Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity

Jheng-Yu Wu; Shengyan Xiang; Mu Zhang; Bin Fang; He Huang; Oh Kwang Kwon; Yingming Zhao; Zhe Yang; Wenlong Bai; Gerold Bepler; Xiaohong Mary Zhang

doi:10.1074/jbc.m117.795955

Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity

Journal of Biological Chemistry ◽

10.1074/jbc.m117.795955 ◽

2017 ◽

Vol 293 (6) ◽

pp. 1976-1993 ◽

Cited By ~ 11

Author(s):

Jheng-Yu Wu ◽

Shengyan Xiang ◽

Mu Zhang ◽

Bin Fang ◽

He Huang ◽

...

Keyword(s):

Histone Deacetylase ◽

Histone Deacetylase 6 ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration

Journal of Biological Chemistry ◽

10.1074/jbc.m113.472506 ◽

2013 ◽

Vol 288 (46) ◽

pp. 33156-33170 ◽

Cited By ~ 49

Author(s):

Kendra A. Williams ◽

Mu Zhang ◽

Shengyan Xiang ◽

Chen Hu ◽

Jheng-Yu Wu ◽

...

Keyword(s):

Cell Migration ◽

Histone Deacetylase ◽

Histone Deacetylase 6 ◽

Extracellular Signal Regulated Kinase ◽

Stimulate Cell ◽

Extracellular Signal

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The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways

British Journal of Haematology ◽

10.1111/bjh.12498 ◽

2013 ◽

Vol 163 (1) ◽

pp. 72-80 ◽

Cited By ~ 15

Author(s):

Juraj Bodo ◽

Xiaoxian Zhao ◽

Arishya Sharma ◽

Brian T. Hill ◽

Craig A. Portell ◽

...

Keyword(s):

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Pi3k Inhibitor ◽

Proliferation Inhibition ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Deacetylase Inhibitor ◽

Phosphatidylinositol 3

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Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

Cell Death and Disease ◽

10.1038/cddis.2010.21 ◽

2010 ◽

Vol 1 (5) ◽

pp. e44-e44 ◽

Cited By ~ 21

Author(s):

W-W Lei ◽

K-H Zhang ◽

X-C Pan ◽

D-M Wang ◽

Y Hu ◽

...

Keyword(s):

Histone Deacetylase ◽

Extracellular Signal Regulated Kinase ◽

Histone Deacetylase 1 ◽

Extracellular Signal ◽

Opposing Effects

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Involvement of Extracellular Signal-Regulated Kinase Activation in Human Osteosarcoma Cell Resistance to the Histone Deacetylase Inhibitor FK228 [(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone]

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.108.147462 ◽

2008 ◽

Vol 328 (3) ◽

pp. 839-848 ◽

Cited By ~ 12

Author(s):

Hiroshi Matsubara ◽

Motonobu Watanabe ◽

Tsuyoshi Imai ◽

Yoshihiro Yui ◽

Yasuhiro Mizushima ◽

...

Keyword(s):

Histone Deacetylase ◽

Histone Deacetylase Inhibitor ◽

Osteosarcoma Cell ◽

Cell Resistance ◽

Kinase Activation ◽

Extracellular Signal Regulated Kinase ◽

Human Osteosarcoma ◽

Extracellular Signal ◽

Deacetylase Inhibitor ◽

Human Osteosarcoma Cell

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An experimental study in reducing blood pressure in spontaneously hypertensive rats through extracellular signal-regulated kinase inhibition

Cell Biology International ◽

10.1042/cbi034s031b ◽

2010 ◽

Vol 34 (8) ◽

pp. S31-S31

Author(s):

Li Jing ◽

Jian‑zhong Zhang ◽

Jin‑ping Sun ◽

Xin An ◽

Feng‑ying Guo ◽

...

Keyword(s):

Blood Pressure ◽

Experimental Study ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

Kinase Inhibition ◽

Spontaneously Hypertensive ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal

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Histone deacetylase 6– HDAC6– a new regulator of glucocorticoid receptor-mediated metabolic processes

Diabetologie und Stoffwechsel ◽

10.1055/s-0030-1254011 ◽

2010 ◽

Vol 5 (S 01) ◽

Author(s):

R Winkler ◽

M Clemenz ◽

M Bloch ◽

A Foryst-Ludwig ◽

C Böhm ◽

...

Keyword(s):

Glucocorticoid Receptor ◽

Histone Deacetylase ◽

Histone Deacetylase 6 ◽

Metabolic Processes

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Extracellular signal-regulated kinase mediates adrenal steroidogenesis induced by native and oxidized low-density lipoprotein

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2007-972483 ◽

2007 ◽

Vol 115 (S 1) ◽

Author(s):

S Kopprasch ◽

I Ansurudeen ◽

J Pietzsch ◽

J Graessler ◽

SR Bornstein

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Oxidized Low Density Lipoprotein ◽

Extracellular Signal Regulated Kinase ◽

Adrenal Steroidogenesis ◽

Extracellular Signal

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Faculty Opinions recommendation of Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006218.77810 ◽

2002 ◽

Author(s):

Angel Nebreda

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Premature Senescence ◽

Extracellular Signal Regulated Kinase ◽

Oncogenic Ras ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Sequential Activation

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Faculty Opinions recommendation of Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1006162.77106 ◽

2002 ◽

Author(s):

Roger Patient

Keyword(s):

Myocardial Cell ◽

Extracellular Signal Regulated Kinase ◽

Cell Hypertrophy ◽

Extracellular Signal

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Faculty Opinions recommendation of S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1165120.628022 ◽

2009 ◽

Author(s):

Yvonne Dempsie

Keyword(s):

Smooth Muscle ◽

Cell Migration ◽

Vascular Smooth Muscle ◽

Smooth Muscle Cell ◽

Bone Morphogenetic Protein 2 ◽

Extracellular Signal Regulated Kinase ◽

Morphogenetic Protein ◽

Extracellular Signal ◽

Smooth Muscle Cell Migration ◽

Intracellular Channel

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