histone Modifications ◽  
Epigenetic Regulation ◽  
Self Renewal ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Key Points ◽  
And Function ◽  
Cell Maintenance

Key Points Mysm1 is required to maintain the quiescence and pool size of HSC, and its deletion severely impairs the survival and function of HSC. Mysm1 controls HSC homeostasis by regulating Gfi1 expression via modulating histone modifications and transcriptional factors recruitment.

scholarly journals A Drosophila Chromatin Factor Interacts With the Piwi-Interacting RNA Mechanism in Niche Cells to Regulate Germline Stem Cell Self-Renewal

Genetics ◽  
2010 ◽  
Vol 186 (2) ◽  
pp. 573-583 ◽  
Author(s):  
Tora K. Smulders-Srinivasan ◽  
Akos Szakmary ◽  
Haifan Lin
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Self Renewal

scholarly journals Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

2017 ◽  
Vol 41 (2) ◽  
pp. 157-169.e5 ◽  
Author(s):  
Xing Ma ◽  
Xiujuan Zhu ◽  
Yingying Han ◽  
Benjamin Story ◽  
Trieu Do ◽  
...  
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Self Renewal

scholarly journals eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in theDrosophilaovary

2009 ◽  
Vol 106 (28) ◽  
pp. 11623-11628 ◽  
Author(s):  
Run Shen ◽  
Changjiang Weng ◽  
Junjing Yu ◽  
Ting Xie
Keyword(s):  
Stem Cell ◽  
Germline Stem Cell ◽  
Self Renewal

Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche

2020 ◽  
Vol 168 (6) ◽  
pp. 589-602
Author(s):  
Marika Rikitake ◽  
Ayako Matsuda ◽  
Daisuke Murata ◽  
Katsufumi Dejima ◽  
Kazuko H Nomura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Lipid Rafts ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

Abstract Stem cells divide and undergo self-renewal depending on the signals received from the stem cell niche. This phenomenon is indispensable to maintain tissues and organs in individuals. However, not all the molecular factors and mechanisms of self-renewal are known. In our previous study, we reported that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) synthesized in the distal tip cells (DTCs; the stem cell niche) are essential for germline stem cell proliferation in Caenorhabditis elegans. Here, we characterized the GPI-APs required for proliferation. We selected and verified the candidate GPI-APs synthesized in DTCs by RNA interference screening and found that F57F4.3 (GFI-1), F57F4.4 and F54E2.1 are necessary for germline proliferation. These proteins are likely involved in the same pathway for proliferation and activated by the transcription factor PQM-1. We further provided evidence suggesting that these GPI-APs act through fatty acid remodelling of the GPI anchor, which is essential for association with lipid rafts. These findings demonstrated that GPI-APs, particularly F57F4.3/4 and F54E2.1, synthesized in the germline stem cell niche are located in lipid rafts and involved in promoting germline stem cell proliferation in C. elegans. The findings may thus shed light on the mechanisms by which GPI-APs regulate stem cell self-renewal.

scholarly journals Translational control in germline stem cell development

2014 ◽  
Vol 207 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Maija Slaidina ◽  
Ruth Lehmann
Keyword(s):  
Stem Cell ◽  
Translational Control ◽  
Regulatory Networks ◽  
Feedback Loops ◽  
Translational Repression ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Genetic Studies ◽  
Organ Growth ◽  
Fate Decision

Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision.

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