scholarly journals Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Martin Thunemann ◽  
Barbara F. Schörg ◽  
Susanne Feil ◽  
Yun Lin ◽  
Jakob Voelkl ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Cell Populations ◽  
Specific Cell ◽  
Non Invasive ◽  
Positron Emission

scholarly journals Non-invasive imaging of high-risk coronary plaque: the role of computed tomography and positron emission tomography

2020 ◽  
Vol 93 (1113) ◽  
pp. 20190740 ◽  
Author(s):  
Rong Bing ◽  
Krithika Loganath ◽  
Philip Adamson ◽  
David Newby ◽  
Alastair Moss
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Coronary Plaque ◽  
Emission Tomography ◽  
Plaque Morphology ◽  
Biological Processes ◽  
Non Invasive ◽  
Positron Emission

Despite recent advances, cardiovascular disease remains the leading cause of death globally. As such, there is a need to optimise our current diagnostic and risk stratification pathways in order to better deliver individualised preventative therapies. Non-invasive imaging of coronary artery plaque can interrogate multiple aspects of coronary atherosclerotic disease, including plaque morphology, anatomy and flow. More recently, disease activity is being assessed to provide mechanistic insights into in vivo atherosclerosis biology. Molecular imaging using positron emission tomography is unique in this field, with the potential to identify specific biological processes using either bespoke or re-purposed radiotracers. This review provides an overview of non-invasive vulnerable plaque detection and molecular imaging of coronary atherosclerosis.

scholarly journals Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nobuo Suzui ◽  
Takuya Shibata ◽  
Yong-Gen Yin ◽  
Yoshihito Funaki ◽  
Keisuke Kurita ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sodium Iodide ◽  
Emission Tomography ◽  
Sodium Ions ◽  
Living Animal ◽  
Non Invasive ◽  
Positron Emission ◽  
Tracer Solution ◽  
The Impact

Abstract Visualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.

scholarly journals Diagnosis of Pancreatic Ductal Adenocarcinoma by Immuno-Positron Emission Tomography

2021 ◽  
Vol 10 (6) ◽  
pp. 1151
Author(s):  
Ruth González-Gómez ◽  
Roberto A. Pazo-Cid ◽  
Luis Sarría ◽  
Miguel Ángel Morcillo ◽  
Alberto J. Schuhmacher
Keyword(s):  
Positron Emission Tomography ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Imaging Techniques ◽  
Metastatic Tumor ◽  
Emission Tomography ◽  
Whole Body ◽  
Ductal Adenocarcinoma ◽  
Non Invasive ◽  
Positron Emission

Diagnosis of pancreatic ductal adenocarcinoma (PDAC) by current imaging techniques is useful and widely used in the clinic but presents several limitations and challenges, especially in small lesions that frequently cause radiological tumors infra-staging, false-positive diagnosis of metastatic tumor recurrence, and common occult micro-metastatic disease. The revolution in cancer multi-“omics” and bioinformatics has uncovered clinically relevant alterations in PDAC that still need to be integrated into patients’ clinical management, urging the development of non-invasive imaging techniques against principal biomarkers to assess and incorporate this information into the clinical practice. “Immuno-PET” merges the high target selectivity and specificity of antibodies and engineered fragments toward a given tumor cell surface marker with the high spatial resolution, sensitivity, and quantitative capabilities of positron emission tomography (PET) imaging techniques. In this review, we detail and provide examples of the clinical limitations of current imaging techniques for diagnosing PDAC. Furthermore, we define the different components of immuno-PET and summarize the existing applications of this technique in PDAC. The development of novel immuno-PET methods will make it possible to conduct the non-invasive diagnosis and monitoring of patients over time using in vivo, integrated, quantifiable, 3D, whole body immunohistochemistry working like a “virtual biopsy”.

scholarly journals Diagnosis of Glioblastoma by Immuno-Positron Emission Tomography

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 74
Author(s):  
Eduardo Ruiz-López ◽  
Juan Calatayud-Pérez ◽  
Irene Castells-Yus ◽  
María José Gimeno-Peribáñez ◽  
Noelia Mendoza-Calvo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Biopsy ◽  
Molecular Classification ◽  
Final Diagnosis ◽  
Emission Tomography ◽  
Invasive Technique ◽  
Tumor Type ◽  
Non Invasive ◽  
Positron Emission

Neuroimaging has transformed neuro-oncology and the way that glioblastoma is diagnosed and treated. Magnetic Resonance Imaging (MRI) is the most widely used non-invasive technique in the primary diagnosis of glioblastoma. Although MRI provides very powerful anatomical information, it has proven to be of limited value for diagnosing glioblastomas in some situations. The final diagnosis requires a brain biopsy that may not depict the high intratumoral heterogeneity present in this tumor type. The revolution in “cancer-omics” is transforming the molecular classification of gliomas. However, many of the clinically relevant alterations revealed by these studies have not yet been integrated into the clinical management of patients, in part due to the lack of non-invasive biomarker-based imaging tools. An innovative option for biomarker identification in vivo is termed “immunotargeted imaging”. By merging the high target specificity of antibodies with the high spatial resolution, sensitivity, and quantitative capabilities of positron emission tomography (PET), “Immuno-PET” allows us to conduct the non-invasive diagnosis and monitoring of patients over time using antibody-based probes as an in vivo, integrated, quantifiable, 3D, full-body “immunohistochemistry” in patients. This review provides the state of the art of immuno-PET applications and future perspectives on this imaging approach for glioblastoma.

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