Histone deacetylase 6– HDAC6– a new regulator of glucocorticoid receptor-mediated metabolic processes

2010 ◽  
Vol 5 (S 01) ◽  
Author(s):  
R Winkler ◽  
M Clemenz ◽  
M Bloch ◽  
A Foryst-Ludwig ◽  
C Böhm ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Metabolic Processes

scholarly journals Enhancement of Stress Resilience Through Histone Deacetylase 6–Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics

2015 ◽  
Vol 77 (4) ◽  
pp. 345-355 ◽  
Author(s):  
Jeanine Jochems ◽  
Sarah L. Teegarden ◽  
Yong Chen ◽  
Janette Boulden ◽  
Collin Challis ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Stress Resilience

Inhibition of Histone Deacetylase 6 Protects Hippocampal Cells Against Mitochondria-mediated Apoptosis in a Model of Severe Oxygen-glucose Deprivation

2019 ◽  
Vol 19 (9) ◽  
pp. 673-682 ◽  
Author(s):  
Panpan Chang ◽  
Yuzi Tian ◽  
Aaron M. Williams ◽  
Umar F. Bhatti ◽  
Baoling Liu ◽  
...  
Keyword(s):  
Membrane Potential ◽  
Cytochrome C ◽  
Cell Viability ◽  
Histone Deacetylase ◽  
Caspase 3 ◽  
Cell Counting ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Histone Deacetylase 6 ◽  
Phosphorylated Akt ◽  
Ldh Release

Background: Histone deacetylase (HDAC) 6 inhibitors have demonstrated significant protective effects in traumatic injuries. However, their roles in neuroprotection and underlying mechanisms are poorly understood. This study sought to investigate the neuroprotective effects of Tubastatin A (Tub-A), an HDAC6 inhibitor, during oxygenglucose deprivation (OGD) in HT22 hippocampal cells. Methods: HT22 hippocampal cells were exposed to OGD. Cell viability and cytotoxicity were assessed by cell counting kit-8 (CCK-8) and lactate dehydrogenase (LDH) release assay. Cellular apoptosis was assessed by Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Mitochondria membrane potential was detected using JC-1 dye. Expressions of acetylated α-tubulin, α-tubulin, cytochrome c, VDAC, Bax, Bcl- 2, cleaved caspase 3, phosphorylated Akt, Akt, phosphorylated GSK3β and GSK3β were analyzed by Western blot analysis. Results: Tub-A induced acetylation of α-tubulin, demonstrating appropriate efficacy. Tub-A significantly increased cell viability and attenuated LDH release after exposure to OGD. Furthermore, Tub-A treatment blunted the increase in TUNEL-positive cells following OGD and preserved the mitochondrial membrane potential. Tub-A also attenuated the release of cytochrome c from the mitochondria into the cytoplasm and suppressed the ratio of Bax/Bcl-2 and cleaved caspase 3. This was mediated, in part, by the increased phosphorylation of Akt and GSK3β signaling pathways. Conclusion: HDAC 6 inhibition, using Tub-A, protects against OGD-induced injury in HT22 cells by modulating Akt/GSK3β signaling and inhibiting mitochondria-mediated apoptosis.

A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity

2021 ◽  
Vol 64 (3) ◽  
pp. 1362-1391 ◽  
Author(s):  
Xin-Hui Zhang ◽  
Qin-Ma ◽  
Hui-Pan Wu ◽  
Mussa Yussuf Khamis ◽  
Yi-Han Li ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Functional Diversity ◽  
Histone Deacetylase 6 ◽  
Structural Specificity

scholarly journals Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity

2017 ◽  
Vol 293 (6) ◽  
pp. 1976-1993 ◽  
Author(s):  
Jheng-Yu Wu ◽  
Shengyan Xiang ◽  
Mu Zhang ◽  
Bin Fang ◽  
He Huang ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 6 ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal
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