scholarly journals Rational Design of Aqueous Conjugated Polymer Nanoparticles as Potential Theranostic Agents of Breast Cancer

2021 ◽  
Author(s):  
Panagiota Koralli ◽  
Spyridon Tsikalakis ◽  
Maria Goulielmaki ◽  
Stella Arelaki ◽  
Janina Müller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Absorption Coefficient ◽  
Conjugated Polymer ◽  
Rational Design ◽  
Polymer Nanoparticles ◽  
Quantum Yields ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents ◽  
High Absorption Coefficient ◽  
High Absorption

Conjugated polymer nanoparticles (CPNs) have emerged as a new promising class of cancer theranostic agents due to their desirable optical features, such as high absorption coefficient and photoluminescence quantum yields,...

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles

2018 ◽  
Vol 10 (13) ◽  
pp. 10634-10646 ◽  
Author(s):  
Guorui Jin ◽  
Rongyan He ◽  
Qian Liu ◽  
Yuqing Dong ◽  
Min Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Conjugated Polymer ◽  
Triple Negative ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

scholarly journals New conjugated polymer nanoparticles with high photoluminescence quantum yields for far-red and near infrared fluorescence bioimaging

2020 ◽  
Vol 4 (8) ◽  
pp. 2357-2369 ◽  
Author(s):  
Panagiota Koralli ◽  
Alkmini D. Nega ◽  
Lida Evmorfia Vagiaki ◽  
Aristea Pavlou ◽  
Michael G. Siskos ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Quantum Yields ◽  
Near Infrared Fluorescence ◽  
Conjugated Polymer Nanoparticles ◽  
Fluorescence Bioimaging

The development of new aqueous conjugated polymer nanoparticles with high photoluminescence quantum yields (PLQYs) at the far red and near infrared (NIR) spectral regions (>650 nm) as alternative polymer probes for fluorescence imaging is reported.

Bis-diketopyrrolopyrrole conjugated polymer nanoparticles as photothermic nanoagonist for specific and synergistic glioblastoma therapy

Biomaterials ◽  
2019 ◽  
Vol 216 ◽  
pp. 119252 ◽  
Author(s):  
Shengliang Li ◽  
Qingyuan Deng ◽  
Xiao Li ◽  
Yongwei Huang ◽  
Xiaozhen Li ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Theranostic Near-Infrared-Active Conjugated Polymer Nanoparticles

ACS Nano ◽  
2021 ◽  
Author(s):  
Miao Zhao ◽  
Edward Leggett ◽  
Struan Bourke ◽  
Souzana Poursanidou ◽  
Sadie Carter-Searjeant ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles

Far-red/near-infrared fluorescent conjugated polymer nanoparticles with size-dependent chirality and cell imaging applications

2015 ◽  
Vol 6 (21) ◽  
pp. 3962-3969 ◽  
Author(s):  
Chunhui Dai ◽  
Dongliang Yang ◽  
Wenjie Zhang ◽  
Biqing Bao ◽  
Yixiang Cheng ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Cell Imaging ◽  
Polymer Nanoparticles ◽  
Size Dependent ◽  
Conjugated Polymer Nanoparticles ◽  
Nanoparticle Sizes

We prepared a series of novel chiral far-red/near-infrared fluorescent CPNs with different nanoparticle sizes, which show size-dependent chirality and are successfully employed for cell imaging.

scholarly journals Conjugated Polymer Nanoparticles for Bioimaging

Materials ◽  
2017 ◽  
Vol 10 (12) ◽  
pp. 1420 ◽  
Author(s):  
Yasmine Braeken ◽  
Srujan Cheruku ◽  
Anitha Ethirajan ◽  
Wouter Maes
Keyword(s):  
Conjugated Polymer ◽  
Polymer Nanoparticles ◽  
Conjugated Polymer Nanoparticles
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