IDENTIFIKASI SENYAWA KIMIA PADA BUAH SEGAR TERUNG POKAK (Solanum torvum) DENGAN METODE LCMS

The content of antioxidant compounds in pokak eggplant (Solanum torvum) had the potential as an herbal medicine and was consumed by the world population. The research objective was to study the chemical compound content of the LCMS method. Experimental design with fresh fruit extraction of pokak eggplant using 95% ethanol solvent. The parameters measured were the chemical components found in fresh fruit. The results of analysis of chemical compounds include Choline, Proline, Bis (2-ethylhexyl) phthalate, BMK ethyl glycidate, 4- Methoxycinnamic acid, chlorogenic acid, 7- Hydroxycoumarine, Trigonelline, 1- Vinylimidazole, Pipecolic acid, L- (+) - Arginine- Stearoylglycerol, Caffeine, Cetrimonium, l- Pyroglutamic acid, Erucamide, Muscone, Cucurmin, Stearamide, Betulin, Acetophenone, Ethyl oleate, SSR146977, D - (+) - Maltose, M-144, Monoolein, L-ide, Histidine, Tomatidine, Oleamide Hexadecanamide, Isoleucine, DIPEA, L- Aspartic acid, Octadecanimine, Maltol, 1-Linoleoyl glycerol, 3- Hydroxy-L- proline, Sakuranin, Leucylprolin, Diaminopimelic acid, Nervonic acid, Nootkatone, Caffeic acid, 5-Hydroxymethyl , Methyl cinnamate, Octyl decyl phthalate, 1-Aminocyclohexanecarboxylic acid, Glycerophospho-N-palmitoyl ethanolamine, 4-Methoxybenzaldehyde, Methyl palmitate, Cyclohexyl, phenyl ketone, Esculin, n-Pentyl isopentyl phthalate, - 6 -Ketoprostaglandin F1α, N, N-Dimethylsphingosin e, α-Eleostearic acid, cis-12-Octadecenoic acid methyl ester, Oleoyl ethanolamide, Citral, L-Tyrosine, XLR-11, Isovanillic acid, 1-Tetradecylamine, Isoquinoline, Calocarpin, Sedanolide, N-Acetyltyramine, Testosterone isocaproate , 2-Methyl-S-benzothiazole, 1-Aminocyclohexanecarboxylic acid, 4-Methylumbelliferyl-α-D-glucopyranoside, Dodecyltrimethylammonium, cis, cis-Muconic acid, 6-Ketoprostaglandin 4-octopamine, Lupeol, N-FeroyETl, [4- (4-Hydroxy-3-methoxyphenyl) tetrahydro-1H, 3H-furo [3,4-c] furan-1-yl] -2-methoxyphenyl hexopyranoside.

New self-assembling peptide nanotubes of large diameter using δ-amino acids

Here we show that 4-aminocyclohexanecarboxylic acid is a rigid stretcher building block for the preparation of cyclic peptides that self-assemble to form peptide nanotubes with large diameter and hydrophobic pores.

Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches

cis-2-Aminocyclohexanecarboxylic acid replacements at the edges of β-sandwiches reduce β-sheet propensities just enough to prevent aggregation but still maintain a compact structure.

Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

The preparation of novel multi-substituted 1,2,3-triazole-modified β-aminocyclohexanecarboxylic acid derivatives in a simple and efficient continuous-flow procedure is reported. The 1,3-dipolar cycloaddition reactions were performed with copper powder as a readily accessible Cu(I) source. Initially, high reaction rates were achieved under high-pressure/high-temperature conditions. Subsequently, the reaction temperature was lowered to room temperature by the joint use of both basic and acidic additives to improve the safety of the synthesis, as azides were to be handled as unstable reactants. Scale-up experiments were also performed, which led to the achievement of gram-scale production in a safe and straightforward way. The obtained 1,2,3-triazole-substituted β-aminocyclohexanecarboxylates can be regarded as interesting precursors for drugs with possible biological effects.

Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates

A regio- and stereoselective method has been developed for the synthesis of novel fluorinated 2-aminocyclohexanecarboxylic acid derivatives with the fluorine attached to position 4 of the ring. The synthesis starts from either cis- or trans-β-aminocyclohex-4-enecarboxylic acids and involves regio- and stereoselective transformation of the ring C–C double bond through iodooxazine formation and hydroxylation, followed by hydroxy–fluorine or oxo–fluorine exchange.