The uncertainty of economic policy, a specific form of uncertainty, can affect both economic growth, and the effectiveness of the macroeconomic regulation and control policy. Existing studies have analyzed the impacts of economic policy uncertainty on investment, consumption, trade, and total factor survival, but there is no analysis of the effectiveness of macroeconomic regulation and control policies on output and technological progress in a deterministic environment. Output growth and technological progress show the performance of economic growth in gross and efficiency, respectively, which is the external performance and internal driving force of economic growth. To achieve long-term sustainable economic development, it is necessary to consider both the aggregate problem and technological progress. In this context, this paper attempts to explore the effectiveness of China’s macroeconomic regulation and control policy on output growth and technological progress under the economic policy uncertainty. Specifically, this paper first analyzes the effectiveness of macroeconomic regulation and control policy on China’s output growth and technological progress in an uncertain environment, and then makes an empirical study by constructing a time-varying parameter vector autoregression model (TVP-VAR). Furthermore, the simulation test of the relevant results is carried out using the counter-fact analysis method. The empirical results show that: (1) under the uncertainty environment, the direction of the effect of price monetary policy on output has not changed, the effect of interest rate increase on output growth is negative, and the impact is stronger in the short term than in the medium and long term; the effect of rising interest rates on technological progress is positive, and the effect intensity is also significant in the short term, but weak in the medium and long term, the effect of price monetary policy on output is stronger under moderate uncertainty. (2) Credit growth can promote output growth, and the regulation effect of credit growth on output growth is mainly reflected in the short term under the TVP-VAR model, the effect of credit growth on technological progress is not significant. Further research using counterfactual analysis shows that the uncertain environment will reduce the effect of credit policy on output growth, but the effect is not significant.