scholarly journals Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior

2021 ◽  
Vol 118 (36) ◽  
pp. e2103642118
Author(s):  
Arndt-Lukas Klaassen ◽  
Anne Heiniger ◽  
Pilar Vaca Sánchez ◽  
Michael A. Harvey ◽  
Gregor Rainer

Daily life requires transitions between performance of well-practiced, automatized behaviors reliant upon internalized representations and behaviors requiring external focus. Such transitions involve differential activation of the default mode network (DMN), a group of brain areas associated with inward focus. We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts task switching between internally to externally guided lever-pressing behavior in the rat. Excitation of the VP dramatically compromised acquisition of an auditory discrimination task, trapping animals in a DMN state of automatized internally focused behavior and impairing their ability to direct attention to external sensory stimuli. VP inhibition, on the other hand, facilitated task acquisition, expediting escape from the DMN brain state, thereby allowing rats to incorporate the contingency changes associated with the auditory stimuli. We suggest that VP, instant by instant, regulates the DMN and plays a deterministic role in transitions between internally and externally guided behaviors.

2018 ◽  
Vol 115 (6) ◽  
pp. 1352-1357 ◽  
Author(s):  
Jayakrishnan Nair ◽  
Arndt-Lukas Klaassen ◽  
Jozsef Arato ◽  
Alexei L. Vyssotski ◽  
Michael Harvey ◽  
...  

The default mode network (DMN) is a collection of cortical brain regions that is active during states of rest or quiet wakefulness in humans and other mammalian species. A pertinent characteristic of the DMN is a suppression of local field potential gamma activity during cognitive task performance as well as during engagement with external sensory stimuli. Conversely, gamma activity is elevated in the DMN during rest. Here, we document that the rat basal forebrain (BF) exhibits the same pattern of responses, namely pronounced gamma oscillations during quiet wakefulness in the home cage and suppression of this activity during active exploration of an unfamiliar environment. We show that gamma oscillations are localized to the BF and that gamma-band activity in the BF has a directional influence on a hub of the rat DMN, the anterior cingulate cortex, during DMN-dominated brain states. The BF is well known as an ascending, activating, neuromodulatory system involved in wake–sleep regulation, memory formation, and regulation of sensory information processing. Our findings suggest a hitherto undocumented role of the BF as a subcortical node of the DMN, which we speculate may be important for switching between internally and externally directed brain states. We discuss potential BF projection circuits that could underlie its role in DMN regulation and highlight that certain BF nuclei may provide potential target regions for up- or down-regulation of DMN activity that might prove useful for treatment of DMN dysfunction in conditions such as epilepsy or major depressive disorder.


2013 ◽  
Vol 109 (5) ◽  
pp. 1250-1258 ◽  
Author(s):  
Oliver Hinds ◽  
Todd W. Thompson ◽  
Satrajit Ghosh ◽  
Julie J. Yoo ◽  
Susan Whitfield-Gabrieli ◽  
...  

We used real-time functional magnetic resonance imaging (fMRI) to determine which regions of the human brain have a role in vigilance as measured by reaction time (RT) to variably timed stimuli. We first identified brain regions where activation before stimulus presentation predicted RT. Slower RT was preceded by greater activation in the default-mode network, including lateral parietal, precuneus, and medial prefrontal cortices; faster RT was preceded by greater activation in the supplementary motor area (SMA). We examined the roles of these brain regions in vigilance by triggering trials based on brain states defined by blood oxygenation level-dependent activation measured using real-time fMRI. When activation of relevant neural systems indicated either a good brain state (increased activation of SMA) or a bad brain state (increased activation of lateral parietal cortex and precuneus) for performance, a target was presented and RT was measured. RTs on trials triggered by a good brain state were significantly faster than RTs on trials triggered by a bad brain state. Thus human performance was controlled by monitoring brain states that indicated high or low vigilance. These findings identify neural systems that have a role in vigilance and provide direct evidence that the default-mode network has a role in human performance. The ability to control and enhance human behavior based on brain state may have broad implications.


2012 ◽  
Author(s):  
Rosemarie Kluetsch ◽  
Tomas Ros ◽  
Jean Theberge ◽  
Paul Frewen ◽  
Christian Schmahl ◽  
...  

2020 ◽  
Vol 34 (7) ◽  
pp. 811-823
Author(s):  
Evgeniya Yu. Privodnova ◽  
Helena R. Slobodskaya ◽  
Andrey V. Bocharov ◽  
Alexander E. Saprigyn ◽  
Gennady G. Knyazev

2014 ◽  
Vol 45 (01) ◽  
Author(s):  
G Mingoia ◽  
K Langbein ◽  
M Dietzek ◽  
G Wagner ◽  
S Smesny ◽  
...  

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