Two one-dimensional arrays of naphthyl and anthryl groups along peptide nanotubes prepared from cyclic peptides comprising α- and β-amino acids

Soft Matter ◽  
2018 ◽  
Vol 14 (37) ◽  
pp. 7597-7604 ◽  
Author(s):  
Yuki Tabata ◽  
Hirotaka Uji ◽  
Tomoya Imai ◽  
Shunsaku Kimura
Keyword(s):  
Amino Acids ◽  
Electronic Properties ◽  
Cyclic Peptides ◽  
Molecular Assembly ◽  
Peptide Nanotubes ◽  
One Dimensional ◽  
Cyclic Hexapeptide

A novel cyclic hexapeptide composed of l-α-naphthylalanine, d-α-anthrylalanine, and four β-alanines (CP6) is synthesized and its molecular assembly into peptide nanotubes (PNTs) and the electronic properties arising from one-dimensional arrays of aromatic groups along the PNTs are investigated.

scholarly journals New self-assembling peptide nanotubes of large diameter using δ-amino acids

2018 ◽  
Vol 9 (43) ◽  
pp. 8228-8233 ◽  
Author(s):  
Alejandro Lamas ◽  
Arcadio Guerra ◽  
Manuel Amorín ◽  
Juan R. Granja
Keyword(s):  
Amino Acids ◽  
Building Block ◽  
Cyclic Peptides ◽  
Large Diameter ◽  
Peptide Nanotubes ◽  
Self Assembling ◽  
Aminocyclohexanecarboxylic Acid

Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores.

scholarly journals Transmembrane Self-Assembled Cyclic Peptide Nanotubes Based on α‐Residues and Cyclic δ‐Amino Acids: A Computational Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Alexandre Blanco-González ◽  
Martín Calvelo ◽  
Pablo F. Garrido ◽  
Manuel Amorín ◽  
Juan R. Granja ◽  
...  
Keyword(s):  
Amino Acids ◽  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Computational Study ◽  
Peptide Nanotubes ◽  
Peptide Motifs ◽  
Self Assembling ◽  
Transmembrane Channels ◽  
Dynamics Simulations ◽  
Cyclic Peptide Nanotubes

Self-assembling cyclic peptide nanotubes have been shown to function as synthetic, integral transmembrane channels. The combination of natural and nonnatural aminoacids in the sequence of cyclic peptides enables the control not only of their outer surface but also of the inner cavity behavior and properties, affecting, for instance, their permeability to different molecules including water and ions. Here, a thorough computational study on a new class of self-assembling peptide motifs, in which δ-aminocycloalkanecarboxylic acids are alternated with natural α-amino acids, is presented. The presence of synthetic δ-residues creates hydrophobic regions in these α,δ-SCPNs, which makes them especially attractive for their potential implementation in the design of new drug or diagnostic agent carrier systems. Using molecular dynamics simulations, the behavior of water molecules, different ions (Li+, Na+, K+, Cs+, and Ca2+), and their correspondent counter Cl− anions is extensively investigated in the nanoconfined environment. The structure and dynamics are mutually combined in a diving immersion inside these transmembrane channels to discover a fascinating submarine nanoworld where star-shaped water channels guide the passage of cations and anions therethrough.

PAPER CHROMATOGRAPHY OF COMPLEX BIOLOGICAL MATERIALS BY SOLVENT REDEVELOPMENT WITHOUT PRIOR REMOVAL OF SALTS OR PROTEINS

1960 ◽  
Vol 38 (10) ◽  
pp. 1137-1147 ◽  
Author(s):  
Arthur E. Pasieka
Keyword(s):  
Amino Acids ◽  
Paper Chromatography ◽  
Filter Paper ◽  
Complex Mixtures ◽  
Two Dimensional ◽  
One Dimensional ◽  
Equivalent Time ◽  
Biological Compounds ◽  
High Concentrations ◽  
Subsequent Staining

A solvent redeveloping technique has been devised by which amino acids, peptides, and sugars can be separated from complex mixtures in the presence of high concentrations of salts and proteins. The separations are effected by two to four successive 18-hour solvent developments with drying between each 18-hour period before subsequent staining of the chromatograms. Better separations and resolutions are obtained by such successive 18-hour solvent developments than by one continuous solvent development for an equivalent time. The effect of these redevelopments on the separations and resolutions of biological compounds is illustrated at various stages by photographs of one- and two-dimensional chromatograms. The redevelopment technique requires filter paper sheets up to 4 ft in length for one-dimensional analytical and preparative types of chromatograms.

A Comprehensive Study on the Effect of Backbone Stereochemistry of a Cyclic Hexapeptide on Membrane Permeability and Microsomal Stability

2021 ◽  
Author(s):  
Yuki Hosono ◽  
Jumpei Morimoto ◽  
Shinsuke Sando
Keyword(s):  
Membrane Permeability ◽  
Oral Bioavailability ◽  
Cyclic Peptides ◽  
Great Influence ◽  
Cyclic Hexapeptide ◽  
Comprehensive Study

Backbone stereochemistry of cyclic peptides has been reported to have a great influence on microsomal stability and membrane permeability, two important factors that determine oral bioavailability. Here, we comprehensively investigated...

Changes in Electronic Properties of Polymeric One-Dimensional {[M(CN)2]−}n(M = Au, Ag) Chains Due to Neighboring Closed-Shell Zn(II) or Open-Shell Cu(II) Ions

2011 ◽  
Vol 50 (1) ◽  
pp. 231-237 ◽  
Author(s):  
François Baril-Robert ◽  
Xiaobo Li ◽  
Michael J. Katz ◽  
Andrew R. Geisheimer ◽  
Daniel B. Leznoff ◽  
...  
Keyword(s):  
Electronic Properties ◽  
Closed Shell ◽  
Open Shell ◽  
One Dimensional

Conformational Analysis of SomeC2-Symmetric Cyclic Peptides Containing Tetrahydrofuran Amino Acids†

2006 ◽  
Vol 71 (16) ◽  
pp. 6240-6243 ◽  
Author(s):  
Tushar Kanti Chakraborty ◽  
Saumya Roy ◽  
Dipankar Koley ◽  
Samit Kumar Dutta ◽  
Ajit Chand Kunwar
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Cyclic Peptides
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