In situ phosphonium-containing Lewis base-catalyzed 1,6-cyanation reaction: facile way to α-diaryl and α-triaryl acetonitriles

2021 ◽  
Author(s):  
Jian-Ping Tan ◽  
Yuan Chen ◽  
Xiaoyu Ren ◽  
Yumeng Guo ◽  
Bing Yi ◽  
...  
Keyword(s):  
Butyl Acrylate ◽  
Lewis Base ◽  
Base Catalyst ◽  
Tert Butyl ◽  
Cyanation Reaction

Herein, we presente a phosphonium-containing catalyst generated in situ from phosphine and tert-butyl acrylate serves as an unusual Lewis base catalyst, and its successful application in promoting remote 1,6-cyanation reaction...

Synthesis of hydrosilanes via Lewis-base-catalysed reduction of alkoxy silanes with NaBH4

2019 ◽  
Vol 55 (42) ◽  
pp. 5859-5862 ◽  
Author(s):  
Keiya Aoyagi ◽  
Yu Ohmori ◽  
Koya Inomata ◽  
Kazuhiro Matsumoto ◽  
Shigeru Shimada ◽  
...  
Keyword(s):  
Lewis Base ◽  
Base Catalyst ◽  
Hexamethylphosphoric Triamide

Hydrosilanes were synthesized by reduction of alkoxysilanes with BH3 in the presence of hexamethylphosphoric triamide (HMPA) as a Lewis-base catalyst. The reaction was also achieved using an inexpensive and easy-to-handle handled hydride source NaBH4, which reacted with EtBr as a sacrificial reagent to form BH3in situ.

Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Synthesis ◽  
2019 ◽  
Vol 51 (12) ◽  
pp. 2474-2483 ◽  
Author(s):  
Peter Helmut Huy
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Functional Group ◽  
Lewis Base ◽  
Base Catalyst ◽  
Reaction Conditions ◽  
Novel Method ◽  
In Situ Formation ◽  
Type Intermediate

Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N-formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.

Hydrogen Bonding-Derived Healable Polyacrylate Elastomers via On-demand Copolymerization of n-Butyl Acrylate and tert-Butyl Acrylate

2020 ◽  
Vol 12 (45) ◽  
pp. 50812-50822
Author(s):  
Wenyan Wang ◽  
Zongxu Liu ◽  
Zijian Guo ◽  
Junliang Zhang ◽  
Chunmei Li ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Butyl Acrylate ◽  
Tert Butyl ◽  
On Demand

scholarly journals PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

2021 ◽  
pp. 174751982098753
Author(s):  
Xiaofang Wu ◽  
Lei Zhou ◽  
Fangshao Li ◽  
Jing Xiao
Keyword(s):  
Acid Chloride ◽  
Bioactive Molecules ◽  
Mechanistic Studies ◽  
One Pot ◽  
Tert Butyl ◽  
Butyl Esters

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

scholarly journals Synthesis of Poly(methacrylic acid-co-butyl acrylate) Grafted onto Functionalized Carbon Nanotube Nanocomposites for Drug Delivery

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 533 ◽  
Author(s):  
Josué A. Torres-Ávalos ◽  
Leonardo R. Cajero-Zul ◽  
Milton Vázquez-Lepe ◽  
Fernando A. López-Dellamary ◽  
Antonio Martínez-Richa ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Methacrylic Acid ◽  
Butyl Acrylate ◽  
Chemical Vapor ◽  
Vis Spectroscopy ◽  
Ir And Raman Spectroscopies ◽  
Ft Ir

Design of a smart drug delivery system is a topic of current interest. Under this perspective, polymer nanocomposites (PNs) of butyl acrylate (BA), methacrylic acid (MAA), and functionalized carbon nanotubes (CNTsf) were synthesized by in situ emulsion polymerization (IEP). Carbon nanotubes were synthesized by chemical vapor deposition (CVD) and purified with steam. Purified CNTs were analyzed by FE-SEM and HR-TEM. CNTsf contain acyl chloride groups attached to their surface. Purified and functionalized CNTs were studied by FT-IR and Raman spectroscopies. The synthesized nanocomposites were studied by XPS, 13C-NMR, and DSC. Anhydride groups link CNTsf to MAA–BA polymeric chains. The potentiality of the prepared nanocomposites, and of their pure polymer matrices to deliver hydrocortisone, was evaluated in vitro by UV–VIS spectroscopy. The relationship between the chemical structure of the synthesized nanocomposites, or their pure polymeric matrices, and their ability to release hydrocortisone was studied by FT-IR spectroscopy. The hydrocortisone release profile of some of the studied nanocomposites is driven by a change in the inter-associated to self-associated hydrogen bonds balance. The CNTsf used to prepare the studied nanocomposites act as hydrocortisone reservoirs.

Bacterial adhesion to toroidal nano-structures from poly(styrene)-block-poly(tert-butyl acrylate) diblock copolymer thin films

2010 ◽  
Vol 87 (5-8) ◽  
pp. 715-718 ◽  
Author(s):  
Shuyan Li ◽  
Andras Z. Komaromy ◽  
Dan V. Nicolau ◽  
Reinhard I. Boysen ◽  
Milton T.W. Hearn
Keyword(s):  
Thin Films ◽  
Diblock Copolymer ◽  
Butyl Acrylate ◽  
Bacterial Adhesion ◽  
Tert Butyl ◽  
Nano Structures
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