Simple ZnEt2as a catalyst in carbodiimide hydroalkynylation: structural and mechanistic studies

2017 ◽  
Vol 46 (38) ◽  
pp. 12923-12934 ◽  
Author(s):  
Antonio Martínez ◽  
Sonia Moreno-Blázquez ◽  
Antonio Rodríguez-Diéguez ◽  
Alberto Ramos ◽  
Rafael Fernández-Galán ◽  
...  
Keyword(s):  
Terminal Alkynes ◽  
Mechanistic Studies ◽  
Efficient Catalyst

Simple ZnEt2is an efficient catalyst for the addition of terminal alkynes to carbodiimides, through amidinate complexes, and consecutive isocyanate addition and intramolecular cyclohydroamination.

Magnetically recoverable graphene-based nanocomposite material as an efficient catalyst for the synthesis of propargylamines via A3 coupling reaction

2017 ◽  
Vol 41 (21) ◽  
pp. 12756-12766 ◽  
Author(s):  
Najrul Hussain ◽  
Manash R. Das
Keyword(s):  
Functional Groups ◽  
Coupling Reaction ◽  
Secondary Amines ◽  
Terminal Alkynes ◽  
Efficient Catalyst ◽  
Au Nps ◽  
Efficient Route ◽  
Magnetically Separable ◽  
High Yields ◽  
A3 Coupling

The magnetically separable Au NPs–Fe3O4–rGO catalyst provides a robust and efficient route for the A3 coupling reaction of secondary amines, terminal alkynes and aldehyde with tolerance of diverse functional groups for the synthesis of propargylamine in high yields.

scholarly journals Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides

2017 ◽  
Vol 59 (2) ◽  
Author(s):  
Heraclio López-Ruiz
Keyword(s):  
Microwave Heating ◽  
Room Temperature ◽  
Phenylboronic Acid ◽  
Terminal Alkynes ◽  
Efficient Catalyst ◽  
Alkyl Azides ◽  
Terminal Acetylenes

<p>The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkyl azides and terminal alkynes at room temperature and under microwave heating was attained using Cu(I), generated <em>in-situ </em>from copper(II) sulfate and phenylboronic acid, as catalyst. Twelve new triazoles were obtained in moderate to good yields (53-98%), and the products were obtained by crystallization from the mixture reaction without further purification.</p>

scholarly journals Co-Catalyzed E-(β)-Selective Hydrogermylation of Terminal Alkynes

2021 ◽  
Author(s):  
Maxim Radzhabov ◽  
Neal Mankad
Keyword(s):  
Natural Products ◽  
Late Stage ◽  
Functional Group ◽  
Terminal Alkynes ◽  
Mechanistic Studies ◽  
Practical Utility ◽  
Π Complex ◽  
Accessible Method ◽  
High Yields

<a></a><a>We demonstrated unprecedentedly that Co complexes can catalyze hydrogermylation of alkynes. Subsequently, a selective, accessible method was developed to synthesize E-(β)-vinyl(trialkyl)germanes from various terminal alkynes with high yields. As shown on multiple examples, the developed method demonstrates broad functional group tolerance and practical utility for late-stage hydrogermylation of drugs and natural products. The method is compatible with alkynes bearing both aryl and alkyl substituents, providing unrivaled selectivity for previously challenging 1° alkyl-substituted alkynes. Moreover, the catalyst used in this method, Co<sub>2</sub>(CO)<sub>8</sub>, is a cheap and commercially available reagent. Conducted mechanistic studies supported syn-addition of Bu<sub>3</sub>GeH to an alkyne</a> π-complex.

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