scholarly journals Phosphorous pentoxide-free bioactive glass exhibits dose-dependent angiogenic and osteogenic capacities which are retained in glass polymeric composite scaffolds

2021 ◽  
Author(s):  
Sonia Font Tellado ◽  
José A. Delgado ◽  
Patrina S.P. Poh ◽  
Wen Zhang ◽  
Maite García-Vallés ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polymeric Composite ◽  
Composite Scaffolds ◽  
Bioactive Glasses ◽  
Phosphorous Pentoxide ◽  
Dose Dependent

Bioactive glasses (BGs) are attractive materials for bone tissue engineering because of their bioactivity and osteoinductivity. In this study, we report the synthesis of a novel phosphorous pentoxide-free, silicate-based bioactive...

In vitro degradation and bioactivity of poly(propylene fumarate)/bioactive glass sintered microsphere scaffolds for bone tissue engineering

2016 ◽  
Vol 23 (3) ◽  
pp. 245-256 ◽  
Author(s):  
Sima Shahabi ◽  
Yashar Rezaei ◽  
Fathollah Moztarzadeh ◽  
Farhood Najafi
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
P Uptake ◽  
Surface Reactivity ◽  
Ion Concentration ◽  
Composite Scaffolds ◽  
Poly Propylene

AbstractWe developed degradable poly(propylene fumarate)/bioactive glass (PPF/BG) composite scaffolds based on a sintered microsphere technique and investigated the effects of BG content on the characteristics of these composite scaffolds. Immersion in a simulated body fluid (SBF) was used to evaluate the surface reactivity of composite scaffolds. The surface of composite scaffolds was covered with hydroxycarbonate apatite layer after 7 days of immersion. Ion concentration analyses revealed a decrease in P concentration and an increase in Si, Ca, and Sr concentrations in SBF immersed with composite scaffolds during the 3-week period. The Ca and P uptake rates decreased after 4 days of incubation. This coincided with the decrease of the Si release rate. These data lend support to the suggestion that the Si released from the BG content of scaffolds present in the polymer matrix was involved in the formation of the Ca-P layer. The evaluation of the in vitro degradation of composite microspheres revealed that the weight of scaffolds remained relatively constant during the first 3 weeks and then started to decrease slowly, losing 10.5% of their initial mass by week 12. Our results support the concept that these new bioactive, degradable composite scaffolds may be used for bone tissue engineering applications.

Mapping the elemental and crystalline phase distribution in Cu2+ doped 45S5 bioactive glass upon crystallization

CrystEngComm ◽  
2021 ◽  
Author(s):  
Qaisar Nawaz ◽  
Araceli de Pablos Martin ◽  
Lutz Berthold ◽  
Juliana Martins de Souza e Silva ◽  
Katrin Hurle ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Crystalline Phase ◽  
Phase Distribution ◽  
Metallic Ions ◽  
Bioactive Glasses ◽  
Stimulation Of

Bioactive glasses (BGs) incorporating metallic ions to impart antibacterial activity and stimulation of osteogenesis and angiogenesis are promising candidates for bone tissue engineering. Silicate BGs of the 45S5 composition (45...

Preparation and Characterization of Biomimetic Mesoporous Bioactive Glass-Silk Fibroin Composite Scaffold for Bone Tissue Engineering

2013 ◽  
Vol 796 ◽  
pp. 9-14 ◽  
Author(s):  
Cai Hong Lei ◽  
Xin Xing Feng ◽  
Ya Yang Xu ◽  
Yue Rong Li ◽  
Hai Lin Zhu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Silk Fibroin ◽  
Composite Scaffold ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Composite Scaffolds ◽  
Mesoporous Bioactive Glass

Three-dimensional (3D) mesoporous bioactive glass (MBG) scaffolds were obtained by using the demineralized bone matrix (DBM) and P123 as co-templates through a dip-coating method followed by evaporation induced self-assembly (EISA) process. 3D mesoporous bioactive glass-silk fibroin (MBG/SF) composite scaffolds were prepared by immersing MBG scaffolds into SF solutions with different concentration. Transmission electron microscopy (TEM), field mission scanning electron microscope (FESEM), fourier transform infrared spectroscopy (FT-IR) and wide angle X-ray diffraction (WA-XRD) were used to analyze the inner pore structures, pore sizes, morphologies and composition of the scaffolds. The in vitro bioactivity of the scaffolds was evaluated by soaking in simulated body fluid (SBF). The results showed that the MBG and MBG/SF composite scaffolds with the interconnected macroporous network and mesoporous walls could be obtained by this method. In addition, both the MBG scaffolds and the MBG/SF composite scaffolds have excellent apatite-forming bioactivity. Therefore, this method provides a simple way to prepare scaffolds for bone tissue engineering.

scholarly journals Hydroxyapatite Whisker Reinforced 63s Glass Scaffolds for Bone Tissue Engineering

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Cijun Shuai ◽  
Yiyuan Cao ◽  
Chengde Gao ◽  
Pei Feng ◽  
Tao Xiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Fracture Toughness ◽  
Tissue Engineering ◽  
Compressive Strength ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Selective Laser Sintering ◽  
Composite Scaffolds

Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by selective laser sintering (SLS). It was found that the optimal compressive strength and fracture toughness were achieved when 10 wt.% HANw was added. This led to 36% increase in compressive strength and 83% increase in fracture toughness, respectively, compared with pure 63s glass scaffolds. Different reinforcement mechanisms were analyzed based on the microstructure investigation. Whisker bridging and whisker pulling-out were efficient in absorbing crack propagating energy, resulting in the improvement of the mechanical properties. Moreover, bioactivity and biocompatibility of the scaffolds were evaluated in vitro. The results showed that composite scaffolds with 10 wt.% HANw exhibited good apatite-forming ability and cellular affinity.

Crosslinked poly(ε-caprolactone/D,L-lactide)/bioactive glass composite scaffolds for bone tissue engineering

2006 ◽  
Vol 77A (2) ◽  
pp. 261-268 ◽  
Author(s):  
V.V. Meretoja ◽  
A.O. Helminen ◽  
J.J. Korventausta ◽  
V. Haapa-aho ◽  
J.V. Seppälä ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glass Composite ◽  
Composite Scaffolds
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